ArticleProceedings of the National Academy of Sciences of the United States of America2021
Metabolism modulates network synchrony in the aging brain.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 1 of them a synthesis that pooled it.
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Who cites it
23 citing papers in PubMed, 1 synthesis or guideline pooled it, 26 citations in OpenAlex.
- Pooled it
- A generalized scaling law reveals synchrony-driven reorganization of brain dynamics across human lifespan.PLoS computational biology · 2026Article
- Novel insights into relationships between metabolic covariance patterns of FDG-PET data and clinical status in Parkinson's disease using partial least squares correlation analysis.Journal of Parkinson's disease · 2026Article
- Age-related changes to brain energetics revealed by PET/MRI imaging.NeuroImage. Clinical · 2026Article
- Spatially convergent functional MRI signatures of diabetes and male sex identify genetic vulnerabilities to accelerated brain ageing.Brain communications · 2026Article
- The metabolic engine of cognition: microglia-neuron interactions in health, ageing and disease.Nature metabolism · 2025Review
- A dose-finding study shows terazosin enhanced energy metabolism in neurologically healthy adults.Journal of Parkinson's disease · 2025Article
- The role of structural connectivity on brain function through a Markov model of signal transmission.bioRxiv : the preprint server for biology · 2025Article
- Brain aging shows nonlinear transitions, suggesting a midlife "critical window" for metabolic intervention.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Hidden high-risk states identification from routine urban traffic.PNAS nexus · 2025Article
- The role of structural connectivity on brain function through a Markov model of signal transmission.PloS one · 2025Article
- Constructing A Theoretical Model to Bridge Neural Transition with a State Switch in Bipolar Disorder.Neuroscience bulletin · 2025Article
- Article
- Brain Metabolism in Health and Neurodegeneration: The Interplay Among Neurons and Astrocytes.Cells · 2024Review
- A novel PDHK inhibitor restored cognitive dysfunction and limited neurodegeneration without affecting amyloid pathology in 5xFAD mouse, a model of Alzheimer's disease.Alzheimer's research & therapy · 2024Article
- Article
- Brain signaling becomes less integrated and more segregated with age.bioRxiv : the preprint server for biology · 2024Article
- D-ꞵ-hydroxybutyrate stabilizes hippocampal CA3-CA1 circuit during acute insulin resistance.PNAS nexus · 2024Article
- Interpretable prediction of brain activity during conversations from multimodal behavioral signals.PloS one · 2024Article
- Brain signaling becomes less integrated and more segregated with age.Network neuroscience (Cambridge, Mass.) · 2024Article
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
Abstract
Brain aging is associated with hypometabolism and global changes in functional connectivity. Using functional MRI (fMRI), we show that network synchrony, a collective property of brain activity, decreases with age. Applying quantitative methods from statistical physics, we provide a generative (Ising) model for these changes as a function of the average communication strength between brain regions. We find that older brains are closer to a critical point of this communication strength, in which even small changes in metabolism lead to abrupt changes in network synchrony. Finally, by experimentally modulating metabolic activity in younger adults, we show how metabolism alone-independent of other changes associated with aging-can provide a plausible candidate mechanism for marked reorganization of brain network topology.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.