ReviewFrontiers in psychology2021
Social Support and Longevity: Meta-Analysis-Based Evidence and Psychobiological Mechanisms.
Review in Frontiers in psychology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 90 papers, 5 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
90 citing papers in PubMed, 5 syntheses or guidelines pooled it.
- The Associations Between Social Support and Problematic Mobile Phone Use Among Children and Adolescents: A Three-level Meta-analysis.Journal of youth and adolescence · 2025Pooled it
- The association between social support and prosocial behavior: A three-level meta-analysis.PsyCh journal · 2024Pooled it
- A Systematic Review and Meta-Analysis of the Association Between Physical Capability, Social Support, Loneliness, Depression, Anxiety, and Life Satisfaction in Older Adults.The Gerontologist · 2024Pooled it
- Socially-supported sleep in older adults aged 50 and older: a concept analysis.Frontiers in public health · 2024Pooled it
- Peer support interventions in patients with kidney failure: A systematic review.Journal of psychosomatic research · 2023Pooled it
- Relationships Among Heart Rate Variability, Perceived Social Support, and Hopelessness in Adults With Ischemic Heart Disease.Journal of the American Heart Association · 2024Trial
- Article
- Plasma proteomic signatures of social support and their association with cardiovascular disease and mortality: exploratory analyses in a national cohort study.GeroScience · 2026Article
- Perceived Social Support Moderates the Response to Stress and Alcohol Cues During Early Abstinence From Alcohol.Biological psychiatry global open science · 2026Article
- A new taxonomy of social support: Clarifying supportive behaviours and measures.Journal of health psychology · 2026Review
- Clowning in care: long-term effectiveness of clown visits on residents' affect, resilience, sleep quality and functionality.BMC geriatrics · 2026Article
- A Healthy Lifestyle Can Slow Immune System Aging and Reduce Age-Related Chronic Inflammation: A Narrative Review.International journal of molecular sciences · 2026Review
- Social Support Across the Cancer Care Continuum in Malawi: Narratives from Cancer Survivors.SSM. Qualitative research in health · 2026Article
- Living Alone as a Persistent Risk Factor for Smoking and High-Risk Drinking: A Three-Year Repeated Cross-Sectional Analysis Before and During the COVID-19 Pandemic in the Republic of Korea.Healthcare (Basel, Switzerland) · 2026Article
- Predictors and Trajectories of Negative and Positive Interpersonal Dynamics in Remission From Alcohol Use Disorder.Alcohol, clinical & experimental research · 2026Article
- Psychosocial risk and protective factors for men's lower urinary tract symptoms: A secondary analysis of CARDIA cohort study data.Journal of health psychology · 2026Article
- Effects of Social Support Interventions on Medical Patient Survival: A Meta-Analysis of Non-Randomized Clinical Trials.Healthcare (Basel, Switzerland) · 2026Review
- The WONE Index as a Multidimensional Assessment of Stress Resilience: A Development and Validation Study.Journal of medical Internet research · 2026Article
- Longevity, Centenarians, and Lifestyle: Any ''Tips'' to Live Longer?Current nutrition reports · 2026Review
- Predictors of resilience in deaf and hard of hearing adolescents and adolescents with developmental language disorders.Frontiers in psychology · 2026Article
30 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Over the past 60 years, evidence has accumulated on the fundamental role of supportive social relationships in individual health and longevity. This paper first summarizes the results of 23 meta-analyses published between 1994 and 2021, which include 1,187 longitudinal and cross-sectional studies with more than 1,458 million participants. The effect sizes reported in these meta-analyses are highly consistent with regard to the predicted link between social support and reduced disease and mortality; the meta-analyses also highlight various theoretical and methodological issues concerning the multi-dimensionality of the social support concept and its measurements, and the need to control potential confounding and moderator variables. This is followed by an analysis of the experimental evidence from laboratory studies on psychobiological mechanisms that may explain the effect of social support on health and longevity. The stress-buffering hypothesis is examined and extended to incorporate recent findings on the inhibitory effect of social support figures (e.g., the face of loved ones) on fear learning and defensive reactions alongside evidence on the effect of social support on brain networks that down-regulate the autonomic nervous system, HPA axis, and immune system. Finally, the paper discusses the findings in the context of three emerging research areas that are helping to advance and consolidate the relevance of social factors for human health and longevity: (a) convergent evidence on the effects of social support and adversity in other social mammals, (b) longitudinal studies on the impact of social support and adversity across each stage of the human lifespan, and (c) studies that extend the social support framework from individual to community and societal levels, drawing implications for large-scale intervention policies to promote the culture of social support.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.