ArticleScience advances2021
G-CSF secreted by mutant IDH1 glioma stem cells abolishes myeloid cell immunosuppression and enhances the efficacy of immunotherapy.
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Article in Science advances, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 64 papers.
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64citing papers in PubMed
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Who cites it
64 citing papers in PubMed.
- Autophagy inhibition sensitizes radiotherapy responses in high-grade mutant IDH1 glioma.Nature communications · 2026Article
- A dual pronged approach to cancer immune exclusion: tumor-derived LAIR-1 simultaneously drives fibrosis and blocks immune recruitment in glioma.Research square · 2026Article
- Reprogramming the immune suppressive tumor microenvironment in glioma enhances the efficacy of immune-mediated gene therapy.Molecular therapy. Oncology · 2026Article
- IDH1-R132H enhances oncolytic HSV-1 therapy by facilitating viral entry and immune activation in glioma.Nature communications · 2026Article
- Murine modeling of IDH-mutant 1p/19q-codeleted oligodendroglioma reveals genotype specific phenotypes.bioRxiv : the preprint server for biology · 2026Article
- Article
- MIF-mediated reprogramming of myeloid lineage within the glioma tumor microenvironment impacts the efficacy of immune stimulatory gene therapy.bioRxiv : the preprint server for biology · 2026Article
- Positioning and reversible suppression of CCR7Immunity · 2026Article
- Metabolism of myeloid cells in brain tumors.Frontiers in immunology · 2026Review
- Single-cell profiling of peripheral and local immune compartments reveal unique genotype-independent prognostic immune signatures across isocitrate dehydrogenase-stratified glioma.Neuro-oncology · 2026Article
- Autophagy Upregulation in Mutant Isocitrate Dehydrogenase 1 (IDH1) Glioma Uncovers a Novel Therapeutic Target.Research square · 2025Article
- TCA cycle-derived oncometabolites in cancer and the immune microenvironment.Journal of biomedical science · 2025Review
- Advances in IDH-mutant glioma management: IDH inhibitors, clinical implications of INDIGO trial, and future perspectives.Future oncology (London, England) · 2025Review
- Article
- H3.3-G34R Mutation-Mediated Epigenetic Reprogramming Leads to Enhanced Efficacy of Immune Stimulatory Gene Therapy in Diffuse Hemispheric Gliomas.bioRxiv : the preprint server for biology · 2025Article
- Genetically Engineered and Implantable Mouse Brain Tumor Models: Characterization by Immunohistochemistry and Flow Cytometry.Current protocols · 2025Article
- (B)On(e)-cohistones and the epigenetic alterations at the root of bone cancer.Cell death and differentiation · 2025Review
- Epigenetic reprogramming in pediatric gliomas: from molecular mechanisms to therapeutic implications.Trends in cancer · 2024Review
- A strategy to design protein-based antagonists against type I cytokine receptors.PLoS biology · 2024Article
- Mutant IDH Modulates Suppressive Myeloid Populations in Malignant Glioma.Clinical cancer research : an official journal of the American Association for Cancer Research · 2024Article
4 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
29 authors.
Mahmoud S AlghamriDepartment of Neurosurgery, University of Michigan Medical School, Ann Arbor, MI 48109, USA.ORCID 0000-0002-8018-7674
Brandon L McClellanDepartment of Neurosurgery, University of Michigan Medical School, Ann Arbor, MI 48109, USA.ORCID 0000-0001-8505-3854
Ruthvik P AvvariDepartment of Neurosurgery, University of Michigan Medical School, Ann Arbor, MI 48109, USA.ORCID 0000-0001-8780-6573
Rohit ThallaDepartment of Neurosurgery, University of Michigan Medical School, Ann Arbor, MI 48109, USA.
Stephen CarneyDepartment of Neurosurgery, University of Michigan Medical School, Ann Arbor, MI 48109, USA.ORCID 0000-0001-7786-5158
Carson S HartlageDepartment of Neurosurgery, University of Michigan Medical School, Ann Arbor, MI 48109, USA.ORCID 0000-0001-7875-8215
Santiago HaaseDepartment of Neurosurgery, University of Michigan Medical School, Ann Arbor, MI 48109, USA.
Maria VentosaDepartment of Neurosurgery, University of Michigan Medical School, Ann Arbor, MI 48109, USA.
Ayman TaherDepartment of Neurosurgery, University of Michigan Medical School, Ann Arbor, MI 48109, USA.ORCID 0000-0001-5600-296X
Neha KamranDepartment of Neurosurgery, University of Michigan Medical School, Ann Arbor, MI 48109, USA.
