Evidence map›Paper›PMID 34588198›Full record

Trial reportThe European respiratory journal2022

Violence-related distress and lung function in two longitudinal studies of youth.

Kristina Gaietto, Yueh-Ying Han, Erick Forno, Leonard B Bacharier, Wanda Phipatanakul, Theresa W Guilbert, Michael D Cabana, Kristie Ross, Joshua Blatter, Edna Acosta-Pérez and 7 more

Open access · bronzeAbstract readRandomized Controlled Trial
In one paragraph

Trial report in The European respiratory journal, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed, 2 pooled it
3.5field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 2 syntheses or guidelines pooled it, 17 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Review
  4. Observational
  5. Asthma: Biomedical and Psychobiological Perspectives.Biopsychosocial science and medicine · 2025
    Review
  6. Review
  7. The effects of violence and related stress on asthma.Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology · 2024
    Review
  8. Article
  9. Socioeconomic status, diet, and recurrent severe asthma exacerbations in Puerto Rican youth.The journal of allergy and clinical immunology. Global · 2024
    Article
  10. Article
  11. Article
  12. Article
  13. Child maltreatment and asthma.Pediatric pulmonology · 2022
    Review
  14. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors at 10 institutions in 2 countries.

Kristina GaiettoDivision of Pulmonary Medicine, Dept of Pediatrics, UPMC Children's Hospital of Pittsburgh, University of Pittsburgh, Pittsburgh, PA, USA.
Yueh-Ying HanDivision of Pulmonary Medicine, Dept of Pediatrics, UPMC Children's Hospital of Pittsburgh, University of Pittsburgh, Pittsburgh, PA, USA.ORCID 0000-0002-8409-3077
Erick FornoDivision of Pulmonary Medicine, Dept of Pediatrics, UPMC Children's Hospital of Pittsburgh, University of Pittsburgh, Pittsburgh, PA, USA.ORCID 0000-0001-6497-9885
Leonard B BacharierDivision of Allergy, Immunology, and Pulmonary Medicine, Dept of Pediatrics, Monroe Carell Jr Children's Hospital at Vanderbilt, Nashville, TN, USA.
Wanda PhipatanakulDivision of Allergy and Immunology, Dept of Pediatrics, Boston Children's Hospital, Harvard Medical School, Boston, MA, USA.
Theresa W GuilbertDivision of Pulmonary Medicine, Dept of Pediatrics, Cincinnati Children's Hospital, University of Cincinnati College of Medicine, Cincinnati, OH, USA.
Michael D CabanaDept of Pediatrics, Albert Einstein College of Medicine, Bronx, NY, USA.
Kristie RossDivision of Pediatric Pulmonology, UH Rainbow Babies and Children's Hospital, Case Western Reserve University, Cleveland, OH, USA.
Joshua BlatterDivision of Allergy, Immunology, and Pulmonary Medicine, Dept of Pediatrics, St Louis Children's Hospital, Washington University at St Louis, St Louis, MO, USA.
Edna Acosta-PérezBehavioral Sciences Research Institute, University of Puerto Rico, San Juan, Puerto Rico.
Gregory E MillerDept of Psychology, Northwestern University, Evanston, IL, USA.
Rafael E de la HozDept of Environmental Medicine and Public Health, Icahn School of Medicine at Mount Sinai, New York, NY, USA.ORCID 0000-0002-8949-9279
Franziska J RosserDivision of Pulmonary Medicine, Dept of Pediatrics, UPMC Children's Hospital of Pittsburgh, University of Pittsburgh, Pittsburgh, PA, USA.
Sandy DurraniDivision of Pulmonary Medicine, Dept of Pediatrics, Cincinnati Children's Hospital, University of Cincinnati College of Medicine, Cincinnati, OH, USA.
Glorisa CaninoBehavioral Sciences Research Institute, University of Puerto Rico, San Juan, Puerto Rico.
Stephen R WisniewskiDept of Epidemiology, University of Pittsburgh, Pittsburgh, PA, USA.
Juan C CeledónDivision of Pulmonary Medicine, Dept of Pediatrics, UPMC Children's Hospital of Pittsburgh, University of Pittsburgh, Pittsburgh, PA, USA juan.celedon@chp.edu.ORCID 0000-0002-6139-5320
University of Pittsburgh · USCincinnati Children's Hospital Medical Center · USUniversity of Puerto Rico System · PRAlbert Einstein College of Medicine · USBoston Children's Hospital · USIcahn School of Medicine at Mount Sinai · USMonroe Carell Jr. Children's Hospital · USNorthwestern University · USRainbow Babies & Children's Hospital · USSt. Louis Children's Hospital · US

