ArticleORL; journal for oto-rhino-laryngology and its related specialties2021
Treatment Modality and Second Primary Tumors of the Head and Neck.
Article in ORL; journal for oto-rhino-laryngology and its related specialties, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers, 1 of them a synthesis that pooled it.
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Who cites it
7 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Factors associated with the development of second primary tumours in head and neck cancer patients.European journal of cancer care · 2022Pooled it
- Adjuvant Reirradiation With Proton Therapy in Head and Neck Squamous Cell Carcinoma.Advances in radiation oncology · 2024Article
- Spindle Cell Carcinoma of Buccal Mucosa: An Unusual Presentation of Squamous Cell Carcinoma.Cureus · 2024Article
- Incidence of second primary cancers in oral and pharyngeal cancer patients using a large medical claims database in Japan.Journal of dental sciences · 2023Article
- Treatment outcomes of squamous cell carcinoma of the lip: A retrospective study.Oncology letters · 2023Article
- Mutagen sensitivity and risk of second cancer in younger adults with head and neck squamous cell cancer: 15-year results.Strahlentherapie und Onkologie : Organ der Deutschen Rontgengesellschaft ... [et al] · 2022Article
- Second Primary Lung Adenocarcinoma After Intensity-Modulated Radiotherapy for Nasopharyngeal Carcinoma.Frontiers in oncology · 2022Article
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5 authors.
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Abstract
introductionSecond primary tumors (SPTs) in head and neck cancer are thought to occur from premalignant lesions that are present at the time of the primary tumor diagnosis. The association of the modality used to treat the primary lesion with SPT occurrence is not clear.
objectiveThe aim of the study was to assess the incidence of SPTs in patients with head and neck malignancies, according to treatment modality.
methodsWe conducted a retrospective cohort study. All patients who were treated at Soroka Medical Center between 2000 and 2013 for a head and neck squamous cell carcinoma were assessed. Data analysis included tumor site of the primary and second primary and treatment modality of the primary tumor. In addition, demographics as well as habits were recorded as well.
resultsOf the 184 patients included in the cohort, SPT developed in 31 patients (17%) with a median time to diagnosis of 4.3 years. Smoking was reported in 74% of those with SPT and 78% of those without. The most common site for SPT was the lungs, with 13 cases, 42% of the total SPTs. Among patients who developed an SPT, for 12 of those with an index tumor in the oral cavity or oro-hypopharynx, 8 (67%) developed an SPT in the same location; for 18 of those with an index tumor in the larynx, 11 (61%) developed a SPT in the lungs and bronchi (p = 0.001). On multivariate analysis, the treatment modality used was not found to be associated with the occurrence of SPTs and the radiotherapy showed no protective or harmful effect (HR 0.64 p = 0.24).
conclusionTreatment modality used for head and neck cancer does not seem to be associated with the occurrence of SPTs.
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