Evidence map›Paper›PMID 34588306›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2021

Killing of Gram-negative and Gram-positive bacteria by a bifunctional cell wall-targeting T6SS effector.

Nguyen-Hung Le, Victor Pinedo, Juvenal Lopez, Felipe Cava, Mario F Feldman

Abstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 68 papers.

0numbers the graph read from it
0cells of the map it votes in
68citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

68 citing papers in PubMed.

  1. Review
  2. Article
  3. Review
  4. Article
  5. Article
  6. Article
  7. Review
  8. Reprogrammed SimCells for antimicrobial therapy.Proceedings of the National Academy of Sciences of the United States of America · 2026
    Article
  9. Review
  10. Article
  11. Review
  12. Article
  13. Dissecting the antibacterial functions of the T6SS-2 cluster inApplied and environmental microbiology · 2025
    Article
  14. CommensalGut · 2025
    Article
  15. Antimicrobial agents and chemotherapy · 2025
    Review
  16. Article
  17. Article
  18. Two cysteines control Tse1 secretion by H1-T6SS in Pseudomonas aeruginosa.Protein science : a publication of the Protein Society · 2025
    Article
  19. Article
  20. Article

8 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Nguyen-Hung LeDepartment of Molecular Microbiology, Washington University in St. Louis School of Medicine, St. Louis, MO 63110.ORCID 0000-0001-8659-6949
Victor PinedoLaboratory for Molecular Infection Medicine Sweden, Department of Molecular Biology, Umeå Centre for Microbial Research, Umeå University, 90187 Umeå, Sweden.ORCID 0000-0002-9727-5224
Juvenal LopezDepartment of Molecular Microbiology, Washington University in St. Louis School of Medicine, St. Louis, MO 63110.ORCID 0000-0002-3433-2412
Felipe CavaLaboratory for Molecular Infection Medicine Sweden, Department of Molecular Biology, Umeå Centre for Microbial Research, Umeå University, 90187 Umeå, Sweden.ORCID 0000-0001-5995-718X
Mario F FeldmanDepartment of Molecular Microbiology, Washington University in St. Louis School of Medicine, St. Louis, MO 63110; mariofeldman@wustl.edu.

Funding

INVESTIGATING TYPE VI SECRETION IN ACINETOBACTER BAUMANNII AND ITS INTERPLAY WITH ANTIBIOTIC RESISTAR01AI125363 · NIAID · WASHINGTON UNIVERSITY · PI FELDMAN, MARIO · 2016 to 2020
$1.9M
PEPTIDOGLYCAN MODIFICATION AS AN IMMUNITY MECHANISM AGAINST TYPE 6 SECRETION ATTACK IN ACINETOBACTERR21AI137188 · NIAID · WASHINGTON UNIVERSITY · PI FELDMAN, MARIO · 2018 to 2019
$419k
NIAID NIH HHS R01 AI125363NIAID NIH HHS R21 AI137188
6 · The paper itself

Abstract

The type VI secretion system (T6SS) is a powerful tool deployed by Gram-negative bacteria to antagonize neighboring organisms. Here, we report that

Indexed as

Bacterial ProteinsBiological TransportCell WallGram-Negative BacteriaGram-Positive BacteriaType VI Secretion SystemsBacterial ProteinsType VI Secretion SystemseffectormicroenvironmentpeptidoglycanT6SS

Identifiers

PMID34588306
PMCPMC8501793

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.