Evidence map›Paper›PMID 34588418›Full record

ArticleSignal transduction and targeted therapy2021

High-throughput screening and evaluation of repurposed drugs targeting the SARS-CoV-2 main protease.

Yan Li, Jinyong Zhang, Zilei Duan, Ning Wang, Xiangcheng Sun, Yanjing Zhang, Li Fu, Kaiyun Liu, Yongjun Yang, Shulei Pan and 5 more

Open access · goldAbstract readLetterComment
In one paragraph

Article in Signal transduction and targeted therapy, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.6field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 8 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Article
  5. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

15 authors at 3 institutions in 1 country.

Yan Li *West China Biopharm Research Institute, West China Hospital, Sichuan University, Chengdu, Sichuan, 610041, China.
Jinyong Zhang *National Engineering Research Center of Immunological Products, Department of Microbiology and Biochemical Pharmacy, College of Pharmacy, Army Medical University, Chongqing, 400038, China.
Zilei Duan *Key Laboratory of Animal Models and Human Disease Mechanisms of Chinese Academy of Sciences/Key Laboratory of Bioactive Peptides of Yunnan Province, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, Yunnan, 650223, China.
Ning WangWest China Biopharm Research Institute, West China Hospital, Sichuan University, Chengdu, Sichuan, 610041, China.
Xiangcheng SunWest China Biopharm Research Institute, West China Hospital, Sichuan University, Chengdu, Sichuan, 610041, China.ORCID 0000-0003-1943-4979
Yanjing ZhangThe Research Core Facility, West China Hospital, Sichuan University, Chengdu, Sichuan, 610041, China.
Li FuThe Research Core Facility, West China Hospital, Sichuan University, Chengdu, Sichuan, 610041, China.
Kaiyun LiuWest China Biopharm Research Institute, West China Hospital, Sichuan University, Chengdu, Sichuan, 610041, China.
Yongjun YangMedical Research Center, Southwest Hospital, Army Medical University, Chongqing, 400038, China.
Shulei PanWest China Biopharm Research Institute, West China Hospital, Sichuan University, Chengdu, Sichuan, 610041, China.
Yun ShiWest China Biopharm Research Institute, West China Hospital, Sichuan University, Chengdu, Sichuan, 610041, China.
Hao ZengNational Engineering Research Center of Immunological Products, Department of Microbiology and Biochemical Pharmacy, College of Pharmacy, Army Medical University, Chongqing, 400038, China.
Gang GuoWest China Biopharm Research Institute, West China Hospital, Sichuan University, Chengdu, Sichuan, 610041, China. guogang7001@163.com.
Ren LaiKey Laboratory of Animal Models and Human Disease Mechanisms of Chinese Academy of Sciences/Key Laboratory of Bioactive Peptides of Yunnan Province, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, Yunnan, 650223, China. rlai@mail.kiz.ac.cn.
Quanming ZouNational Engineering Research Center of Immunological Products, Department of Microbiology and Biochemical Pharmacy, College of Pharmacy, Army Medical University, Chongqing, 400038, China. qmzou2007@163.com.
Sichuan University · CNArmy Medical University · CNKunming Institute of Zoology · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

COVID-19Pharmaceutical PreparationsHigh-Throughput Screening AssaysHumansPeptide HydrolasesSARS-CoV-2Peptide HydrolasesPharmaceutical Preparations

Identifiers

PMID34588418
PMCPMC8479016
OpenAlexW3203960425

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.