ArticleInternational journal of endocrinology2021
Association between Serum Testosterone Levels and Body Composition among Men 20-59 Years of Age.
Article in International journal of endocrinology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
What it found
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The trial behind it
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Who cites it
14 citing papers in PubMed.
- Effects of testosterone and vitamin D on fall risk in pre-frail hypogonadal men: a factorial design RCT.The journal of nutrition, health & aging · 2024Trial
- The Potential Therapeutic Effects of Testosterone on Sarcopenia: A Thorough Systematic Review.Cureus · 2026Review
- Androgen levels of premenopausal females are not observably associated with body composition and physical performance, but may interact with hormonal contraceptive use.European journal of applied physiology · 2026Article
- Bioavailable testosterone and androgen receptor activation, but not total testosterone, are associated with muscle mass and strength in females.The Journal of physiology · 2025Article
- Associated factors and gender differences of falls in older adults with hypertension: a national cross-sectional survey.Frontiers in public health · 2025Article
- The Role of Bone-Derived Osteocalcin in Testicular Steroidogenesis: Contributing Factor to Male Fertility.Diseases (Basel, Switzerland) · 2024Review
- Musculoskeletal and body composition response to high-dose testosterone with finasteride after chronic incomplete spinal cord injury-a randomized, double-blind, and placebo-controlled pilot study.Frontiers in neurology · 2024Article
- The relationship between serum free testosterone level and body composition in geriatric and non-geriatric male hemodialysis patients.Journal of nephrology · 2023Article
- Roles of sex hormones in mediating the causal effect of vitamin D on osteoporosis: A two-step Mendelian randomization study.Frontiers in endocrinology · 2023Article
- Relationship between Testosterone and Sarcopenia in Older-Adult Men: A Narrative Review.Journal of clinical medicine · 2022Review
- Protection against Osteoarthritis Symptoms by Aerobic Exercise with a High-Protein Diet by Reducing Inflammation in a Testosterone-Deficient Animal Model.Life (Basel, Switzerland) · 2022Article
- Higher serum apolipoprotein B level will reduce the bone mineral density and increase the risk of osteopenia or osteoporosis in adults.Frontiers in cell and developmental biology · 2022Article
- Association between Serum Total Testosterone Level and Bone Mineral Density in Middle-Aged Postmenopausal Women.International journal of endocrinology · 2022Article
- Quercetin Attenuates Osteoporosis in Orchiectomy Mice by Regulating Glucose and Lipid MetabolismFrontiers in endocrinology · 2022Article
Corrections and comments
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionSex hormones play an important role in the development and maintenance of bone and muscle mass. However, studies regarding serum testosterone levels, osteoporosis, and sarcopenia in men are relatively sparse and have led to contradictory conclusions. Therefore, this study aimed to investigate the association between serum testosterone levels and body composition, including bone mineral density (BMD), appendicular lean mass index (ALMI), and appendicular fat mass index (AFMI), among men 20-59 years of age through a cross-sectional analysis of the National Health and Nutrition Examination Survey. MATERIALS AND
methodsOur analysis was based on the data for 3,875 men, 20-59 years of age. Weighted multiple regression analyses were used to estimate the independent association between serum testosterone levels and body composition. Weighted generalized additive models and smooth curve fittings were used to characterize the nonlinear associations between them.
resultsThe association between the serum testosterone level and lumbar BMD was positive in each multivariable linear regression model. In the model adjusted for age and race, the serum testosterone level was negatively associated with ALMI. However, in the models adjusted for body mass index, this association became positive. In addition, the association between the serum testosterone level and AFMI was negative in each multivariable linear regression model.
conclusionOur study demonstrated a positive association of serum testosterone level with lumbar BMD and ALMI, and a negative association with AFMI, among men 20-59 years of age, suggesting that increasing testosterone levels may be beneficial to skeletal health in young and middle-aged men with low testosterone levels.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.