Evidence map›Paper›PMID 34586892›Full record

ArticleJournal of clinical microbiology2022

Improved Molecular Diagnosis and Culture of the Emerging Heteropathotype Enterohemorrhagic Escherichia coli O80:H2 Using Its Non-Melibiose-Fermenting and Antibiotic-Resistance Properties.

Etienne Bizot, Aurélie Cointe, Natacha Smadja, Delphine Sergentet, Sophie Lefèvre, François-Xavier Weill, Corinne Levy, Robert Cohen, Patricia Mariani-Kurkdjian, Stéphane Bonacorsi

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In one paragraph

Article in Journal of clinical microbiology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.6field-weighted citation impact, top 31% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 5 citations in OpenAlex.

  1. Emerging hybrid shigatoxigenic and enteropathogenicClinical microbiology reviews · 2025
    Review
  2. Article
  3. Article
  4. Microorganisms · 2023
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 5 institutions in 1 country.

Etienne Bizot *Université de Paris, IAME, UMR 1137, INSERM, Paris, France.
Aurélie Cointe *Université de Paris, IAME, UMR 1137, INSERM, Paris, France.
Natacha SmadjaService de Microbiologie, Centre National de Référence Escherichia coli, AP-HP, Hôpital Robert-Debré, Paris, France.
Delphine SergentetLaboratoire d'Étude des Microorganismes Pathogènes, French Laboratory for Shiga Toxin-Producing Escherichia coli, VetAgro Supgrid.434200.1, Campus vétérinaire, Marcy L'Etoile, France.
Sophie LefèvreInstitut Pasteurgrid.428999.7, Unité des Bactéries Pathogènes Entériques, Centre National de Référence des Escherichia coli, Shigella et Salmonella, Paris, France.
François-Xavier WeillInstitut Pasteurgrid.428999.7, Unité des Bactéries Pathogènes Entériques, Centre National de Référence des Escherichia coli, Shigella et Salmonella, Paris, France.
Corinne LevyAssociation Clinique Thérapeutique Infantile du Val de Marne (ACTIV), Saint Maur des Fossés, France.
Robert CohenAssociation Clinique Thérapeutique Infantile du Val de Marne (ACTIV), Saint Maur des Fossés, France.
Patricia Mariani-KurkdjianUniversité de Paris, IAME, UMR 1137, INSERM, Paris, France.
Stéphane BonacorsiUniversité de Paris, IAME, UMR 1137, INSERM, Paris, France.ORCID 0000-0001-6447-6874
Inserm · FRAssociation Clinique et Thérapeutique Infantile du Val de Marne · FRInstitut Pasteur · FRAssistance Publique – Hôpitaux de Paris · FRVetAgro Sup · FR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Enterohemorrhagic Escherichia coli (EHEC) O80:H2, belonging to sequence type ST301, is among the main causes of hemolytic and uremic syndrome in Europe, a major concern in young children. Aside from the usual intimin and Shiga toxin virulence factors (VFs), this emerging serotype possesses a mosaic plasmid combining extra-intestinal VF- and antibiotic resistance-encoding genes. This hybrid pathotype can be involved in invasive infections, a rare occurrence in EHEC infections. Here, we aimed to optimize its detection, improve its clinical diagnosis, and identify its currently unknown reservoir. O80:H2 EHEC strains isolated in France between 2010 and 2018 were phenotypically and genetically analyzed and compared with non-O80 strains. The specificity and sensitivity of a PCR test and a culture medium designed, based on the molecular and phenotypic signatures of O80:H2 EHEC, were assessed on a collection of strains and stool samples. O80:H2 biotype analysis showed that none of the strains (

Indexed as

Drug Resistance, BacterialEnterohemorrhagic Escherichia coliHemolytic-Uremic SyndromeAnti-Bacterial AgentsChildChild, PreschoolCulture MediaFermentationHumansMelibioseAnti-Bacterial AgentsCulture MediaMelibioseculture mediumdiagnostic toolsenterohemorrhagic Escherichia coliheteropathotypepatient managementPCRShiga toxin

Identifiers

PMID34586892
PMCPMC8769747
OpenAlexW3202304386

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.