Evidence map›Paper›PMID 34588805›Full record

ArticleInternational journal of general medicine2021

IRF4 is Correlated with the Conversion to a Th17-Like Phenotype in Regulatory T Cells from the Malignant Pleural Effusion.

Wenqing Yu, Ningfei Ji, Chengjing Gu, Juan Yao, Mingdong Ding, Daming Zhou, Mao Huang, Mingshun Zhang

Open access · goldAbstract read
In one paragraph

Article in International journal of general medicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
1.5field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 10 citations in OpenAlex.

  1. Article
  2. Review
  3. Analysis of CD4Gland surgery · 2023
    Article
  4. T cells in health and disease.Signal transduction and targeted therapy · 2023
    Review
  5. Article
  6. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 4 institutions in 1 country.

Wenqing Yu *Department of Infectious Diseases, Taizhou People's Hospital Affiliated to Nantong University, Taizhou, Jiangsu, 225300, People's Republic of China.ORCID 0000-0002-3046-4485
Ningfei Ji *Department of Respiratory and Critical Care Medicine, The First Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu, 210029, People's Republic of China.
Chengjing Gu *Department of Pharmacy, Taizhou People's Hospital Affiliated to Nantong University, Taizhou, Jiangsu, 225300, People's Republic of China.
Juan YaoDepartment of Oncology, Huaian Hospital of Huaian City, Huaian, Jiangsu, 223200, People's Republic of China.
Mingdong DingDepartment of Infectious Diseases, Taizhou People's Hospital Affiliated to Nantong University, Taizhou, Jiangsu, 225300, People's Republic of China.
Daming ZhouDepartment of Infectious Diseases, Taizhou People's Hospital Affiliated to Nantong University, Taizhou, Jiangsu, 225300, People's Republic of China.
Mao HuangDepartment of Respiratory and Critical Care Medicine, The First Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu, 210029, People's Republic of China.
Mingshun ZhangDepartment of Immunology, Nanjing Medical University, Nanjing, Jiangsu, 211166, People's Republic of China.ORCID 0000-0001-5925-0168
Nantong University · CNJiangsu Province Hospital · CNHuaian First People’s Hospital · CNNanjing Medical University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundRORγt

methodsThe percentage of CD4

resultsThe frequency of CD4

conclusionIRF4 may serve as a potential molecule that promotes the conversion of regulatory T cells from MPE to a Th17-like phenotype by modulating Helios.

Indexed as

IRF4lung cancermalignant pleural effusionphenotypic transformationregulatory T cells

Identifiers

PMID34588805
PMCPMC8476179
OpenAlexW3201440938

What OpenQuestion holds

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LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.