Evidence map›Paper›PMID 34589274›Full record

ArticleMolecular therapy. Nucleic acids2021

MultiEditR: The first tool for the detection and quantification of RNA editing from Sanger sequencing demonstrates comparable fidelity to RNA-seq.

Mitchell G Kluesner, Rafail Nikolaos Tasakis, Taga Lerner, Annette Arnold, Sandra Wüst, Marco Binder, Beau R Webber, Branden S Moriarity, Riccardo Pecori

Abstract read
In one paragraph

Article in Molecular therapy. Nucleic acids, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.

0numbers the graph read from it
0cells of the map it votes in
22citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

22 citing papers in PubMed.

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  15. Article
  16. The role of ADAR1 through and beyond its editing activity in cancer.Cell communication and signaling : CCS · 2024
    Review
  17. Article
  18. Article
  19. CELLULAR RNA INTERACTS WITH MAVS TO PROMOTE ANTIVIRAL SIGNALING.bioRxiv : the preprint server for biology · 2023
    Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Mitchell G KluesnerDepartment of Pediatrics, University of Minnesota, Minneapolis, MN 55455, USA.
Rafail Nikolaos TasakisDivision of Immune Diversity, Program in Cancer Immunology, German Cancer Research Centre (DKFZ), 69120 Heidelberg, Germany.
Taga LernerDivision of Immune Diversity, Program in Cancer Immunology, German Cancer Research Centre (DKFZ), 69120 Heidelberg, Germany.
Annette ArnoldDivision of Immune Diversity, Program in Cancer Immunology, German Cancer Research Centre (DKFZ), 69120 Heidelberg, Germany.
Sandra WüstResearch Group "Dynamics of Early Viral Infection and the Innate Antiviral Response," Division Virus Associated Carcinogenesis (F170), German Cancer Research Centre (DKFZ), 69120 Heidelberg, Germany.
Marco BinderResearch Group "Dynamics of Early Viral Infection and the Innate Antiviral Response," Division Virus Associated Carcinogenesis (F170), German Cancer Research Centre (DKFZ), 69120 Heidelberg, Germany.
Beau R WebberDepartment of Pediatrics, University of Minnesota, Minneapolis, MN 55455, USA.
Branden S MoriarityDepartment of Pediatrics, University of Minnesota, Minneapolis, MN 55455, USA.
Riccardo PecoriDivision of Immune Diversity, Program in Cancer Immunology, German Cancer Research Centre (DKFZ), 69120 Heidelberg, Germany.

Funding

University of Washington Medical Scientist Training Program: MD/PhDT32GM007266 · NIGMS · UNIVERSITY OF WASHINGTON · PI HORWITZ, MARSHALL S. · 1985 to 2023
$30.4M
NIGMS NIH HHS T32 GM007266
6 · The paper itself

Abstract

We present MultiEditR (Multiple Edit Deconvolution by Inference of Traces in R), the first algorithm specifically designed to detect and quantify RNA editing from Sanger sequencing (z.umn.edu/multieditr). Although RNA editing is routinely evaluated by measuring the heights of peaks from Sanger

Indexed as

ADARAPOBECdeaminasesDNA base editingEpitranscriptomicsMultiEditR Editing IndexRNA editing detectionRNA editing quantificationRNA modificationRShiny

Identifiers

PMID34589274
PMCPMC8463291

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.