Evidence map›Paper›PMID 34589414›Full record

ArticleMolecular genetics and metabolism reports2020

Successful recovery from severe hypertension in a patient with Leigh syndrome.

Yuto Arai, Kiyotaka Kosugiyama, Takuya Tamura, Sasagu Matsumoto, Akira Sudo, Hideaki Shiraishi, Cammack Ivor, Akira Ohtake, Kiyoshi Nagumo

Open access · goldAbstract readCase Reports
PubMed Full text at PMC Publisher
In one paragraph

Article in Molecular genetics and metabolism reports, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.2field-weighted citation impact, top 49% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 3 citations in OpenAlex.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 4 institutions in 1 country.

Yuto AraiDepartment of Pediatrics, Teine-Keijinkai Hospital, Sapporo, Japan.
Kiyotaka KosugiyamaDepartment of Pediatrics, Hokkaido University School of Medicine, Sapporo, Japan.
Takuya TamuraDepartment of Pediatrics, Teine-Keijinkai Hospital, Sapporo, Japan.
Sasagu MatsumotoDepartment of Pediatrics, Teine-Keijinkai Hospital, Sapporo, Japan.
Akira SudoSocial Welfare Corporation Nire-no-kai Children's Clinic, Sapporo, Japan.
Hideaki ShiraishiDepartment of Pediatrics, Hokkaido University School of Medicine, Sapporo, Japan.
Cammack IvorDepartment of Clinical Residency Training, Teine-Keijinkai Hospital, Sapporo, Japan.
Akira OhtakeCenter for Intractable Diseases, Saitama Medical University Hospital, Saitama, Japan.
Kiyoshi NagumoDepartment of Pediatrics, Teine-Keijinkai Hospital, Sapporo, Japan.
Teine Keijinkai Hospital · JPHokkaido University · JPSaitama Medical University Hospital · JPSocial welfare corporation Hokkaido society Agency Obihiro · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Hypertension is a rare complication of Leigh Syndrome (LS), but prognosis of patients with hypertension is poor and its presence is indicative of the terminal stage of the disease. Herein, we report a four-year-old girl case diagnosed with LS at 15 months of age who subsequently developed severe hypertension and respiratory failure. Physical examination and laboratory findings did not indicate a secondary cause of hypertension. Her respiratory failure was treated with non-invasive ventilation and hypertension controlled with enalapril, furosemide and spironolactone. To our knowledge, this is the first case of a patient with LS recovering from severe hypertension.

Indexed as

HypertensionLeigh syndromeMedulla oblongataNucleus tractus solitariiRespiratory failure

Identifiers

PMID34589414
PMCPMC8461110
OpenAlexW3110127460

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.