Evidence map›Paper›PMID 34588540›Full record

ArticleScientific reports2021

Combination of FIB-4 with ultrasound surface nodularity or elastography as predictors of histologic advanced liver fibrosis in chronic liver disease.

Maryam Moini, Fernanda Onofrio, Bettina E Hansen, Oyedele Adeyi, Korosh Khalili, Keyur Patel

Abstract readComparative Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Maryam MoiniDivision of Gastroenterology and Hepatology, University Health Network, University of Toronto, Toronto General Hospital 9EN, 200 Elizabeth Street, Toronto, ON, M5G 2C4, Canada.
Fernanda OnofrioDivision of Gastroenterology and Hepatology, University Health Network, University of Toronto, Toronto General Hospital 9EN, 200 Elizabeth Street, Toronto, ON, M5G 2C4, Canada.
Bettina E HansenDivision of Gastroenterology and Hepatology, University Health Network, University of Toronto, Toronto General Hospital 9EN, 200 Elizabeth Street, Toronto, ON, M5G 2C4, Canada.
Oyedele AdeyiDepartment of Laboratory Medicine and Pathology, University of Minnesota, Minneapolis, USA.
Korosh KhaliliDepartment of Joint Medical Imaging, University Health Network, University of Toronto, Toronto, Canada.
Keyur PatelDivision of Gastroenterology and Hepatology, University Health Network, University of Toronto, Toronto General Hospital 9EN, 200 Elizabeth Street, Toronto, ON, M5G 2C4, Canada. keyur.patel@uhn.ca.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Reliable and available non-invasive methods for hepatic fibrosis assessment are important in chronic liver disease (CLD). Our aim was to compare stepwise algorithms combining standard ultrasound with serum markers and transient elastography (TE) for detecting advanced fibrosis (F3-4) and cirrhosis. Retrospective single center study between 2012 and 2018 of CLD patients with biopsy, TE, blood tests, and liver ultrasound parameters of surface nodularity (SN), lobar redistribution, and hepatic vein nodularity. Our cohort included 157 patients (51.6% males), mean age 47.6 years, predominantly non-alcoholic fatty liver disease and viral hepatitis (61%), with F3-4 prevalence of 60.5%. Area under the curve for F3-4 was 0.89 for TE ≥ 9.6 kPa and 0.80 for FIB-4 > 3.25. In multivariate modeling, TE ≥ 9.6 kPa (OR 21.78) and SN (OR 3.81) had independent association with F3-4; SN (OR 5.89) and TE ≥ 10.2 kPa (OR 15.73) were independently associated with cirrhosis. Two stepwise approaches included FIB-4 followed by SN or TE; sensitivity and specificity of stepwise SN were 0.65 and 1.00, and 0.89 and 0.33 for TE ≥ 9.6 kPa, respectively. Ultrasound SN and TE were independently predictive of F3-4 and cirrhosis in our cohort. FIB-4 followed by SN had high specificity for F3-4.

Indexed as

Elasticity Imaging TechniquesSeverity of Illness IndexAdultAlgorithmsBiomarkersBiopsyFemaleHepatitis, Viral, HumanHumansLiverLiver CirrhosisMaleMiddle AgedNon-alcoholic Fatty Liver DiseaseRetrospective StudiesROC CurveBiomarkers

Identifiers

PMID34588540
PMCPMC8481285

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