Evidence map›Paper›PMID 34589153›Full record

ArticleOncology letters2021

Reduced tissue and serum resistin expression as a clinical marker for esophageal squamous cell carcinoma.

Amos C Hung, Yen-Yun Wang, Kun-Tsung Lee, Hung-Hsing Chiang, Yuk-Kwan Chen, Je-Kang Du, Chun-Ming Chen, Michael Yuanchien Chen, Kwei-Jing Chen, Stephen Chu-Sung Hu and 1 more

Open access · diamondAbstract read
In one paragraph

Article in Oncology letters, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.6field-weighted citation impact, top 31% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 5 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 1 institution in 1 country.

Amos C HungTranslational Research Center, Kaohsiung Medical University Hospital, Kaohsiung 807, Taiwan, R.O.C.
Yen-Yun WangTranslational Research Center, Kaohsiung Medical University Hospital, Kaohsiung 807, Taiwan, R.O.C.
Kun-Tsung LeeDepartment of Oral Hygiene, Kaohsiung Medical University, Kaohsiung 807, Taiwan, R.O.C.
Hung-Hsing ChiangDepartment of Surgery, Kaohsiung Medical University Hospital, Kaohsiung 807, Taiwan, R.O.C.
Yuk-Kwan ChenSchool of Dentistry, Kaohsiung Medical University, Kaohsiung 807, Taiwan, R.O.C.
Je-Kang DuSchool of Dentistry, Kaohsiung Medical University, Kaohsiung 807, Taiwan, R.O.C.
Chun-Ming ChenSchool of Dentistry, Kaohsiung Medical University, Kaohsiung 807, Taiwan, R.O.C.
Michael Yuanchien ChenDepartment of Dentistry, China Medical University Hospital, Taichung 406, Taiwan, R.O.C.
Kwei-Jing ChenDepartment of Dentistry, China Medical University Hospital, Taichung 406, Taiwan, R.O.C.
Stephen Chu-Sung HuDepartment of Dermatology, College of Medicine, Kaohsiung Medical University, Kaohsiung 807, Taiwan, R.O.C.
Shyng-Shiou F YuanTranslational Research Center, Kaohsiung Medical University Hospital, Kaohsiung 807, Taiwan, R.O.C.
Kaohsiung Medical University · TW

Funding

CENTROSOME DYSFUNCTION IN POLYCYSTIC KIDNEY DISEASER01DK108005 · NIDDK · WASHINGTON UNIVERSITY · PI MAHJOUB, MOHAMED REZA · 2016 to 2020
$1.7M
NIDDK NIH HHS R01 DK108005
6 · The paper itself

Abstract

Esophageal cancer is one of the most common malignancies and leading cause of cancer-associated mortality worldwide. However, the molecular mechanisms underlying esophageal cancer progression and the development of clinical tools for effective diagnosis remain unclear. Resistin, which was originally identified as an adipose tissue-secretory factor, has been associated with obesity-related diseases, including certain types of cancer. Thus, the present study aimed to investigate the expression levels of resistin in tissue and serum specimens from patients with esophageal squamous cell carcinoma (ESCC) to determine the potential biological effects of resistin on ESCC cells. The results demonstrated that both tissue and serum resistin levels were significantly lower in patients with ESCC compared with healthy controls. In addition, resistin expression was positively associated with the body mass index of patients with ESCC.

Indexed as

adenylyl cyclase-associated protein 1adipocytokinebody mass indexesophageal cancerresistintoll-like receptor 4

Identifiers

PMID34589153
PMCPMC8442229
OpenAlexW3199195082

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.