Evidence map›Paper›PMID 34586953›Full record

ArticleThe Journal of international medical research2021

DICER-AS1 functions as competing endogenous RNA that targets CSR1 by sponging microRNA-650 and suppresses gastric cancer progression.

Junyan An, Xiaoling Guo, Bingli Yan

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The Journal of international medical research, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.2field-weighted citation impact, top 56% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 2 citations in OpenAlex.

  1. Functions and mechanisms of miR-650 in human diseases.Frontiers in molecular biosciences · 2026
    Review
  2. Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Junyan AnDepartment of Gastroenterology, Weifang People's Hospital, China.
Xiaoling GuoInfectious Diseases Department, Weifang People's Hospital, China.
Bingli YanDepartment of Gastroenterology, Weifang People's Hospital, China.ORCID https://orcid.org/0000-0003-3224-6120
Weifang People's Hospital · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveThis study explored the functional interactions between the long non-coding RNA DICER-AS1 and the cellular stress response 1 (

methodsQuantitative polymerase chain reaction (qPCR) and western blotting were used to measure DICER-AS1, CSR1, and miR-650 expression levels. Gastric cancer cell line proliferation and migration abilities were analyzed using the MTT and transwell migration and invasion assays, respectively. Bioinformatic analysis and dual luciferase reporter assays were employed to study the functional interactions among miR-650, DICER-AS1, and

resultsDICER-AS1 and

conclusionsThese results suggest that DICER-AS1 functions as a competing endogenous RNA that regulates miR-650 to suppress proliferation and migration of gastric cancer cells by targeting

Indexed as

MicroRNAsStomach NeoplasmsCell Line, TumorCell MovementCell ProliferationDEAD-box RNA HelicasesGene Expression Regulation, NeoplasticHeat-Shock ProteinsHumansNeoplasm InvasivenessRibonuclease IIIScavenger Receptors, Class ADEAD-box RNA HelicasesDICER1 protein, humanHeat-Shock ProteinsMicroRNAsMIRN650 microRNA, humanRibonuclease IIISCARA3 protein, humanScavenger Receptors, Class Acellular stress response 1 geneDICER-AS1Gastric cancermigrationmiR-650proliferation

Identifiers

PMID34586953
PMCPMC8485291
OpenAlexW3204957950

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.