ArticleThe European respiratory journal2022
Association of early-life factors with prematurity-associated lung disease: prospective cohort study.
Article in The European respiratory journal, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
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Who cites it
28 citing papers in PubMed, 45 citations in OpenAlex.
- Modulation of pulmonary desmosomes by inhaler therapy in preterm-born children with bronchopulmonary dysplasia.Scientific reports · 2023Trial
- Anakinra in a Preterm Infant with Bronchopulmonary Dysplasia: A Case Report.Children (Basel, Switzerland) · 2026Article
- Respiratory Sequelae of Prematurity in School-Age Children: Is Bronchopulmonary Dysplasia Still the Primary Risk Factor?Children (Basel, Switzerland) · 2025Article
- Caffeine Protects Against Hyperoxia-Induced Structural Lung Injury and Restores Alveolar Development in Neonatal Rats.Antioxidants (Basel, Switzerland) · 2025Article
- Current and Emerging Therapies for Prevention and Treatment of Bronchopulmonary Dysplasia in Preterm Infants.Paediatric drugs · 2025Review
- Lung function outcomes in adults born extremely preterm across three decades of advancing perinatal medicine.Acta paediatrica (Oslo, Norway : 1992) · 2025Article
- Moderate-to-late prematurity: understanding respiratory consequences and modifiable risk factors.European respiratory review : an official journal of the European Respiratory Society · 2025Review
- Prevalence and early-life risk factors of asthma in preterm adolescents: a cohort study.Frontiers in pediatrics · 2025Article
- Article
- Oligohydramnios affects pulmonary functional/structural abnormalities in school-aged children with bronchopulmonary dysplasia.Clinical and experimental pediatrics · 2024Article
- Evolving treatment for prematurity-associated lung disease.Translational pediatrics · 2024Article
- Early stress during NICU stay and parent-reported health-related quality of life after extremely preterm birth: an exploratory study with possible targets for early intervention.Frontiers in pediatrics · 2024Article
- Evidence of abnormality in glutathione metabolism in the airways of preterm born children with a history of bronchopulmonary dysplasia.Scientific reports · 2023Article
- Peripheral airway dysfunction in prematurity-associated obstructive lung disease identified by oscillometry.Pediatric pulmonology · 2023Article
- Characterising airway obstructive, dysanaptic and PRISm phenotypes of prematurity-associated lung disease.Thorax · 2023Article
- Characterizing the urinary proteome of prematurity-associated lung disease in school-aged children.Respiratory research · 2023Article
- ERS International Congress 2022: highlights from the Paediatrics Assembly.ERJ open research · 2023Review
- Increasing airway obstruction through life following bronchopulmonary dysplasia: a meta-analysis.ERJ open research · 2023Review
- Association of Gestation and Fetal Growth Restriction on Cardiovascular Health in Preterm-Born Children.The Journal of pediatrics · 2023Article
- ERS International Congress 2022: highlights from the Epidemiology and Environment Assembly.ERJ open research · 2023Article
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Authors and funding
6 authors at 3 institutions in 1 country.
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Abstract
backgroundAlthough bronchopulmonary dysplasia (BPD) is associated with lung function deficits in childhood, many who develop BPD have normal lung function in childhood and many without BPD, including those born at 33-34 weeks of gestation, have lung dysfunction in childhood. Since the predictability of BPD for future lung deficits is increasingly doubted, we prospectively recruited preterm-born children to identify early-life factors associated with lung function deficits after preterm birth.
methodsFrom 767 children aged 7-12 years who had their respiratory symptoms assessed, and had spirometry before and after a bronchodilator in our Respiratory Health Outcomes in Neonates (RHiNO) study, 739 (544 preterm-born at ≤34 weeks of gestation and 195 term-born) had satisfactory lung function. Data were analysed using multivariable logistic regression and mediation.
resultsWhen preterm-born children were classified according to their lung function, low lung function (prematurity-associated lung disease (PLD)) was associated with BPD, gestation and intra-uterine growth restriction (IUGR) on univariable logistic regression analyses. However, on multivariable logistic regression analyses, gestation (β= -0.153, se 0.051; p=0.003) and IUGR (OR 1.783, 95% CI 1.06-3.00; p=0.029) remained significantly associated with later deficits of lung function, but BPD (OR 0.99, 95% CI 0.52-1.89; p=0.974) did not. Mediation analyses confirmed these results.
conclusionsAlthough traditionally BPD has been associated with low lung function in later life, the data show that gestation and IUGR are significantly associated with PLD in childhood, but BPD is not. By identifying children with PLD, we can better understand the underlying mechanisms and develop optimal therapies.
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