Funding

University of Pittsburgh Clinical and Translational Science InstituteUL1TR001857 · NCATS · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI REIS, STEVEN E · 2016 to 2025
$129.3M
Institutional Career Development CoreKL2TR001856 · NCATS · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI RAY, KRISTIN N, RUBIO, DORIS M · 2016 to 2025
$13.8M
Epigenetic Variation and Childhood Asthma in Puerto RicansR01HL117191 · NHLBI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI CELEDON, JUAN CARLOS · 2013 to 2020
$5.8M
Genes, Home Allergens and Asthma Puerto Rican ChildrenR01HL079966 · NHLBI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI CELEDON, JUAN CARLOS · 2006 to 2010
$3.8M
Vitamin D to Prevent Severe Asthma Exacerbations in High-Risk Children - CCCU01HL119952 · NHLBI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI CELEDON, JUAN CARLOS · 2015 to 2018
$2.9M
Pittsburgh Training Grant in Pediatric Pulmonary MedicineT32HL129949 · NHLBI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI Juan Carlos Celedon · 2016 to 2026
$2.9M
Exposure to violence, epigenetic variation, and asthma in Puerto Rican childrenR01MD011764 · NIMHD · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI CELEDON, JUAN CARLOS · 2017 to 2020
$1.3M
NCATS NIH HHS KL2 TR001856NCATS NIH HHS UL1 TR001857NHLBI NIH HHS R01 HL079966NHLBI NIH HHS R01 HL117191NHLBI NIH HHS T32 HL129949NHLBI NIH HHS U01 HL119952NIMHD NIH HHS R01 MD011764
6 · The paper itself

Abstract

backgroundExposure to violence has been associated with lower lung function in cross-sectional studies.

methodsWe examined whether increasing violence-related distress over time is associated with worse lung function and worse asthma control or quality of life in a secondary analysis of a 48-week randomised clinical trial in 98 youth with asthma (aged 9-16 years) treated with low-dose inhaled corticosteroids (Vitamin D Kids Asthma Study (VDKA)). We then replicated our findings for lung function in a prospective study of 232 Puerto Rican youth followed for an average of 5.4 years. Violence-related distress was assessed using the Checklist of Children's Distress Symptoms (CCDS) scale. Our outcomes of interest were percent predicted lung function measures and (in VDKA only) asthma control (assessed using the Asthma Control Test) and asthma-related quality of life (assessed using the Pediatric Asthma Quality of Life Questionnaire (PAQLQ)).

resultsIn a multivariable analysis in VDKA, each 1-point increment in CCDS score was associated with decrements of 3.27% in forced expiratory volume in 1 s (FEV

conclusionsOur findings suggest that violence-related distress may worsen lung function and quality of life in youth with asthma (even those treated with low-dose inhaled corticosteroids), and further support policies to reduce exposure to violence among children in the USA and Puerto Rico.

Indexed as

AsthmaQuality of LifeAdolescentAdrenal Cortex HormonesChildCross-Sectional StudiesForced Expiratory VolumeHumansLongitudinal StudiesLungProspective StudiesViolenceVitamin DAdrenal Cortex HormonesVitamin D

Identifiers

PMID34588198
PMCPMC8960476
OpenAlexW3202322185

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.