ArticleScientific reports2021
Morphological, biological, and genomic characterization of a newly isolated lytic phage Sfk20 infecting Shigella flexneri, Shigella sonnei, and Shigella dysenteriae1.
Article in Scientific reports, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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18 citing papers in PubMed, 27 citations in OpenAlex.
- Effects of Growth Stage and Physiological State on Gut Health, Antioxidant Capacity, and Muscle Nutritional Composition in Greenhouse-CulturedAntioxidants (Basel, Switzerland) · 2026Article
- Isolation, genomic characterization, and biofilm eradication activity of vB_PaP_DMTU_1, a novel lytic bacteriophage against Pseudomonas aeruginosa.Folia microbiologica · 2026Article
- Bacteriophage research in India and its implications for human health: A scoping review.The Indian journal of medical research · 2026Article
- Isolation and characterization of lyticFrontiers in cellular and infection microbiology · 2026Article
- Characterization and genomic analysis of DSF2: a novel lytic phage infecting multidrug-resistantFrontiers in microbiology · 2026Article
- Therapeutic potential of Shigella phage SSG23 against Shigella sonnei biofilms and in BALB/c mice.Npj viruses · 2025Article
- Utilizing the effectiveness of phage cocktail to combat Shigella and Salmonella infections and their polymicrobial biofilm control activity.BMC microbiology · 2025Article
- Recent insights on challenges encountered with phage therapy against gastrointestinal-associated infections.Gut pathogens · 2025Review
- Isolation and identification of bacteriophage against Escherichia coli ATCC 25922 and their biofilm Inhibition studies.Scientific reports · 2025Article
- Combined Forces Against Bacteria: Phages and Antibiotics.Health science reports · 2025Article
- Bacteriophage-based bioassays: an expected paradigm shift in microbial diagnostics.Future microbiology · 2024Review
- Physiochemical characterization of a potentialFrontiers in microbiology · 2024Article
- Controlling the bacterial load of Salmonella Typhi in an experimental mouse model by a lytic Salmonella phage STWB21: a phage therapy approach.BMC microbiology · 2023Article
- Isolation, Characterization, and Comparative Genomic Analysis of Bacteriophage Ec_MI-02 from Pigeon Feces InfectingInternational journal of molecular sciences · 2023Article
- Characterizations of novel broad-spectrum lytic bacteriophagesFrontiers in microbiology · 2023Article
- Biological properties of Staphylococcus virus ΦSA012 for phage therapy.Scientific reports · 2022Article
- Bacteriophages and Food Production: Biocontrol and Bio-Preservation Options for Food Safety.Antibiotics (Basel, Switzerland) · 2022Review
- Isolation, characterization, and application of a novel polyvalent lytic phage STWB21 against typhoidal and nontyphoidalFrontiers in microbiology · 2022Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Shigellosis, caused by Shigella bacterial spp., is one of the leading causes of diarrheal morbidity and mortality. An increasing prevalence of multidrug-resistant Shigella species has revived the importance of bacteriophages as an alternative therapy to antibiotics. In this study, a novel bacteriophage, Sfk20, has been isolated from water bodies of a diarrheal outbreak area in Kolkata (India) with lytic activity against many Shigella spp. Phage Sfk20 showed a latent period of 20 min and a large burst size of 123 pfu per infected cell in a one-step growth analysis. Phage-host interaction and lytic activity confirmed by phage attachment, intracellular phage development, and bacterial cell burst using ultrathin sectioning and TEM analysis. The genomic analysis revealed that the double-stranded DNA genome of Sfk20 contains 164,878 bp with 35.62% G + C content and 241 ORFs. Results suggested phage Sfk20 to include as a member of the T4 myoviridae bacteriophage group. Phage Sfk20 has shown anti-biofilm potential against Shigella species. The results of this study imply that Sfk20 has good possibilities to be used as a biocontrol agent.
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