Evidence map›Paper›PMID 34588851›Full record

ArticleSaudi pharmaceutical journal : SPJ : the official publication of the Saudi Pharmaceutical Society2021

Phytomodulatory proteins isolated from Calotropis procera latex promote glycemic control by improving hepatic mitochondrial function in HepG2 cells.

Keciany Alves de Oliveira, Hygor Nunes Araújo, Tanes Iamamura de Lima, André Gustavo Oliveira, Bianca Cristine Favero-Santos, Dimitrius Santiago P S F Guimarães, Paula Alexandre de Freitas, Regina de Jesus das Neves, Renata Prado Vasconcelos, Marina Gabrielle Guimarães de Almeida and 3 more

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Saudi pharmaceutical journal : SPJ : the official publication of the Saudi Pharmaceutical Society, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.5field-weighted citation impact, top 41% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 8 citations in OpenAlex.

  1. Review
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 2 institutions in 1 country.

Keciany Alves de OliveiraSuperior Institute of Biomedical Sciences, State University of Ceara, Fortaleza, Brazil.
Hygor Nunes AraújoResearch Center on Obesity and Comorbidities, Campinas, Brazil.
Tanes Iamamura de LimaResearch Center on Obesity and Comorbidities, Campinas, Brazil.
André Gustavo OliveiraResearch Center on Obesity and Comorbidities, Campinas, Brazil.
Bianca Cristine Favero-SantosResearch Center on Obesity and Comorbidities, Campinas, Brazil.
Dimitrius Santiago P S F GuimarãesResearch Center on Obesity and Comorbidities, Campinas, Brazil.
Paula Alexandre de FreitasSuperior Institute of Biomedical Sciences, State University of Ceara, Fortaleza, Brazil.
Regina de Jesus das NevesSuperior Institute of Biomedical Sciences, State University of Ceara, Fortaleza, Brazil.
Renata Prado VasconcelosSuperior Institute of Biomedical Sciences, State University of Ceara, Fortaleza, Brazil.
Marina Gabrielle Guimarães de AlmeidaDepartment of Biochemistry and Molecular Biology, Fortaleza, Brazil.
Márcio Viana RamosDepartment of Biochemistry and Molecular Biology, Fortaleza, Brazil.
Leonardo Reis SilveiraResearch Center on Obesity and Comorbidities, Campinas, Brazil.
Ariclecio Cunha de OliveiraSuperior Institute of Biomedical Sciences, State University of Ceara, Fortaleza, Brazil.
Universidade Estadual do Ceará · BRUniversidade de Fortaleza · BR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The medicinal uses of Calotropis procera are diverse, yet some of them are based on effects that still lack scientific support. Control of diabetes is one of them. Recently, latex proteins from

Indexed as

AMPK, AMP-activated kinase proteinAUC, Area under the curveBioactive proteinsCalotropis proceraCpPII, Major peptidase fraction treated with iodoacetamideCTL, ControlDHE, DihydroethidiumDMEM, Dulbecco’s minimal essential mediumDMSO, Dimethyl sulfoxideFCCP, Oligomycin carbonyl cyanide 4 (trifluoromethoxy) phenylhydrazineFolk medicineGlycemiaHGP, Hepatic glucose productionLatexLP, Soluble latex proteins from Calotropis proceraMTT, 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromideOCR, Oxygen consumption rateOXPHOS, Oxidative phosphorylationPPAR, Peroxisome proliferator-activated receptorPPRE, PPAR response elementROS, Reactive oxygen speciesTBS-T, Tris buffered saline solution containing 0.1% Tween 20UCP2, Mitochondrial uncoupling protein 2

Identifiers

PMID34588851
PMCPMC8463474
OpenAlexW3186026819

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.