Evidence map›Paper›PMID 34586899›Full record

SynthesisThe British journal of radiology2021

The application of radiomics in laryngeal cancer.

Amarkumar Dhirajlal Rajgor, Shreena Patel, David McCulloch, Boguslaw Obara, Jaume Bacardit, Andrew McQueen, Eric Aboagye, Tamir Ali, James O'Hara, David Winston Hamilton

Abstract readSystematic Review
In one paragraph

Synthesis in The British journal of radiology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 2 syntheses or guidelines pooled it.

  1. The application of radiomics in vestibular schwannomas.The Journal of laryngology and otology · 2025
    Pooled it
  2. Pooled it
  3. Laryngeal Cancer Survival in Northern United Kingdom: A Multi-Centre Retrospective Observational Study.Clinical otolaryngology : official journal of ENT-UK ; official journal of Netherlands Society for Oto-Rhino-Laryngology & Cervico-Facial Surgery · 2026
    Observational
  4. Article
  5. Review
  6. Article
  7. Development and validation of anAnnals of nuclear medicine · 2025
    Article
  8. [Integrated imaging and clinical features of glottic squamous cell carcinoma of the larynx: pathological association and prognosis assessment].Lin chuang er bi yan hou tou jing wai ke za zhi = Journal of clinical otorhinolaryngology head and neck surgery · 2025
    Article
  9. Outcomes of the modern management approach for locally advanced (TThe Journal of laryngology and otology · 2024
    Article
  10. Article
  11. Article
  12. Review
  13. Article
  14. Exploring Radiomics for Classification of Supraglottic Tumors: A Pilot Study in a Tertiary Care Center.Indian journal of otolaryngology and head and neck surgery : official publication of the Association of Otolaryngologists of India · 2023
    Article
  15. Article
  16. Article
  17. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Amarkumar Dhirajlal RajgorOtolaryngology Department, Newcastle-Upon-Tyne Hospitals NHS Foundation Trust, Newcastle Upon Tyne, UK.ORCID 0000-0002-9323-3107
Shreena PatelEast of England NHS Foundation Trainee, Bedfordshire, UK.
David McCullochRadiology Department, Newcastle-Upon-Tyne Hospitals NHS Foundation Trust, Newcastle Upon Tyne, UK.
Boguslaw ObaraSchool of Computing, Newcastle University, Urban Sciences Building, Newcastle upon Tyne, UK.
Jaume BacarditSchool of Computing, Newcastle University, Urban Sciences Building, Newcastle upon Tyne, UK.
Andrew McQueenRadiology Department, Newcastle-Upon-Tyne Hospitals NHS Foundation Trust, Newcastle Upon Tyne, UK.
Eric AboagyeImperial College London Cancer Imaging Centre, Department of Surgery & Cancer, Hammersmith Hospital, London, UK.
Tamir AliRadiology Department, Newcastle-Upon-Tyne Hospitals NHS Foundation Trust, Newcastle Upon Tyne, UK.
James O'HaraOtolaryngology Department, Newcastle-Upon-Tyne Hospitals NHS Foundation Trust, Newcastle Upon Tyne, UK.
David Winston HamiltonOtolaryngology Department, Newcastle-Upon-Tyne Hospitals NHS Foundation Trust, Newcastle Upon Tyne, UK.

Funding

Medical Research Council MR/V037528/1
6 · The paper itself

Abstract

objectivesRadiomics is the conversion of medical images into quantitative high-dimensional data. Laryngeal cancer, one of the most common head and neck cancers, has risen globally by 58.7%. CT, MRI and PET are acquired during the diagnostic process providing potential data for radiomic analysis and correlation with outcomes.This review aims to examine the applications of this technique to laryngeal cancer and the future considerations for translation into clinical practice.

methodsA comprehensive systematic review-informed search of the MEDLINE and EMBASE databases was undertaken. Keywords "laryngeal cancer" OR "larynx" OR "larynx cancer" OR "head and neck cancer" were combined with "radiomic" OR "signature" OR "machine learning" OR "artificial intelligence". Additional articles were obtained from bibliographies using the "snowball method".

resultsThe included studies (

conclusionsRadiomics has potential for improving multiple aspects of laryngeal cancer care; however, the heterogeneous cohorts and lack of data on laryngeal cancer exclusively inhibits firm conclusions. Large prospective well-designed studies in laryngeal cancer are required to progress this field. Furthermore, to implement radiomics into clinical practice, a unified research effort is required to standardise radiomics practice. ADVANCES IN KNOWLEDGE: This review has highlighted the value of radiomics in enhancing laryngeal cancer care (including staging, prognosis and predicting treatment response).

Indexed as

HumansImage Interpretation, Computer-AssistedLaryngeal NeoplasmsLarynxMachine LearningMagnetic Resonance ImagingPositron-Emission TomographyTomography, X-Ray Computed

Identifiers

PMID34586899
PMCPMC8631034

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.