Evidence map›Paper›PMID 34588095›Full record

ReviewComparative medicine2021

Hamsters as a Model of Severe Acute Respiratory Syndrome Coronavirus-2.

Alicia M Braxton, Patrick S Creisher, Camilo A Ruiz-Bedoya, Katie R Mulka, Santosh Dhakal, Alvaro A Ordonez, Sarah E Beck, Sanjay K Jain, Jason S Villano

Open access · greenAbstract readReview
In one paragraph

Review in Comparative medicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
1.2field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 22 citations in OpenAlex.

  1. Article
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  5. Article
  6. Article
  7. Review
  8. Article
  9. Article
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  11. Article
  12. Article
  13. Article
  14. Animal models for COVID-19: advances, gaps and perspectives.Signal transduction and targeted therapy · 2022
    Review
  15. Article
  16. COVID-19 and Animal-Based Research.Comparative medicine · 2021
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Alicia M BraxtonDepartment of Molecular and Comparative Pathobiology, Johns Hopkins University School of Medicine, Baltimore, Maryland; Department of Pathology, Sol Goldman Pancreatic Cancer Research Center, Johns Hopkins University School of Medicine, Baltimore, Maryland.
Patrick S CreisherDepartment of Molecular Microbiology and Immunology, Johns Hopkins University School of Public Health, Baltimore, Maryland.
Camilo A Ruiz-BedoyaDivision of Pediatric Infectious Diseases, Johns Hopkins University School of Medicine, Baltimore, Maryland.
Katie R MulkaDepartment of Molecular and Comparative Pathobiology, Johns Hopkins University School of Medicine, Baltimore, Maryland.
Santosh DhakalDepartment of Molecular Microbiology and Immunology, Johns Hopkins University School of Public Health, Baltimore, Maryland.
Alvaro A OrdonezDivision of Pediatric Infectious Diseases, Johns Hopkins University School of Medicine, Baltimore, Maryland.
Sarah E BeckDepartment of Molecular and Comparative Pathobiology, Johns Hopkins University School of Medicine, Baltimore, Maryland.
Sanjay K JainDivision of Pediatric Infectious Diseases, Johns Hopkins University School of Medicine, Baltimore, Maryland.
Jason S VillanoDepartment of Molecular and Comparative Pathobiology, Johns Hopkins University School of Medicine, Baltimore, Maryland.
Johns Hopkins University · USJohns Hopkins Medicine · US

Funding

Training Veterinarians for Careers in Biomedical ResearchT32OD011089 · OD · JOHNS HOPKINS UNIVERSITY · PI JOSEPH L MANKOWSKI · 2012 to 2026
$6.7M
Preclinical modeling to study Tuberculous MeningitisR01AI145435 · NIAID · JOHNS HOPKINS UNIVERSITY · PI JAIN, SANJAY · 2020 to 2024
$4.0M
Measuring Intralesional Drug Exposures in Cavitary TB using Noninvasive In Vivo PET ImagingR01AI153349 · NIAID · JOHNS HOPKINS UNIVERSITY · PI JAIN, SANJAY · 2020 to 2024
$3.8M
ACE2-targeted PET radiotracers for investigating spatiotemporal distribution of SARS-CoV-2 organ injury and therapy response.R01AI161829 · NIAID · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI DESAI, TEJAL A., FLAVELL, ROBERT RICHARD · 2021 to 2023
$2.4M
NIAID NIH HHS R01 AI145435NIAID NIH HHS R01 AI153349NIAID NIH HHS R01 AI161829NIH HHS T32 OD011089
6 · The paper itself

Abstract

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the cause of coronavirus disease 2019 (COVID-19), rapidly spread across the world in late 2019, leading to a pandemic. While SARS-CoV-2 infections predominately affect the respiratory system, severe infections can lead to renal and cardiac injury and even death. Due to its highly transmissible nature and severe health implications, animal models of SARS-CoV-2 are critical to developing novel therapeutics and preventatives. Syrian hamsters (

Indexed as

COVID-19Disease Models, AnimalAnimalsCOVID-19 SerotherapyCricetinaeHumansImmunization, PassiveMesocricetus

Identifiers

PMID34588095
PMCPMC8594257
OpenAlexW3202867395

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.