Evidence map›Paper›PMID 34588178›Full record

ArticleClinical journal of the American Society of Nephrology : CJASN2021

COVID-19-Associated Mortality among Kidney Transplant Recipients and Candidates in the United States.

Sumit Mohan, Kristen L King, S Ali Husain, Jesse D Schold

Abstract read
In one paragraph

Article in Clinical journal of the American Society of Nephrology : CJASN, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.

0numbers the graph read from it
0cells of the map it votes in
30citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

30 citing papers in PubMed.

  1. Article
  2. Article
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  5. Article
  6. Long-term interplay between COVID-19 and chronic kidney disease.International urology and nephrology · 2023
    Review
  7. Observational
  8. Article
  9. Article
  10. Article
  11. Article
  12. Review
  13. COVID-associated pulmonary aspergillosis and herpes simplex virus pneumonia in a renal transplant recipient.Transplant infectious disease : an official journal of the Transplantation Society · 2022
    Article
  14. Review
  15. Article
  16. Article
  17. Review
  18. Review
  19. Heterologous Ad.26.COV2.S versus homologous BNT162b2/mRNA-1273 as a third dose in solid organ transplant recipients seronegative after two-dose mRNA vaccination.American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons · 2022
    Article
  20. Utilization and outcomes of deceased donor SARS-CoV-2-positive organs for solid organ transplantation in the United States.American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons · 2022
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Sumit MohanDivision of Nephrology, Department of Medicine, Vagelos College of Physicians and Surgeons, Columbia University, New York, New York.ORCID 0000-0002-5305-9685
Kristen L KingDivision of Nephrology, Department of Medicine, Vagelos College of Physicians and Surgeons, Columbia University, New York, New York.ORCID 0000-0002-7920-7615
S Ali HusainDivision of Nephrology, Department of Medicine, Vagelos College of Physicians and Surgeons, Columbia University, New York, New York.ORCID 0000-0002-1823-0117
Jesse D ScholdDepartment of Quantitative Health Sciences, Cleveland Clinic, Cleveland, Ohio.

Funding

Institutional Career Development CoreKL2TR001874 · NCATS · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI GENKINGER, JEANINE M., SHIMBO, DAICHI · 2016 to 2025
$13.6M
Continuous Therapeutic Drug Monitoring of Antibiotics in CRRTR01DK126739 · NIDDK · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI MOHAN, SUMIT · 2021 to 2024
$2.8M
India - Factors of CKDu in Uddanam Study (India-FOCUS)U01DK130058 · NIDDK · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI Vivekanand Jha, Sumit Mohan · 2021 to 2026
$2.6M
5/14 APOL1 Long-term Kidney Transplantation Outcomes Network (APOLLO) Clinical CenterU01DK116066 · NIDDK · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI Sumit Mohan, Deirdre Sawinski · 2017 to 2026
$2.5M
Identifying and exploring solutions to the ethical challenges of ApoL1 testing of donors with recent African ancestry through mixed methods research with stakeholdersR01MD014161 · NIMHD · WASHINGTON UNIVERSITY · PI DUBOIS, JAMES M, MOHAN, SUMIT · 2019 to 2021
$1.2M
Increasing Minority Population Awareness through Community Teaching for Improved Organ Donation (IMPACT for Improved Organ Donation)R01DK114893 · NIDDK · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI MOHAN, SUMIT · 2017 to 2021
$1.2M
NCATS NIH HHS KL2 TR001874NIDDK NIH HHS R01 DK114893NIDDK NIH HHS R01 DK126739NIDDK NIH HHS U01 DK116066NIDDK NIH HHS U01 DK130058NIMHD NIH HHS R01 MD014161
6 · The paper itself

Abstract

BACKGROUND AND

objectivesThe coronavirus disease 2019 (COVID-19) pandemic has had a profound effect on transplantation activity in the United States and globally. Several single-center reports suggest higher morbidity and mortality among candidates waitlisted for a kidney transplant and recipients of a kidney transplant. We aim to describe 2020 mortality patterns during the COVID-19 pandemic in the United States among kidney transplant candidates and recipients. DESIGN, SETTING, PARTICIPANTS, & MEASUREMENTS: Using national registry data for waitlisted candidates and kidney transplant recipients collected through April 23, 2021, we report demographic and clinical factors associated with COVID-19-related mortality in 2020, other deaths in 2020, and deaths in 2019 among waitlisted candidates and transplant recipients. We quantify excess all-cause deaths among candidate and recipient populations in 2020 and deaths directly attributed to COVID-19 in relation to prepandemic mortality patterns in 2019 and 2018.

resultsAmong deaths of patients who were waitlisted in 2020, 11% were attributed to COVID-19, and these candidates were more likely to be male, obese, and belong to a racial/ethnic minority group. Nearly one in six deaths (16%) among active transplant recipients in the United States in 2020 was attributed to COVID-19. Recipients who died of COVID-19 were younger, more likely to be obese, had lower educational attainment, and were more likely to belong to racial/ethnic minority groups than those who died of other causes in 2020 or 2019. We found higher overall mortality in 2020 among waitlisted candidates (24%) than among kidney transplant recipients (20%) compared with 2019.

conclusionsOur analysis demonstrates higher rates of mortality associated with COVID-19 among waitlisted candidates and kidney transplant recipients in the United States in 2020.

Indexed as

Transplant RecipientsAgedCause of DeathCOVID-19FemaleHumansKidney TransplantationMaleMiddle AgedRegistriesRisk AssessmentRisk FactorsTime FactorsTreatment OutcomeUnited StatesWaiting ListsCOVID-19kidney transplantationmortalityUnited States

Identifiers

PMID34588178
PMCPMC8729425

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.