Evidence map›Paper›PMID 34589596›Full record

ArticleBioengineering & translational medicine2021

An engineered probiotic secreting Sj16 ameliorates colitis via Ruminococcaceae/butyrate/retinoic acid axis.

Lifu Wang, Yao Liao, Ruibing Yang, Zifeng Zhu, Lichao Zhang, Zhongdao Wu, Xi Sun

Open access · goldAbstract read
In one paragraph

Article in Bioengineering & translational medicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 56 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
56citing papers in PubMed, 2 pooled it
6.1field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

56 citing papers in PubMed, 2 syntheses or guidelines pooled it, 100 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Article
  4. Review
  5. Review
  6. Article
  7. Review
  8. Article
  9. Review
  10. Current and emerging approaches to manage chronic inflammatory gut disorders.Frontiers in cellular and infection microbiology · 2026
    Review
  11. EngineeredFrontiers in immunology · 2026
    Article
  12. Autism-Associated Gut Microbiota-DerivedPathogens (Basel, Switzerland) · 2025
    Article
  13. Review
  14. Article
  15. Review
  16. Article
  17. Review
  18. Review
  19. Administration of a Next-Generation ProbioticThe Canadian journal of infectious diseases & medical microbiology = Journal canadien des maladies infectieuses et de la microbiologie medicale · 2025
    Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Lifu WangDepartment of Parasitology, Zhongshan School of Medicine Sun Yat-sen University Guangzhou China.
Yao LiaoDepartment of Parasitology, Zhongshan School of Medicine Sun Yat-sen University Guangzhou China.
Ruibing YangDepartment of Parasitology, Zhongshan School of Medicine Sun Yat-sen University Guangzhou China.
Zifeng ZhuDepartment of Parasitology, Zhongshan School of Medicine Sun Yat-sen University Guangzhou China.
Lichao ZhangDepartment of Parasitology, Zhongshan School of Medicine Sun Yat-sen University Guangzhou China.
Zhongdao WuDepartment of Parasitology, Zhongshan School of Medicine Sun Yat-sen University Guangzhou China.
Xi SunDepartment of Parasitology, Zhongshan School of Medicine Sun Yat-sen University Guangzhou China.ORCID https://orcid.org/0000-0003-2213-3763
Sun Yat-sen University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Most inflammatory bowel disease (IBD) patients are unable to maintain a lifelong remission. Developing a novel therapeutic strategy is urgently needed. In this study, we adopt a new strategy to attenuate colitis using the

Indexed as

colitisengineered probioticRuminococcaceae/butyrate/retinoic acid axisSj16Treg/Th17 balance

Identifiers

PMID34589596
PMCPMC8459592
OpenAlexW3139857758

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.