Evidence map›Paper›PMID 34587068›Full record

ArticleIEEE transactions on visualization and computer graphics2022

ThreadStates: State-based Visual Analysis of Disease Progression.

Qianwen Wang, Tali Mazor, Theresa A Harbig, Ethan Cerami, Nils Gehlenborg

Abstract read
In one paragraph

Article in IEEE transactions on visualization and computer graphics, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. L-VISP: LSTM Visualization for Interpretable Symptom Prediction in Patient Cohorts.Computer graphics forum : journal of the European Association for Computer Graphics · 2026
    Article
  2. KnowNet: Guided Health Information Seeking from LLMs via Knowledge Graph IntegrationIEEE transactions on visualization and computer graphics · 2025
    Article
  3. Article
  4. TrialView: An AI-powered Visual Analytics System for Temporal Event Data in Clinical Trials.Proceedings of the ... Annual Hawaii International Conference on System Sciences. Annual Hawaii International Conference on System Sciences · 2024
    Article
  5. DASS Good: Explainable Data Mining of Spatial Cohort Data.Computer graphics forum : journal of the European Association for Computer Graphics · 2023
    Article
  6. DRAVA: Aligning Human Concepts with Machine Learning Latent Dimensions for the Visual Exploration of Small Multiples.Proceedings of the SIGCHI conference on human factors in computing systems. CHI Conference · 2023
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Qianwen Wang
Tali Mazor
Theresa A Harbig
Ethan Cerami
Nils Gehlenborg

Funding

Visualization of (Epi)Genomic Data for Discovery of Disease-Associated VariantsR00HG007583 · NHGRI · HARVARD MEDICAL SCHOOL · PI GEHLENBORG, NILS · 2015 to 2017
$727k
NHGRI NIH HHS R00 HG007583
6 · The paper itself

Abstract

A growing number of longitudinal cohort studies are generating data with extensive patient observations across multiple timepoints. Such data offers promising opportunities to better understand the progression of diseases. However, these observations are usually treated as general events in existing visual analysis tools. As a result, their capabilities in modeling disease progression are not fully utilized. To fill this gap, we designed and implemented ThreadStates, an interactive visual analytics tool for the exploration of longitudinal patient cohort data. The focus of ThreadStates is to identify the states of disease progression by learning from observation data in a human-in-the-loop manner. We propose a novel Glyph Matrix design and combine it with a scatter plot to enable seamless identification, observation, and refinement of states. The disease progression patterns are then revealed in terms of state transitions using Sankey-based visualizations. We employ sequence clustering techniques to find patient groups with distinctive progression patterns, and to reveal the association between disease progression and patient-level features. The design and development were driven by a requirement analysis and iteratively refined based on feedback from domain experts over the course of a 10-month design study. Case studies and expert interviews demonstrate that ThreadStates can successively summarize disease states, reveal disease progression, and compare patient groups.

Indexed as

Computer GraphicsCluster AnalysisData Interpretation, StatisticalDisease ProgressionHumansLongitudinal Studies

Identifiers

PMID34587068
PMCPMC13289322

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.