Evidence map›Paper›PMID 34588632›Full record

ArticleCell death and differentiation2022

Foxo3a tempers excessive glutaminolysis in activated T cells to prevent fatal gut inflammation in the murine IL-10

Stephanie Hajjar, Nayanan Nathan, Julie Joseph, Walid Mottawea, Ardeshir Ariana, Sergey Pyatibrat, Mary-Ellen Harper, Tommy Alain, Alexandre Blais, Ryan C Russell and 1 more

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cell death and differentiation, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.4field-weighted citation impact, top 40% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 8 citations in OpenAlex.

  1. Article
  2. Gut-Brain Signaling in Parkinson's Disease: A Narrative Review.International journal of molecular sciences · 2026
    Review
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 2 institutions in 2 countries.

Stephanie HajjarDepartment of Biochemistry, Microbiology and Immunology, University of Ottawa, Ottawa, ON, Canada.ORCID http://orcid.org/0000-0001-9740-3487
Nayanan NathanDepartment of Biochemistry, Microbiology and Immunology, University of Ottawa, Ottawa, ON, Canada.ORCID http://orcid.org/0000-0002-1408-5661
Julie JosephDepartment of Biochemistry, Microbiology and Immunology, University of Ottawa, Ottawa, ON, Canada.
Walid MottaweaFaculty of Health Sciences, School of Nutrition Sciences, University of Ottawa, Ottawa, ON, Canada.ORCID http://orcid.org/0000-0003-1260-2140
Ardeshir ArianaDepartment of Biochemistry, Microbiology and Immunology, University of Ottawa, Ottawa, ON, Canada.
Sergey PyatibratDepartment of Pathology and Laboratory Medicine, Royal Columbian Hospital, New Westminster, BC, Canada.
Mary-Ellen HarperDepartment of Biochemistry, Microbiology and Immunology, University of Ottawa, Ottawa, ON, Canada.ORCID http://orcid.org/0000-0003-3864-5886
Tommy AlainDepartment of Biochemistry, Microbiology and Immunology, University of Ottawa, Ottawa, ON, Canada.ORCID http://orcid.org/0000-0002-0396-9138
Alexandre BlaisDepartment of Biochemistry, Microbiology and Immunology, University of Ottawa, Ottawa, ON, Canada.ORCID http://orcid.org/0000-0003-2446-1883
Ryan C RussellUniversity of Ottawa Centre for Infection, Immunity and Inflammation, Ottawa, ON, Canada.
Subash SadDepartment of Biochemistry, Microbiology and Immunology, University of Ottawa, Ottawa, ON, Canada. Subash.sad@uottawa.ca.ORCID http://orcid.org/0000-0002-2462-7137
University of Ottawa · CARoyal Columbian Hospital · CA

Funding

CIHR 420007
6 · The paper itself

Abstract

Mutations in susceptibility alleles correlate with gut-inflammatory diseases, such as Crohn's disease; however, this does not often impact the disease progression indicating the existence of compensatory genes. We show that a reduction in Foxo3a expression in IL-10-deficient mice results in a spontaneous and aggressive Crohn's- like disease with 100% penetrance, which is rescued by deletion of myeloid cells, T cells and inhibition of mTORC1. In Foxo3a

Indexed as

ColitisInterleukin-10AnimalsForkhead Box Protein O3InflammationMechanistic Target of Rapamycin Complex 1MiceT-LymphocytesForkhead Box Protein O3FoxO3 protein, mouseInterleukin-10Mechanistic Target of Rapamycin Complex 1

Identifiers

PMID34588632
PMCPMC8901686
OpenAlexW3203481044

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.