ArticleNature2021
Structure-based classification of tauopathies.
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Article in Nature, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 519 papers.
0numbers the graph read from it
0cells of the map it votes in
519citing papers in PubMed
82.7field-weighted citation impact, top 1% of its field
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
519 citing papers in PubMed, 882 citations in OpenAlex.
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- Brain organoids in Alzheimer disease and related tauopathies: Challenges and opportunities for translational readiness.Stem cell reports · 2026Review
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- Tau Aggregate Imaging and Transcriptomics of Alzheimer's Disease Brain at Different Stages of Disease.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Protocol for efficient purification of endotoxin-free human recombinant tau protein.STAR protocols · 2026Article
- Multipathway Aggregation Drives Concentration-Dependent Amyloid Polymorphism and Time-Dependent Morphological Evolution.The journal of physical chemistry letters · 2026Article
- A third-generation, high-affinity biparatopic anti-tau antibody inhibits intracellular tau aggregation seeded by Alzheimer's brain extracts.Alzheimer's research & therapy · 2026Article
- Amplification of seeding-competent tau aggregates by PMCA in human and experimental tauopathies.Acta neuropathologica communications · 2026Article
- Toward the prevention of clinically manifest Parkinson's disease.Journal of neural transmission (Vienna, Austria : 1996) · 2026Review
- Proteomic comparison of hippocampal neurofibrillary tangles in PART, intermediate Alzheimer's disease and advanced Alzheimer's disease.Acta neuropathologica · 2026Article
- Distinct amyloid-β filament fold in individuals with APP Flemish mutation.Nature structural & molecular biology · 2026Article
- Emerging Trends and Hot Spots in Tauopathy Research (2003-2025): A Bibliometric Analysis.Brain and behavior · 2026Article
- Cryo-EM structures of biopsy-derived TTR fibrils in hereditary transthyretin amyloidosis.Nature communications · 2026Article
- Metal Binding to Tau Protein: Physiological and Pathological Relevance.Biochemistry · 2026Review
- MAPT-derived circTau6 induces tau pathogenesis and neurodegeneration by encoding Tau variants.Molecular psychiatry · 2026Article
459 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
27 authors at 10 institutions in 6 countries.
Yang Shi *MRC Laboratory of Molecular Biology, Cambridge, UK.ORCID http://orcid.org/0000-0003-1579-7561
Wenjuan Zhang *MRC Laboratory of Molecular Biology, Cambridge, UK.
Yang YangMRC Laboratory of Molecular Biology, Cambridge, UK.
Alexey G MurzinMRC Laboratory of Molecular Biology, Cambridge, UK.
Benjamin FalconMRC Laboratory of Molecular Biology, Cambridge, UK.
Abhay KotechaThermo Fisher Scientific, Eindhoven, The Netherlands.ORCID http://orcid.org/0000-0002-4480-5439
Mike van BeersThermo Fisher Scientific, Eindhoven, The Netherlands.
Airi TarutaniDepartment of Brain and Neurosciences, Tokyo Metropolitan Institute of Medical Science, Tokyo, Japan.
Fuyuki KametaniDepartment of Brain and Neurosciences, Tokyo Metropolitan Institute of Medical Science, Tokyo, Japan.ORCID http://orcid.org/0000-0001-9125-7001
Holly J GarringerDepartment of Pathology and Laboratory Medicine, Indiana University School of Medicine, Indianapolis, IN, USA.ORCID http://orcid.org/0000-0002-1899-7676
Ruben VidalDepartment of Pathology and Laboratory Medicine, Indiana University School of Medicine, Indianapolis, IN, USA.
Grace I HallinanDepartment of Pathology and Laboratory Medicine, Indiana University School of Medicine, Indianapolis, IN, USA.
Tammaryn LashleyDepartment of Neurodegenerative Disease and Queen Square Brain Bank for Neurological Disorders, UCL Queen Square Institute of Neurology, London, UK.
Yuko SaitoDepartment of Neuropathology, Tokyo Metropolitan Geriatric Hospital and Institute of Gerontology, Tokyo, Japan.
Shigeo MurayamaMolecular Research Center for Children's Mental Development, United Graduate School of Child Development, University of Osaka, Osaka, Japan.
Mari YoshidaInstitute for Medical Science of Aging, Aichi Medical University, Nagakute, Japan.
