ArticleNature communications2021
Zebrafish capable of generating future state prediction error show improved active avoidance behavior in virtual reality.
Article in Nature communications, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
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Who cites it
28 citing papers in PubMed.
- Closed-loop real-virtual interactions validate 3D model of social coordination in fish.PLoS computational biology · 2026Article
- Topographically organized dorsal raphe activity modulates forebrain sensory-motor representations and contributes to defensive behaviors.Nature communications · 2026Article
- Structured spontaneous activity through delta oscillation-based discrete states in the medaka telencephalon.Scientific reports · 2026Article
- The cerebellum implements structured representation of valence to support adaptive behavior control.Science advances · 2026Article
- Virtual social interaction reveals that the dorsal habenula-IPN pathway is essential for targeting the opponent.iScience · 2026Article
- How to Make Your Fish Work for You: Tips from Ethology and Ecology for Finding Appropriate Unconditioned Stimuli for Learning Studies withAnimals : an open access journal from MDPI · 2026Article
- When prediction fails: a computational complexity view of stress.Frontiers in veterinary science · 2026Article
- An open-source closed-loop Virtual Reality system to investigate social interactions and collective behavior in fish.PloS one · 2026Article
- Tachykinin 1-expressing neurons in the lateral habenula signal negative reward prediction error.bioRxiv : the preprint server for biology · 2025Article
- Evidence for Auditory Stimulus-Specific Adaptation But Not Deviance Detection in Larval Zebrafish Brains.The Journal of comparative neurology · 2025Article
- Devaluing memories of reward: a case for dopamine.Communications biology · 2025Article
- Whole-brain neural substrates of behavioral variability in the larval zebrafish.bioRxiv : the preprint server for biology · 2025Article
- A normative framework dissociates need and motivation in hypothalamic neurons.Science advances · 2024Article
- Adult zebrafish can learn Morris water maze-like tasks in a two-dimensional virtual reality system.Cell reports methods · 2024Article
- EVIDENCE FOR AUDITORY STIMULUS-SPECIFIC ADAPTATION BUT NOT DEVIANCE DETECTION IN LARVAL ZEBRAFISH BRAINS.bioRxiv : the preprint server for biology · 2024Article
- Predictive neural computations in the cerebellum contribute to motor planning and faster behavioral responses in larval zebrafish.Science advances · 2024Article
- Diving into the zebrafish brain: exploring neuroscience frontiers with genetic tools, imaging techniques, and behavioral insights.Frontiers in molecular neuroscience · 2024Review
- Experimental validation of the free-energy principle with in vitro neural networks.Nature communications · 2023Article
- Sensorimotor control of swimming Polypterus senegalus is preserved during sensory deprivation conditions across altered environments.The Journal of experimental biology · 2023Article
- An Overview of In Vitro Biological Neural Networks for Robot Intelligence.Cyborg and bionic systems (Washington, D.C.) · 2023Review
Corrections and comments
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Authors and funding
9 authors.
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No grant is acknowledged in the PubMed record.
Abstract
Animals make decisions under the principle of reward value maximization and surprise minimization. It is still unclear how these principles are represented in the brain and are reflected in behavior. We addressed this question using a closed-loop virtual reality system to train adult zebrafish for active avoidance. Analysis of the neural activity of the dorsal pallium during training revealed neural ensembles assigning rules to the colors of the surrounding walls. Additionally, one third of fish generated another ensemble that becomes activated only when the real perceived scenery shows discrepancy from the predicted favorable scenery. The fish with the latter ensemble escape more efficiently than the fish with the former ensembles alone, even though both fish have successfully learned to escape, consistent with the hypothesis that the latter ensemble guides zebrafish to take action to minimize this prediction error. Our results suggest that zebrafish can use both principles of goal-directed behavior, but with different behavioral consequences depending on the repertoire of the adopted principles.
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