ArticleScientific reports2021
Rare and low-frequency exonic variants and gene-by-smoking interactions in pulmonary function.
Open access · goldAbstract read
In one paragraph
Article in Scientific reports, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers, 1 of them a synthesis that pooled it.
0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed, 1 pooled it
0.6field-weighted citation impact, top 31% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
5 citing papers in PubMed, 1 synthesis or guideline pooled it, 5 citations in OpenAlex.
- Kernel-based gene-environment interaction tests for rare variants with multiple quantitative phenotypes.PloS one · 2022Pooled it
- Genetic variants underpinning lung function decline in the Lifelines general population cohort study.ERJ open research · 2026Article
- Gene-based association study of rare variants in children of diverse ancestries implicates TNFRSF21 in the development of allergic asthma.The Journal of allergy and clinical immunology · 2024Article
- The COPD GWAS gene ADGRG6 instructs function and injury response in human iPSC-derived type II alveolar epithelial cells.American journal of human genetics · 2023Article
- Cauchy combination methods for the detection of gene-environment interactions for rare variants related to quantitative phenotypes.Heredity · 2023Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
47 authors at 20 institutions in 6 countries.
Tianzhong YangDepartment of Biostatistics and Data Science, School of Public Health, The University of Texas Health Science Center at Houston, Houston, TX, USA.
Victoria E JacksonDepartment of Health Sciences, University of Leicester, Leicester, UK.
Albert V SmithDepartment of Biostatistics, University of Michigan, Ann Arbor, MI, USA.
Han ChenHuman Genetics Center, Department of Epidemiology, Human Genetics and Environmental Sciences, School of Public Health, The University of Texas Health Science Center at Houston, Houston, TX, USA.
Traci M BartzDepartment of Biostatistics, University of Washington, Seattle, USA.
Colleen M SitlaniCardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle, WA, USA.
Bruce M PsatyCardiovascular Health Research Unit, Departments of Medicine, Epidemiology and Health Services, University of Washington, Seattle, WA, USA.
Sina A GharibDivision of Pulmonary, Critical Care, and Sleep, Department of Medicine, University of Washington, Seattle, WA, USA.
George T O'ConnorDepartment of Medicine, Pulmonary Center, Boston University School of Medicine, Boston, MA, USA.
Josée DupuisDepartment of Biostatistics, Boston University School of Public Health, Boston, MA, USA.
Jiayi XuPamela Sklar Division of Psychiatric Genomics, Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Kurt LohmanDivision of Cardiology, Department of Medicine, Duke Molecular Physiology Institute, Duke University School of Medicine, Durham, NC, USA.
Yongmei LiuDivision of Cardiology, Department of Medicine, Duke Molecular Physiology Institute, Duke University School of Medicine, Durham, NC, USA.
Stephen B KritchevskySticht Center for Healthy Aging and Alzheimer's Prevention, Wake Forest School of Medicine, Winston-Salem, NC, USA.
Patricia A CassanoDivision of Nutritional Sciences, Cornell University, Ithaca, NY, USA.
Claudia FlexederInstitute of Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany.
Christian GiegerResearch Unit of Molecular Epidemiology, Institute of Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany.
Stefan KarraschInstitute of Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany.
Annette PetersInstitute of Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany.
Holger SchulzInstitute of Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany.
Sarah E HarrisDepartment of Psychology, The University of Edinburgh, Edinburgh, UK.
John M StarrCentre for Cognitive Ageing and Cognitive Epidemiology, The University of Edinburgh, Edinburgh, UK.
Ian J DearyDepartment of Psychology, The University of Edinburgh, Edinburgh, UK.
Ani ManichaikulDepartment of Public Health Sciences, Center for Public Health Genomics, University of Virginia, Charlottesville, VA, USA.
Elizabeth C OelsnerDepartment of Medicine, College of Physicians and Surgeons, Columbia University, New York, NY, USA.
R G BarrDepartment of Epidemiology, Mailman School of Public Health, Columbia University, New York, NY, USA.
Kent D TaylorDavid Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA, USA.
Stephen S RichDepartment of Public Health Sciences, Center for Public Health Genomics, University of Virginia, Charlottesville, VA, USA.
Tobias N BontenDepartment of Public Health and Primary Care, Leiden University Medical Center, Leiden, The Netherlands.
Dennis O Mook-KanamoriDepartment of Clinical Epidemiology, Leiden University Medical Center, Leiden, The Netherlands.