Hidetomo TanakaDepartment of Pathology, Brain Research Institute, Niigata University, Niigata, Japan.ORCID http://orcid.org/0000-0002-8490-3877
Akiyoshi KakitaDepartment of Pathology, Brain Research Institute, Niigata University, Niigata, Japan.
Takeshi IkeuchiDepartment of Molecular Genetics, Brain Research Institute, Niigata University, Niigata, Japan.ORCID http://orcid.org/0000-0001-8828-8085
Andrew C RobinsonClinical Sciences Building, University of Manchester, Salford Royal Foundation Trust, Salford, UK.ORCID http://orcid.org/0000-0003-2208-7728
David M A MannClinical Sciences Building, University of Manchester, Salford Royal Foundation Trust, Salford, UK.
Gabor G KovacsDepartment of Laboratory Medicine and Pathobiology and Tanz Centre for Research in Neurodegenerative Diseases, University of Toronto, Toronto, Ontario, Canada.ORCID http://orcid.org/0000-0003-3841-5511
Tamas ReveszDepartment of Neurodegenerative Disease and Queen Square Brain Bank for Neurological Disorders, UCL Queen Square Institute of Neurology, London, UK.
Bernardino GhettiDepartment of Pathology and Laboratory Medicine, Indiana University School of Medicine, Indianapolis, IN, USA.ORCID http://orcid.org/0000-0002-1842-8019
Masato HasegawaDepartment of Brain and Neurosciences, Tokyo Metropolitan Institute of Medical Science, Tokyo, Japan.ORCID http://orcid.org/0000-0001-7415-8159
Michel GoedertMRC Laboratory of Molecular Biology, Cambridge, UK. mg@mrc-lmb.cam.ac.uk.ORCID http://orcid.org/0000-0002-5214-7886
Sjors H W ScheresMRC Laboratory of Molecular Biology, Cambridge, UK. scheres@mrc-lmb.cam.ac.uk.ORCID http://orcid.org/0000-0002-0462-6540
MRC Laboratory of Molecular Biology · GBIndiana University School of MedicineNiigata University · JPTokyo Metropolitan Institute of Medical Science · JPNational Hospital for Neurology and Neurosurgery · GBSalford Royal NHS Foundation Trust · GBThermo Fisher Scientific (Netherlands) · NLAichi Medical University · JPTokyo Metropolitan Geriatric Hospital · JPUniversity of Toronto · CA
Funding
Research Education ComponentP30AG010133 · NIA · INDIANA UNIV-PURDUE UNIV AT INDIANAPOLIS · PI SAYKIN, ANDREW J · 1991 to 2020
$37.3MResearch Education ComponentP30AG072976 · NIA · INDIANA UNIVERSITY INDIANAPOLIS · PI ANDREW J SAYKIN · 2021 to 2026
$24.1MAtomic models of human tau filaments and development of tau ligandsU01NS110437 · NINDS · INDIANA UNIVERSITY INDIANAPOLIS · PI GHETTI, BERNARDINO FRANCESCO, JIANG, WEN · 2018 to 2022
$3.5MStructural analysis of tau associated with parenchymal and vascular prion protein amyloidosisRF1AG071177 · NIA · INDIANA UNIVERSITY INDIANAPOLIS · PI GHETTI, BERNARDINO FRANCESCO, JIANG, WEN · 2021 to 2021
$2.3MMedical Research Council MC_U105184291Medical Research Council MC_U105192716Medical Research Council MC_UP_A025_1013NIA NIH HHS P30 AG010133NIA NIH HHS P30 AG072976NIA NIH HHS RF1 AG071177NINDS NIH HHS U01 NS110437Wellcome Trust
Abstract
The ordered assembly of tau protein into filaments characterizes several neurodegenerative diseases, which are called tauopathies. It was previously reported that, by cryo-electron microscopy, the structures of tau filaments from Alzheimer's disease
Indexed as
Cryoelectron MicroscopyProtein FoldingAgedAged, 80 and overAmino Acid SequenceDementiaDenmarkFemaleHumansIntronsMaleMiddle AgedModels, MolecularMutationProtein IsoformsSupranuclear Palsy, ProgressiveMAPT protein, humanProtein Isoformstau Proteins
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.