Evidence map›Paper›PMID 34587988›Full record

ArticleBMC chemistry2021

Design, synthesis, and biological evaluation of symmetrical azine derivatives as novel tyrosinase inhibitors.

Somaye Karimian, Fatemeh Kazemi, Mahshid Attarroshan, Maryam Gholampour, Shiva Hemmati, Amirhossein Sakhteman, Yasaman Behzadipour, Maryam Kabiri, Aida Iraji, Mehdi Khoshneviszadeh

Open access · goldAbstract read
In one paragraph

Article in BMC chemistry, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
3.0field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 39 citations in OpenAlex.

  1. Article
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  5. Review
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  7. ACS omega · 2023
    Article
  8. Article
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  10. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 1 country.

Somaye KarimianDepartment of Medicinal Chemistry, School of Pharmacy, Shiraz University of Medical Sciences, Shiraz, Iran.
Fatemeh KazemiDepartment of Medicinal Chemistry, School of Pharmacy, Shiraz University of Medical Sciences, Shiraz, Iran.
Mahshid AttarroshanMedicinal and Natural Products Chemistry Research Center, Shiraz University of Medical Sciences, Shiraz, Iran.
Maryam GholampourPharmaceutical Sciences Research Center, Shiraz University of Medical Sciences, Shiraz, Iran.
Shiva HemmatiPharmaceutical Sciences Research Center, Shiraz University of Medical Sciences, Shiraz, Iran.
Amirhossein SakhtemanDepartment of Medicinal Chemistry, School of Pharmacy, Shiraz University of Medical Sciences, Shiraz, Iran.
Yasaman BehzadipourDepartment of Medicinal Chemistry, School of Pharmacy, Shiraz University of Medical Sciences, Shiraz, Iran.
Maryam KabiriDepartment of Medicinal Chemistry, School of Pharmacy, Shiraz University of Medical Sciences, Shiraz, Iran.
Aida IrajiStem Cells Technology Research Center, Shiraz University of Medical Sciences, Shiraz, Iran. iraji@sums.ac.ir.
Mehdi KhoshneviszadehDepartment of Medicinal Chemistry, School of Pharmacy, Shiraz University of Medical Sciences, Shiraz, Iran. m.khoshneviszadeh@gmail.com.
Shiraz University of Medical Sciences · IRBiotechnology Research Center · IR

Funding

Vice-Chancellor for Research of Shiraz University of Medical Sciences 97-01-05-18440
6 · The paper itself

Abstract

A series of symmetrical azine derivatives containing different substituted benzyl moieties were designed, synthesized, and evaluated for their inhibitory activity against tyrosinase. The results showed that compounds 3e, 3f, 3h, 3i, 3j, and 3k possess effective tyrosinase inhibition with IC

Indexed as

Azine derivativesMelaninMolecular dockingTyrosinase inhibitors

Identifiers

PMID34587988
PMCPMC8480273
OpenAlexW3202122898

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.