Raymond NoordamDivision of Gerontology and Geriatrics, Department of Internal Medicine, Leiden University Medical Center, Leiden, The Netherlands.
Ruifang Li-GaoDepartment of Clinical Epidemiology, Leiden University Medical Center, Leiden, The Netherlands.
Marjo-Riitta JarvelinDepartment of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London, UK.
Matthias WielscherDepartment of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London, UK.
Natalie TerzikhanDepartment of Epidemiology, Erasmus University Medical Center, Rotterdam, The Netherlands.
Lies LahousseDepartment of Epidemiology, Erasmus University Medical Center, Rotterdam, The Netherlands.
Guy BrusselleDepartment of Epidemiology, Erasmus University Medical Center, Rotterdam, The Netherlands.
Stefan WeissInterfaculty Institute for Genetics and Functional Genomics, University Medicine Greifswald, Greifswald, Germany.
Ralf EwertDivision of Cardiology, Pneumology, Infectious Diseases, Intensive Care Medicine, Department of Internal Medicine B, University Medicine Greifswald, Greifswald, Germany.
Sven GläserDivision of Cardiology, Pneumology, Infectious Diseases, Intensive Care Medicine, Department of Internal Medicine B, University Medicine Greifswald, Greifswald, Germany.
Georg HomuthInterfaculty Institute for Genetics and Functional Genomics, University Medicine Greifswald, Greifswald, Germany.
Nick ShrineDepartment of Health Sciences, University of Leicester, Leicester, UK.
Ian P HallDivision of Respiratory Medicine, University of Nottingham, Nottingham, UK.
Martin TobinDepartment of Health Sciences, University of Leicester, Leicester, UK.
Stephanie J LondonDepartment of Health and Human Services, Epidemiology Branch, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, NC, USA. london2@niehs.nih.gov.
Peng WeiDepartment of Biostatistics, The University of Texas MD Anderson Cancer Center, Houston, TX, USA. Pwei2@mdanderson.org.
Alanna C MorrisonHuman Genetics Center, Department of Epidemiology, Human Genetics and Environmental Sciences, School of Public Health, The University of Texas Health Science Center at Houston, Houston, TX, USA. Alanna.C.Morrison@uth.tmc.edu.
Leiden University Medical Center · NLHelmholtz Zentrum München · DEUniversitätsmedizin Greifswald · DEBoston University · USColumbia University · USDuke University · USErasmus MC · NLGerman Center for Lung Research · DEOffice of Public Health Genomics · USThe University of Texas Health Science Center at Houston · USUniversity of Edinburgh · GBUniversity of Leicester · GBUniversity of Washington · USAlzheimer Scotland · GBCornell University · USGhent University Hospital · BEIcahn School of Medicine at Mount Sinai · USImperial College London · GBKaiser Permanente Washington Health Research Institute · USNational Institute for Health Research · GB
Funding
UCLA Clinical Translational Science InstituteUL1TR001881 · NCATS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI ARLEEN F. BROWN, ARASH NAEIM · 2016 to 2026
$118.1MInstitute for Clinical and Translational ResearchUL1TR001079 · NCATS · JOHNS HOPKINS UNIVERSITY · PI FORD, DANIEL ERNEST · 2013 to 2017
$60.1MTransgenic & Knock-out MouseP30DK063491 · NIDDK · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI MILES Frome WILKINSON · 2003 to 2026
$40.4MWake Forest Clinical and Translational Science AwardUL1TR001420 · NCATS · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI ARD, JAMY D, FOLEY, KRISTIE L · 2015 to 2023
$32.3MFRAMINGHAM HEART STUDY - YEAR 5 EXAM75N92019D00031 · NHLBI · BOSTON UNIVERSITY MEDICAL CAMPUS · 2019 to 2024
