Evidence map›Paper›PMID 34589396›Full record

ReviewActa pharmaceutica Sinica. B2021

Gasdermin D in pyroptosis.

Brandon E Burdette, Ashley N Esparza, Hua Zhu, Shanzhi Wang

Open access · diamondAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Acta pharmaceutica Sinica. B, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 390 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
390citing papers in PubMed, 1 pooled it
37.2field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

390 citing papers in PubMed, 1 synthesis or guideline pooled it, 650 citations in OpenAlex.

  1. Pooled it
  2. Review
  3. Review
  4. Article
  5. Article
  6. Review
  7. Review
  8. Role of pyroptosis in melanoma: Molecular mechanisms and therapeutic potentials.Apoptosis : an international journal on programmed cell death · 2026
    Review
  9. Article
  10. Review
  11. Regulated cell death-induced coagulation dysfunction in sepsis.Journal of thrombosis and thrombolysis · 2026
    Review
  12. Article
  13. Review
  14. How to recognize if a cell dies from pyroptosis?Molecular biology reports · 2026
    Review
  15. Review
  16. Review
  17. Article
  18. Article
  19. Article
  20. Article

330 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

Brandon E BurdetteBiology Department, University of Arkansas at Little Rock, Little Rock, AR 72204, USA.
Ashley N EsparzaBiology Department, University of Arkansas at Little Rock, Little Rock, AR 72204, USA.
Hua ZhuDepartment of Surgery, the Ohio State University Wexner Medical Center, Columbus, OH 43210, USA.
Shanzhi WangBiology Department, University of Arkansas at Little Rock, Little Rock, AR 72204, USA.
University of Arkansas at Little Rock · USThe Ohio State University Wexner Medical Center · US

Funding

Preservation of Limbal Stem Cell Function in Corneal InjuryR01EY030621 · NEI · OHIO STATE UNIVERSITY · PI CHANDLER, HEATHER, ZHU, HUA · 2019 to 2022
$1.6M
Inhibiting Cell Death for Protecting Cardiac InjuryR01HL153876 · NHLBI · OHIO STATE UNIVERSITY · PI ZHU, HUA · 2020 to 2023
$1.6M
NEI NIH HHS R01 EY030621NHLBI NIH HHS R01 HL153876
6 · The paper itself

Abstract

Pyroptosis is the process of inflammatory cell death. The primary function of pyroptosis is to induce strong inflammatory responses that defend the host against microbe infection. Excessive pyroptosis, however, leads to several inflammatory diseases, including sepsis and autoimmune disorders. Pyroptosis can be canonical or noncanonical. Upon microbe infection, the canonical pathway responds to pathogen-associated molecular patterns (PAMPs) and damage-associated molecular patterns (DAMPs), while the noncanonical pathway responds to intracellular lipopolysaccharides (LPS) of Gram-negative bacteria. The last step of pyroptosis requires the cleavage of gasdermin D (GsdmD) at D275 (numbering after human GSDMD) into N- and C-termini by caspase 1 in the canonical pathway and caspase 4/5/11 (caspase 4/5 in humans, caspase 11 in mice) in the noncanonical pathway. Upon cleavage, the N-terminus of GsdmD (GsdmD-N) forms a transmembrane pore that releases cytokines such as IL-1

Indexed as

7DG, 7-desacetoxy-6,7-dehydrogeduninAc-FLTD-CMK, acetyl-FLTD-chloromethylketoneADRA2B, α-2B adrenergic receptorAIM, absent in melanomaASC, associated speck-like proteinBMDM, bone marrow-derived macrophagescAMP, cyclic adenosine monophosphateCARD, caspase activationCaspaseCD, Crohn’s diseasecGAS, cyclic GMP–AMP synthaseCTM, Chinese traditional medicineCTSG, cathepsin GDamage-associated molecular patterns (DAMPs)DAMP, damage-associated molecular patternDFNA5, deafness autosomal dominant 5DFNB59, deafness autosomal recessive type 59DKD, diabetic kidney diseaseDMF, dimethyl fumarateELANE, neutrophil expressed elastaseESCRT, endosomal sorting complexes required for transportFADD, FAS-associated death domainFDA, U.S. Food and Drug AdministrationFIIND, function to find domainFMF, familial Mediterranean feverGasderminGI, gastrointestinalGPX, glutathione peroxidaseGsdmA/B/C/D/E, gasdermin A/B/C/D/EHAMP, homeostasis altering molecular patternHIN, hematopoietic expression, interferon-inducible nature, and nuclear localizationHIV, human immunodeficiency virusHMGB1, high mobility group protein B1IBD, inflammatory bowel diseaseIFN, interferonInflammasomeInflammationITPR1, inositol 1,4,5-trisphosphate receptor type 1LPS, lipopolysaccharideLRR, leucine-rich repeatMAP3K7, mitogen-activated protein kinase kinase kinase 7MCC950, N-[[(1,2,3,5,6,7-hexahydro-s-indacen-4-yl)amino]carbonyl]-4-(1-hydroxy-1-methylethyl)-2-furansulfonamidemtDNA, mitochondrial DNANAIP, NLR family apoptosis inhibitory proteinNBD, nucleotide-binding domainNEK7, NIMA-related kinase 7NET, neutrophil extracellular trapNIK, NF-κB inducing kinaseNLR, NOD-like receptorNLRP, NLR family pyrin domain containingNSAID, non-steroidal anti-inflammatory drugNSCLC, non-small cell lung cancerNSP, neutrophil specific serine proteasePAMP, pathogen-associated molecular patternPathogen-associated molecular patterns (PAMPs)PKA, protein kinase APKN1/2, protein kinase1/2PKR, protein kinase-RPRR, pattern recognition receptorsPYD, pyrin domainPyroptosisROS, reactive oxygen speciesSepsisSTING, stimulator of interferon genesTLR, Toll-like receptorUC, ulcerative colitis

Identifiers

PMID34589396
PMCPMC8463274
OpenAlexW3158874774

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.