Evidence map›Paper›PMID 34589082›Full record

ArticleFrontiers in immunology2021

MNSFβ Regulates TNFα Production by Interacting with RC3H1 in Human Macrophages, and Dysfunction of MNSFβ in Decidual Macrophages Is Associated With Recurrent Pregnancy Loss.

Xing-Xing Zhen, Long Yang, Yan Gu, Qian Yang, Wen-Wen Gu, Ya-Ping He, Yan-Ling Wang, Jian Wang

Open access · goldAbstract read
In one paragraph

Article in Frontiers in immunology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed, 1 pooled it
1.3field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 1 synthesis or guideline pooled it, 18 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Regulation of placental development and function by ubiquitination.Molecular medicine (Cambridge, Mass.) · 2025
    Review
  4. Article
  5. Article
  6. Article
  7. Article
  8. SEC5 is involved in M2 polarization of macrophagesFrontiers in cell and developmental biology · 2022
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 5 institutions in 1 country.

Xing-Xing ZhenNational Health Commission (NHC) of the People's Republic of China Key Lab of Reproduction Regulation (Shanghai Institute for Biomedical and Pharmaceutical Technologies), School of Pharmacy, Fudan University, Shanghai, China.
Long YangNational Health Commission (NHC) of the People's Republic of China Key Lab of Reproduction Regulation (Shanghai Institute for Biomedical and Pharmaceutical Technologies), School of Pharmacy, Fudan University, Shanghai, China.
Yan GuDepartment of Gynecology and Obstetrics, The Second Hospital of Tianjin Medical University, Tianjin, China.
Qian YangNational Health Commission (NHC) of the People's Republic of China Key Lab of Reproduction Regulation (Shanghai Institute for Biomedical and Pharmaceutical Technologies), School of Pharmacy, Fudan University, Shanghai, China.
Wen-Wen GuNational Health Commission (NHC) of the People's Republic of China Key Lab of Reproduction Regulation (Shanghai Institute for Biomedical and Pharmaceutical Technologies), School of Pharmacy, Fudan University, Shanghai, China.
Ya-Ping HeNational Health Commission (NHC) of the People's Republic of China Key Lab of Reproduction Regulation (Shanghai Institute for Biomedical and Pharmaceutical Technologies), School of Pharmacy, Fudan University, Shanghai, China.
Yan-Ling WangState Key Laboratory of Stem Cell and Reproductive Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing, China.
Jian WangNational Health Commission (NHC) of the People's Republic of China Key Lab of Reproduction Regulation (Shanghai Institute for Biomedical and Pharmaceutical Technologies), School of Pharmacy, Fudan University, Shanghai, China.
National Health and Family Planning Commission · CNChinese Academy of Sciences · CNFudan University · CNSecond Hospital of Tianjin Medical University · CNUniversity of Chinese Academy of Sciences · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Decidual macrophages (dMϕ) are the second largest population of leukocytes at the maternal-fetal interface and play critical roles in maintaining pregnancy. Our previous studies demonstrated the active involvement of monoclonal nonspecific suppressor factor-β (MNSFβ) in embryonic implantation and pregnancy success. MNSFβ is a ubiquitously expressed ubiquitin-like protein that also exhibits immune regulatory potential, but its function in human dMϕ remains unknown. Here, we observed that the proportion of CD11c

Indexed as

Abortion, HabitualAdultCells, CulturedDeciduaFemaleHumansMacrophagesPregnancyRNA-Binding ProteinsSuppressor Factors, ImmunologicTumor Necrosis Factor-alphaUbiquitin-Protein Ligasesmonoclonal nonspecific suppressor factorRC3H1 protein, humanRNA-Binding ProteinsSuppressor Factors, ImmunologicTNF protein, humanTumor Necrosis Factor-alphaUbiquitin-Protein Ligasesdecidual macrophagesMNSFβRC3H1recurrent pregnancy lossTNFα

Identifiers

PMID34589082
PMCPMC8473736
OpenAlexW3201000054

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.