Evidence map›Paper›PMID 34589592›Full record

ArticleBioengineering & translational medicine2021

Doxorubicin-loaded nanoparticle coated with endothelial cells-derived exosomes for immunogenic chemotherapy of glioblastoma.

Chao Zhang, Jian Song, Lei Lou, Xuejiao Qi, Lei Zhao, Bo Fan, Guozhu Sun, Zhongqiang Lv, Zhenzeng Fan, Baohua Jiao and 1 more

Erratum issuedOpen access · goldAbstract read
In one paragraph

Article in Bioengineering & translational medicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 49 papers.

0numbers the graph read from it
0cells of the map it votes in
49citing papers in PubMed
3.7field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

49 citing papers in PubMed, 98 citations in OpenAlex.

  1. Review
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  6. Article
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  10. Nano-Based Technology in Glioblastoma.Molecules (Basel, Switzerland) · 2025
    Review
  11. Article
  12. Article
  13. Review
  14. Current Understanding of the Exosomes and Their Associated Biomolecules in the Glioblastoma Biology, Clinical Treatment, and Diagnosis.Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology · 2025
    Review
  15. Review
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

11 authors at 1 institution in 1 country.

Chao ZhangDepartment of Neurosurgery, the Second Hospital of Hebei Medical University Shijiazhuang Hebei China.
Jian SongDepartment of Neurosurgery, the Second Hospital of Hebei Medical University Shijiazhuang Hebei China.
Lei LouDepartment of Neurosurgery, the Second Hospital of Hebei Medical University Shijiazhuang Hebei China.
Xuejiao QiDepartment of Neurosurgery, the Second Hospital of Hebei Medical University Shijiazhuang Hebei China.
Lei ZhaoDepartment of Neurosurgery, the Second Hospital of Hebei Medical University Shijiazhuang Hebei China.
Bo FanDepartment of Neurosurgery, the Second Hospital of Hebei Medical University Shijiazhuang Hebei China.
Guozhu SunDepartment of Neurosurgery, the Second Hospital of Hebei Medical University Shijiazhuang Hebei China.
Zhongqiang LvDepartment of Neurosurgery, the Second Hospital of Hebei Medical University Shijiazhuang Hebei China.
Zhenzeng FanDepartment of Neurosurgery, the Second Hospital of Hebei Medical University Shijiazhuang Hebei China.
Baohua JiaoDepartment of Neurosurgery, the Second Hospital of Hebei Medical University Shijiazhuang Hebei China.
Jiankai YangDepartment of Neurosurgery, the Second Hospital of Hebei Medical University Shijiazhuang Hebei China.ORCID https://orcid.org/0000-0001-9654-0260
Hebei Medical University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Treatments of glioblastoma (GBM) have not been very effective, largely due to the inefficiency of drugs in penetrating the blood brain barrier (BBB). In this study, we investigated the potential of exosome-coated doxorubicin (DOX)-loaded nanoparticles (ENP

Indexed as

blood brain barrierdoxorubicinexosome‐coated doxorubicin‐loaded nanoparticleglioblastomaimmunogenic cell death

Identifiers

PMID34589592
PMCPMC8459598
OpenAlexW3107184916

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.