ArticleScientific reports2021
Transcranial focused ultrasound modulates cortical and thalamic motor activity in awake sheep.
Article in Scientific reports, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06681610 (Modulation of the Motor Pathway by Transcranial Pulse Stimulation in People With ALS), which is not on this map. Cited by 25 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Modulation of the Motor Pathway by Transcranial Pulse Stimulation in People With ALS: a Pilot Randomized Trial
Who cites it
25 citing papers in PubMed, 41 citations in OpenAlex.
- Ultrasound Modulation of Visual Circuits in Mice Independent of Auditory Confound.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- A panoramic review of transcranial focused ultrasound neuromodulation: from basic research to clinical applications.Journal of neuroengineering and rehabilitation · 2025Review
- Transcranial Focused Ultrasound Modulates Visual Thalamus in a Nonhuman Primate Model.IEEE transactions on bio-medical engineering · 2025Article
- Transcranial Focused Ultrasound Modulates Feedforward and Feedback Cortico-Thalamo-Cortical Pathways by Selectively Activating Excitatory Neurons.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025Article
- Parameter-dependent cell-type specific effects of transcranial focused ultrasound stimulation in an awake head-fixed rodent model.Journal of neural engineering · 2025Article
- Emerging Wearable Acoustic Sensing Technologies.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Review
- Transcranial focused ultrasound to nucleus accumbens reverses fentanyl-induced conditioned place preference in rats.PloS one · 2025Article
- Transcranial focused ultrasound remotely modulates extrastriate visual cortex by stimulating frontal eye field with subregion specificity.Journal of neural engineering · 2024Article
- Focal Volume, Acoustic Radiation Force, and Strain in Two-Transducer Regimes.IEEE transactions on ultrasonics, ferroelectrics, and frequency control · 2024Article
- Towards an ion-channel-centric approach to ultrasound neuromodulation.Current opinion in behavioral sciences · 2024Article
- Non-invasive enhancement of intracortical solute clearance using transcranial focused ultrasound.Scientific reports · 2023Article
- Transcranial focused ultrasound-mediated unbinding of phenytoin from plasma proteins for suppression of chronic temporal lobe epilepsy in a rodent model.Scientific reports · 2023Article
- Weak Ultrasound Contributes to Neuromodulatory Effects in the Rat Motor Cortex.International journal of molecular sciences · 2023Article
- Transcranial focused ultrasound stimulation of cortical and thalamic somatosensory areas in human.PloS one · 2023Article
- Low-Intensity Focused Ultrasound Neuromodulation for Stroke Recovery: A Novel Deep Brain Stimulation Approach for Neurorehabilitation?IEEE open journal of engineering in medicine and biology · 2023Article
- Safety of Clinical Ultrasound Neuromodulation.Brain sciences · 2022Review
- Transcranial ultrasound neuromodulation induces neuronal correlation change in the rat somatosensory cortex.Journal of neural engineering · 2022Article
- Enhancement of cerebrospinal fluid tracer movement by the application of pulsed transcranial focused ultrasound.Scientific reports · 2022Article
- Translational approaches to influence sleep and arousal.Brain research bulletin · 2022Review
- Low Intensity Focused Ultrasound for Epilepsy- A New Approach to Neuromodulation.Epilepsy currents · 2022Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 3 institutions in 1 country.
Funding
Abstract
Transcranial application of pulsed low-intensity focused ultrasound (FUS) modulates the excitability of region-specific brain areas, and anesthetic confounders on brain activity warrant the evaluation of the technique in awake animals. We examined the neuromodulatory effects of FUS in unanesthetized sheep by developing a custom-fit headgear capable of reproducibly placing an acoustic focus on the unilateral motor cortex (M1) and corresponding thalamic area. The efferent responses to sonication, based on the acoustic parameters previously identified in anesthetized sheep, were measured using electromyography (EMG) from both hind limbs across three experimental conditions: on-target sonication, off-target sonication, and without sonication. Excitatory sonication yielded greater amplitude of EMG signals obtained from the hind limb contralateral to sonication than that from the ipsilateral limb. Spurious appearance of motion-related EMG signals limited the amount of analyzed data (~ 10% selection of acquired data) during excitatory sonication, and the averaged EMG response rates elicited by the M1 and thalamic stimulations were 7.5 ± 1.4% and 6.7 ± 1.5%, respectively. Suppressive sonication, while sheep walked on the treadmill, temporarily reduced the EMG amplitude from the limb contralateral to sonication. No significant change was found in the EMG amplitudes during the off-target sonication. Behavioral observation throughout the study and histological analysis showed no sign of brain tissue damage caused by the acoustic stimulation. Marginal response rates observed during excitatory sonication call for technical refinement to reduce motion artifacts during EMG acquisitions as well as acoustic aberration correction schemes to improve spatial accuracy of sonication. Yet, our results indicate that low-intensity FUS modulated the excitability of regional brain tissues reversibly and safely in awake sheep, supporting its potential in theragnostic applications.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.