Evidence map›Paper›PMID 34589469›Full record

ArticleFrontiers in bioengineering and biotechnology2021

The Synergistic Effect of Nicotine and

Yao Hu, Wen Zhou, Chengguang Zhu, Yujie Zhou, Qiang Guo, Xiaoyu Huang, Bina Yang, Biao Ren, Lei Cheng

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in bioengineering and biotechnology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.8field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 5 citations in OpenAlex.

  1. Osteomyelitis.Nature reviews. Disease primers · 2026
    Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Yao HuState Key Laboratory of Oral Diseases and West China School of Stomatology and National Clinical Research Center for Oral Diseases, Sichuan University, Chengdu, China.
Wen ZhouState Key Laboratory of Oral Diseases and West China School of Stomatology and National Clinical Research Center for Oral Diseases, Sichuan University, Chengdu, China.
Chengguang ZhuState Key Laboratory of Oral Diseases and West China School of Stomatology and National Clinical Research Center for Oral Diseases, Sichuan University, Chengdu, China.
Yujie ZhouState Key Laboratory of Oral Diseases and West China School of Stomatology and National Clinical Research Center for Oral Diseases, Sichuan University, Chengdu, China.
Qiang GuoState Key Laboratory of Oral Diseases and West China School of Stomatology and National Clinical Research Center for Oral Diseases, Sichuan University, Chengdu, China.
Xiaoyu HuangState Key Laboratory of Oral Diseases and West China School of Stomatology and National Clinical Research Center for Oral Diseases, Sichuan University, Chengdu, China.
Bina YangState Key Laboratory of Oral Diseases and West China School of Stomatology and National Clinical Research Center for Oral Diseases, Sichuan University, Chengdu, China.
Biao RenState Key Laboratory of Oral Diseases and West China School of Stomatology and National Clinical Research Center for Oral Diseases, Sichuan University, Chengdu, China.
Lei ChengState Key Laboratory of Oral Diseases and West China School of Stomatology and National Clinical Research Center for Oral Diseases, Sichuan University, Chengdu, China.
Sichuan University · CNState Key Laboratory of Oral Diseases

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Smoking is considered a key risk factor for implant survival; however, how it interacts with the pathogens in peri-implant infections is not clear. Here, we identified that nicotine, the key component of cigarette smoking, can interact with

Indexed as

nicotineperi-implant infectionRANKLStaphylococcus aureussynergistic effect

Identifiers

PMID34589469
PMCPMC8473630
OpenAlexW3201132456

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.