Evidence map›Paper›PMID 34589640›Full record

ArticleGeoHealth2021

Global Cancer Risk From Unregulated Polycyclic Aromatic Hydrocarbons.

Jamie M Kelly, Peter D Ivatt, Mathew J Evans, Jesse H Kroll, Amy I H Hrdina, Ishwar N Kohale, Forest M White, Bevin P Engelward, Noelle E Selin

Open access · goldAbstract read
In one paragraph

Article in GeoHealth, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
3.9field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 49 citations in OpenAlex.

  1. Article
  2. Quantifying the wildfire contribution to PAH concentrations and health effects.Environmental research letters : ERL [Web site] · 2026
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  3. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 4 institutions in 2 countries.

Jamie M KellyInstitute for Data, Systems, and Society Massachusetts Institute of Technology Cambridge MA USA.ORCID https://orcid.org/0000-0002-6637-5222
Peter D IvattWolfson Atmospheric Chemistry Laboratories Department of Chemistry University of York York UK.
Mathew J EvansWolfson Atmospheric Chemistry Laboratories Department of Chemistry University of York York UK.ORCID https://orcid.org/0000-0003-4775-032X
Jesse H KrollDepartment of Civil and Environmental Engineering Massachusetts Institute of Technology Cambridge MA USA.ORCID https://orcid.org/0000-0002-6275-521X
Amy I H HrdinaDepartment of Civil and Environmental Engineering Massachusetts Institute of Technology Cambridge MA USA.ORCID https://orcid.org/0000-0002-2126-8060
Ishwar N KohaleDepartment of Biological Engineering Massachusetts Institute of Technology Cambridge MA USA.ORCID https://orcid.org/0000-0001-8225-1740
Forest M WhiteDepartment of Biological Engineering Massachusetts Institute of Technology Cambridge MA USA.ORCID https://orcid.org/0000-0002-1545-1651
Bevin P EngelwardCenter for Precision Cancer Medicine Massachusetts Institute of Technology Cambridge MA USA.ORCID https://orcid.org/0000-0003-4322-3573
Noelle E SelinInstitute for Data, Systems, and Society Massachusetts Institute of Technology Cambridge MA USA.ORCID https://orcid.org/0000-0002-6396-5622
Massachusetts Institute of Technology · USPrecision for Medicine (United States) · USNational Centre for Atmospheric Science · GBUniversity of York · GB

Funding

The MIT Superfund Research Program: A Systems Approach for the Protection of Human Health from Hazardous ChemicalsP42ES027707 · NIEHS · MASSACHUSETTS INSTITUTE OF TECHNOLOGY · PI Desiree Plata · 2017 to 2026
$22.2M
NIEHS NIH HHS P42 ES027707
6 · The paper itself

Abstract

In assessments of cancer risk from atmospheric polycyclic aromatic hydrocarbons (PAHs), scientists and regulators rarely consider the complex mixture of emitted compounds and degradation products, and they often represent the entire mixture using a single emitted compound-benzo[a]pyrene. Here, we show that benzo[a]pyrene is a poor indicator of PAH risk distribution and management: nearly 90% of cancer risk worldwide results from other PAHs, including unregulated degradation products of emitted PAHs. We develop and apply a global-scale atmospheric model and conduct health impact analyses to estimate human cancer risk from 16 PAHs and several of their N-PAH degradation products. We find that benzo[a]pyrene is a minor contributor to the total cancer risks of PAHs (11%); the remaining risk comes from other directly emitted PAHs (72%) and N-PAHs (17%). We show that assessment and policy-making that relies solely on benzo[a]pyrene exposure provides misleading estimates of risk distribution, the importance of chemical processes, and the prospects for risk mitigation. We conclude that researchers and decision-makers should consider additional PAHs as well as degradation products.

Indexed as

air pollutionbenzo[a]pyrenecancerhuman healthmixturespolycyclic aromatic hydrocarbons

Identifiers

PMID34589640
PMCPMC8460132
OpenAlexW3137892410

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.