ArticleNature2021
Circadian autophagy drives iTRF-mediated longevity.
Registry-linked trialOpen access · bronzeAbstract read
In one paragraph
Article in Nature, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05732935 (Fasting to Provide Energy Needed to Help Adults in Need of Cognitive Enhancement), which is not on this map. Cited by 132 papers.
0numbers the graph read from it
0cells of the map it votes in
132citing papers in PubMed
18.7field-weighted citation impact, top 1% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Fasting to Provide Energy Needed to Help Adults in Need of Cognitive Enhancement (FASTING ENHANCE)
Who cites it
132 citing papers in PubMed, 210 citations in OpenAlex.
- The Effects of Time-Restricted Feeding and Exercise on Cardiometabolic Health in Sedentary Older Adults: A Randomized Controlled Trial.Medicine and science in sports and exercise · 2026Trial
- Do the Effects of Early Time-Restricted Eating Vary by Cardiometabolic Phenotype, Age, Sex, or Race? A Secondary Analysis of a Randomized Controlled Trial.The Journal of nutrition · 2026Trial
- Early Time-Restricted Eating Improves Weight Loss While Preserving Muscle: An 8-Week Trial in Young Women.Nutrients · 2025Trial
- Effects of time-restricted feeding and walking exercise on the physical health of female college students with hidden obesity: a randomized trial.Frontiers in public health · 2023Trial
- Time-restricted eating with or without low-carbohydrate diet reduces visceral fat and improves metabolic syndrome: A randomized trial.Cell reports. Medicine · 2022Trial
- Dietary Modulation of CMA: Implications for Cancer Prevention and Therapy.Physiology (Bethesda, Md.) · 2027Review
- Increasing autophagy with fasting and diet: separating fact from fiction.Biochemical Society transactions · 2026Review
- Timing of food intake impacts cardiovascular and neuroendocrine physiology and risk of disease.Cardiovascular research · 2026Review
- Clinical Protocol for the Dietary Approaches to Longevity and Health (DiAL Health) Pilot Trial.Current developments in nutrition · 2026Article
- Phosphorylation of OTUB1 promotes autophagy initiation under starvation.Nature communications · 2026Article
- Article
- A deep learning and large language hybrid workflow for omics interpretation.Nature biomedical engineering · 2026Article
- Gut Metabolism Links Precision Nutrition, Exercise, and Healthspan in Drosophila melanogaster.Aging cell · 2026Article
- Time-restricted feeding puts mouse healthspan on the clock.Nature aging · 2026Article
- Aging-Related Muscle Bmal1 Decline Contributes to Bone Loss in Mice via Enhancing IL-1α-Mediated Osteoclastogenesis.Aging cell · 2026Article
- Gut Lactate Boosts Ruminococcus via Histone Lactylation to Mediate Time-Restricted Feeding Protection in Crohn's Disease.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Circadian biology and exercise: the time to move.Life metabolism · 2026Review
- Time-restricted feeding extends healthspan in both sexes and lifespan in male C57BL/6 J mice.Nature aging · 2026Article
- Noncanonical clock regulators control stress responses in digestive diseases.Trends in endocrinology and metabolism: TEM · 2026Review
- Bidirectional regulation between circadian feeding behavior and specialized midgut clocks inbioRxiv : the preprint server for biology · 2026Article
72 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
10 authors at 3 institutions in 2 countries.
Matt UlgheraitDepartment of Genetics and Development, Columbia University Vagelos College of Physicians and Surgeons, New York, NY, USA.
Adil M MidounDepartment of Biology, École Normale Supérieure, PSL Research University, Paris, France.
Scarlet J ParkSkaggs Graduate School, The Scripps Research Institute, Jupiter, FL, USA.ORCID http://orcid.org/0000-0002-1545-6284
Jared A GattoDepartment of Genetics and Development, Columbia University Vagelos College of Physicians and Surgeons, New York, NY, USA.
Samantha J TenerDepartment of Genetics and Development, Columbia University Vagelos College of Physicians and Surgeons, New York, NY, USA.ORCID http://orcid.org/0000-0003-4367-7372
Julia SiewertDepartment of Genetics and Development, Columbia University Vagelos College of Physicians and Surgeons, New York, NY, USA.
Naomi KlicksteinDepartment of Biological Sciences, Columbia University, New York, NY, USA.
Julie C CanmanDepartment of Pathology and Cell Biology, Columbia University Vagelos College of Physicians and Surgeons, New York, NY, USA.
William W JaSkaggs Graduate School, The Scripps Research Institute, Jupiter, FL, USA.ORCID http://orcid.org/0000-0002-4003-7356
Mimi Shirasu-HizaDepartment of Genetics and Development, Columbia University Vagelos College of Physicians and Surgeons, New York, NY, USA. ms4095@cumc.columbia.edu.ORCID http://orcid.org/0000-0002-2730-1765
Columbia University · USScripps Research Institute · USUniversité Paris Sciences et Lettres · FR
Funding
Resource Component: Acquisition, maintenance and distribution of Drosophila stocksP40OD018537 · OD · TRUSTEES OF INDIANA UNIVERSITY · PI Annette L. Parks · 2014 to 2026
$13.5MPREDOCTORAL TRAINING GRANT IN HUMAN GENETICS &DEVELOPMET32GM007088 · NIGMS · COLUMBIA UNIV NEW YORK MORNINGSIDE · PI SHEN, MICHAEL M. · 1985 to 2020
$7.1MCircadian-Regulated Aging PhysiologiesR01AG045842 · NIA · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI Michele M Shirasu-Hiza · 2013 to 2026
$5.1MCircadian regulation of physiological functionsR35GM127049 · NIGMS · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI Michele M Shirasu-Hiza · 2018 to 2026
$3.9MCell type-variation of cytokinesisR01GM117407 · NIGMS · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI CANMAN, JULIE C · 2016 to 2023
$2.9MGenetic Approaches to Development and DiseaseT32GM141882 · NIGMS · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI BERCHOWITZ, LUKE E, SHIRASU-HIZA, MICHELE M · 2021 to 2025
$2.1MCircadian regulation of phagocytosisR01GM105775 · NIGMS · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI SHIRASU-HIZA, MICHELE M · 2013 to 2017
$1.6MProbing the spatiotemporal regulation of cell divisionR01GM130764 · NIGMS · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI CANMAN, JULIE C · 2019 to 2022
$1.3MCircadian regulation of feeding behaviorR56AG065986 · NIA · SCRIPPS FLORIDA · PI JA, WILLIAM W · 2019 to 2019
$463kNIA NIH HHS R01 AG045842NIA NIH HHS R56 AG065986NIGMS NIH HHS R01 GM105775NIGMS NIH HHS R01 GM117407NIGMS NIH HHS R01 GM130764NIGMS NIH HHS R35 GM127049NIGMS NIH HHS T32 GM007088NIGMS NIH HHS T32 GM141882NIH HHS P40 OD018537
Abstract
Time-restricted feeding (TRF) has recently gained interest as a potential anti-ageing treatment for organisms from Drosophila to humans
Indexed as
AgingAnimalsAutophagyBiomarkersCircadian ClocksCircadian RhythmDarknessDrosophila melanogasterFeeding BehaviorFemaleLongevityMaleTime FactorsBiomarkers
Identifiers
What OpenQuestion holds
Textmetadata
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Read underepoch 390
Registered trials
NCT05732935ClinicalTrials.gov
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.