$29.8MBuilding on GWAS for NHLBI-disease: the CHARGE consortiumRC2HL102419 · NHLBI · UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON · PI BOERWINKLE, ERIC A. · 2009 to 2010
$27.6MClinical and Translational Science AwardUL1TR000040 · NCATS · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI GINSBERG, HENRY N · 2012 to 2015
$26.2MPulmonary microvascular perfusion in the Multi-Ethnic Study of AtherosclerosisR01HL077612 · NHLBI · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI R Graham BARR · 2004 to 2026
$18.8MPulmonary Vascular Changes in Early Chronic Obstructive Pulmonary Disease (COPD)R01HL093081 · NHLBI · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI R Graham BARR · 2008 to 2026
$17.2MUCLA CLINICAL AND TRANSLATIONAL SCIENCE INSTITUTEUL1RR033176 · NCRR · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI DUBINETT, STEVEN M. · 2011 to 2011
$15.5MUtilizing the Phenomics of IBD to Enhance Gene DiscoveryU01DK062413 · NIDDK · CEDARS-SINAI MEDICAL CENTER · PI Dermot Patrick McGovern · 2002 to 2026
$12.2MMulti-Ethnic Study of Atherosclerosis (MESA) StudyR01HL071205 · NHLBI · CEDARS-SINAI MEDICAL CENTER · PI ROTTER, JEROME I · 2003 to 2007
$10.4MIntramural NIH HHS Z01 ES043012Medical Research Council G0700704Medical Research Council G1000861Medical Research Council MC_PC_17228Medical Research Council MC_QA137853Medical Research Council MR/K026992/1Medical Research Council MR/N011317/1NCATS NIH HHS UL1 TR000040NCATS NIH HHS UL1 TR001079NCATS NIH HHS UL1 TR001420NCATS NIH HHS UL1 TR001881NCRR NIH HHS UL1 RR033176NHGRI NIH HHS HHSN268200782096CNHLBI NIH HHS 75N92019D00031NHLBI NIH HHS HHSN268201500001CNHLBI NIH HHS HHSN268201500001INHLBI NIH HHS HHSN268201500003CNHLBI NIH HHS HHSN268201500003INHLBI NIH HHS HHSN268201700001CNHLBI NIH HHS HHSN268201700001INHLBI NIH HHS HHSN268201700002CNHLBI NIH HHS HHSN268201700002INHLBI NIH HHS HHSN268201700003CNHLBI NIH HHS HHSN268201700003INHLBI NIH HHS HHSN268201700004CNHLBI NIH HHS HHSN268201700004INHLBI NIH HHS HHSN268201700005CNHLBI NIH HHS HHSN268201700005INHLBI NIH HHS K23 HL130627NHLBI NIH HHS N01 HC025195NHLBI NIH HHS N01 HC095159NHLBI NIH HHS N01 HC095160NHLBI NIH HHS N01 HC095161NHLBI NIH HHS N01 HC095162NHLBI NIH HHS N01 HC095163NHLBI NIH HHS N01 HC095164NHLBI NIH HHS N01 HC095165NHLBI NIH HHS N01 HC095166NHLBI NIH HHS N01 HC095167NHLBI NIH HHS N01 HC095168NHLBI NIH HHS N01 HC095169NHLBI NIH HHS N02 HL064278NHLBI NIH HHS N02 HL64278NHLBI NIH HHS R01 HL071051NHLBI NIH HHS R01 HL071205NHLBI NIH HHS R01 HL071250NHLBI NIH HHS R01 HL071251NHLBI NIH HHS R01 HL071258NHLBI NIH HHS R01 HL071259NHLBI NIH HHS R01 HL077612NHLBI NIH HHS R01 HL093081NHLBI NIH HHS R01 HL105756NHLBI NIH HHS R01 HL131565NHLBI NIH HHS R21 HL126032NHLBI NIH HHS R21 HL129924NHLBI NIH HHS RC1 HL100543NHLBI NIH HHS RC2 HL102419NIA NIH HHS N01 AG062101NIA NIH HHS N01 AG062106NIA NIH HHS N01AG2103NIA NIH HHS R01 AG032098NIA NIH HHS RC1 AG035835NIDDK NIH HHS P30 DK063491NIDDK NIH HHS U01 DK062413Wellcome Trust 202849/Z/16/Z
Abstract
Genome-wide association studies have identified numerous common genetic variants associated with spirometric measures of pulmonary function, including forced expiratory volume in one second (FEV
Indexed as
Gene-Environment InteractionAdultAgedAged, 80 and overCigarette SmokingCyclic Nucleotide Phosphodiesterases, Type 3Datasets as TopicExonsFeasibility StudiesFemaleForced Expiratory VolumeGenome-Wide Association StudyHumansLungMaleMiddle AgedADGRG6 protein, humanCyclic Nucleotide Phosphodiesterases, Type 3PDE3B protein, humanReceptors, G-Protein-Coupled
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