Evidence map›Paper›PMID 34586866›Full record

ArticleJournal of virology2021

Genetic and Antigenic Characterization of an Influenza A(H3N2) Outbreak in Cambodia and the Greater Mekong Subregion during the COVID-19 Pandemic, 2020.

Jurre Y Siegers, Vijaykrishna Dhanasekaran, Ruopeng Xie, Yi-Mo Deng, Sarika Patel, Vanra Ieng, Jean Moselen, Heidi Peck, Ammar Aziz, Borann Sarr and 10 more

Open access · hybridAbstract read
In one paragraph

Article in Journal of virology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
4.2field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 27 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Article
  5. The re-emergence of influenza following the COVID-19 pandemic in Victoria, Australia, 2021 to 2022.Euro surveillance : bulletin Europeen sur les maladies transmissibles = European communicable disease bulletin · 2023
    Article
  6. Article
  7. Global patterns and drivers of influenza decline during the COVID-19 pandemic.International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases · 2023
    Article
  8. Article
  9. Review
  10. Article
  11. Article
  12. National FluWatch mid-season report, 2021-2022: Sporadic influenza activity returns.Canada communicable disease report = Releve des maladies transmissibles au Canada · 2022
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

20 authors at 5 institutions in 3 countries.

Jurre Y SiegersNational Influenza Center of Cambodia, Virology Unit, Institut Pasteur du Cambodgegrid.418537.c, Phnom Penh, Cambodia.
Vijaykrishna DhanasekaranSchool of Public Health, LKS Faculty of Medicine, The University of Hong Kong, Hong Kong, China.
Ruopeng XieSchool of Public Health, LKS Faculty of Medicine, The University of Hong Kong, Hong Kong, China.
Yi-Mo DengWorld Health Organization Collaborating Center, Victorian Infectious Diseases Reference Laboratory, Peter Doherty Institute for Infection and Immunity, Melbourne, Australia.
Sarika PatelWorld Health Organization Country Office, Phnom Penh, Cambodia.
Vanra IengWorld Health Organization Country Office, Phnom Penh, Cambodia.
Jean MoselenWorld Health Organization Collaborating Center, Victorian Infectious Diseases Reference Laboratory, Peter Doherty Institute for Infection and Immunity, Melbourne, Australia.
Heidi PeckWorld Health Organization Collaborating Center, Victorian Infectious Diseases Reference Laboratory, Peter Doherty Institute for Infection and Immunity, Melbourne, Australia.
Ammar AzizWorld Health Organization Collaborating Center, Victorian Infectious Diseases Reference Laboratory, Peter Doherty Institute for Infection and Immunity, Melbourne, Australia.
Borann SarrU.S. Centers for Disease Control and Preventiongrid.416738.f, Phnom Penh, Cambodia.
Savuth ChinNational Institute of Public Health, Ministry of Health, Phnom Penh, Cambodia.
Seng HengCenters for Disease Control and Preventiongrid.416738.f, Ministry of Health, Phnom Penh, Cambodia.
Asheena KhalakdinaWorld Health Organization Country Office, Phnom Penh, Cambodia.
Michael KinzerU.S. Centers for Disease Control and Preventiongrid.416738.f, Phnom Penh, Cambodia.
Darapheak ChauNational Institute of Public Health, Ministry of Health, Phnom Penh, Cambodia.
Philomena RafteryWorld Health Organization Country Office, Phnom Penh, Cambodia.
Veasna DuongNational Influenza Center of Cambodia, Virology Unit, Institut Pasteur du Cambodgegrid.418537.c, Phnom Penh, Cambodia.ORCID 0000-0003-0353-1678
Ly SovannCenters for Disease Control and Preventiongrid.416738.f, Ministry of Health, Phnom Penh, Cambodia.
Ian G Barr *World Health Organization Collaborating Center, Victorian Infectious Diseases Reference Laboratory, Peter Doherty Institute for Infection and Immunity, Melbourne, Australia.
Erik A Karlsson *National Influenza Center of Cambodia, Virology Unit, Institut Pasteur du Cambodgegrid.418537.c, Phnom Penh, Cambodia.ORCID 0000-0001-6004-5671
Victorian Infectious Diseases Reference Laboratory · AUMinistry of Health · KHInstitut Pasteur du Cambodge · KHCambodia National Malaria Center · KHHKU-Pasteur Research Pole · HK

Funding

NIAID Centers of Excellence for Influenza Research and Response: Universal Influenza Vaccine Research Activities75N93021C00016 · NIAID · ST. JUDE CHILDREN'S RESEARCH HOSPITAL · PI WEBBY, RICHARD · 2021 to 2025
$91.4M
NIAID NIH HHS 75N93021C00016NIAID NIH HHS HHSN272201400006CWorld Health Organization 001
6 · The paper itself

Abstract

Introduction of non-pharmaceutical interventions to control COVID-19 in early 2020 coincided with a global decrease in active influenza circulation. However, between July and November 2020, an influenza A(H3N2) epidemic occurred in Cambodia and in other neighboring countries in the Greater Mekong Subregion in Southeast Asia. We characterized the genetic and antigenic evolution of A(H3N2) in Cambodia and found that the 2020 epidemic comprised genetically and antigenically similar viruses of Clade3C2a1b/131K/94N, but they were distinct from the WHO recommended influenza A(H3N2) vaccine virus components for 2020-2021 Northern Hemisphere season. Phylogenetic analysis revealed multiple virus migration events between Cambodia and bordering countries, with Laos PDR and Vietnam also reporting similar A(H3N2) epidemics immediately following the Cambodia outbreak: however, there was limited circulation of these viruses elsewhere globally. In February 2021, a virus from the Cambodian outbreak was recommended by WHO as the prototype virus for inclusion in the 2021-2022 Northern Hemisphere influenza vaccine.

Indexed as

CambodiaCOVID-19Disease OutbreaksHumansInfluenza A Virus, H3N2 SubtypeInfluenza, HumanInfluenza VaccinesLaosLikelihood FunctionsPhylogenySARS-CoV-2VietnamInfluenza VaccinesA(H3N2)CambodiaCOVID-19influenzaInfluenzaLaosoutbreakvaccineVietnam

Identifiers

PMID34586866
PMCPMC8610588
OpenAlexW3203411757

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.