Li ZhangDepartment of Neurosurgery, University of Michigan Medical School, Ann Arbor, MI 48109, USA.ORCID 0000-0002-2738-1494
Syed Mohd FaisalDepartment of Neurosurgery, University of Michigan Medical School, Ann Arbor, MI 48109, USA.ORCID 0000-0002-3968-7810
Felipe J NúñezDepartment of Neurosurgery, University of Michigan Medical School, Ann Arbor, MI 48109, USA.ORCID 0000-0002-4962-3642
María Belén Garcia-FabianiDepartment of Neurosurgery, University of Michigan Medical School, Ann Arbor, MI 48109, USA.ORCID 0000-0002-2824-4926
Wajd N Al-HolouDepartment of Neurosurgery, University of Michigan Medical School, Ann Arbor, MI 48109, USA.ORCID 0000-0001-8528-4855
Daniel OrringerDepartment of Neurosurgery, University of Michigan Medical School, Ann Arbor, MI 48109, USA.ORCID 0000-0001-6427-8376
Shawn Hervey-JumperDepartment of Neurosurgery, University of California San Francisco, San Francisco, CA 94143, USA.ORCID 0000-0003-4699-260X
Jason HethDepartment of Neurosurgery, University of Michigan Medical School, Ann Arbor, MI 48109, USA.ORCID 0000-0001-5463-4066
Parag G PatilDepartment of Neurosurgery, University of Michigan Medical School, Ann Arbor, MI 48109, USA.ORCID 0000-0002-2300-6136
Karen EddyDepartment of Neurosurgery, University of Michigan Medical School, Ann Arbor, MI 48109, USA.
Sofia D MerajverDepartment of Internal Medicine, University of Michigan Medical School, Ann Arbor, MI 48109, USA.ORCID 0000-0002-6823-7130
Peter J UlintzDepartment of Internal Medicine, University of Michigan Medical School, Ann Arbor, MI 48109, USA.ORCID 0000-0002-2037-8655
Joshua WelchDepartment of Computational Medicine and Bioinformatics, University of Michigan Medical School, Ann Arbor, MI 48109, USA.ORCID 0000-0002-5869-2391
Chao GaoDepartment of Computational Medicine and Bioinformatics, University of Michigan Medical School, Ann Arbor, MI 48109, USA.ORCID 0000-0002-9316-2185
Jialin LiuDepartment of Computational Medicine and Bioinformatics, University of Michigan Medical School, Ann Arbor, MI 48109, USA.ORCID 0000-0002-9984-7695
Gabriel NúñezDepartment of Pathology, University of Michigan Medical School, Ann Arbor, MI 48109, USA.ORCID 0000-0002-6529-2695
Dolores HambardzumyanDepartment of Oncological Sciences, The Tisch Cancer Institute, and Department of Neurosurgery, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.
Pedro R LowensteinDepartment of Neurosurgery, University of Michigan Medical School, Ann Arbor, MI 48109, USA.ORCID 0000-0002-8427-4409
Maria G CastroDepartment of Neurosurgery, University of Michigan Medical School, Ann Arbor, MI 48109, USA.ORCID 0000-0003-2237-2756
Funding
Training Program in Tumor MicroenvironmentT32CA009676 · NCI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Maria G Castro, Analisa Virginia DiFeo · 1992 to 2026
$7.3MOligodendrocyte-focused rAAV gene therapy strategies for Canavan disease and LeukodystrophiesR01NS076991 · NINDS · UNIV OF MASSACHUSETTS MED SCH WORCESTER · PI Guangping Gao · 2012 to 2026
$5.7MImmune-suppressive Myeloid Cells in the Glioma Microenvironment: Signaling Mechanisms and Novel Therapeutic StrategiesR37NS094804 · NINDS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI CASTRO, MARIA G · 2015 to 2021
$2.9MUncover the role of H3.3-G343R mutation in shaping the DNA damage response, anti-tumor immunity and mechanisms of resistance in glioma.R01NS122165 · NINDS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Maria G Castro · 2022 to 2026
$2.5MNeuroimmunology of Malignant Brain Tumors: Innate MechanismsR01NS096756 · NINDS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI LOWENSTEIN, PEDRO R. · 2016 to 2020
$2.1MInteractions between the tumor cells and the neuro-immune microenvironment in mutant IDH1 gliomas: implications for therapeuticsR01NS105556 · NINDS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI CASTRO, MARIA G · 2018 to 2021
$1.9MMechanisms of glioma growth and invasion novel therapeutic strategiesR01NS082311 · NINDS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI LOWENSTEIN, PEDRO R. · 2013 to 2017
$1.7MImmune-mediated therapies in a genetically engineered murine model of diffuse intrinsic pontine gliomaR21NS107894 · NINDS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI CASTRO, MARIA G · 2019 to 2019
$442kNCI NIH HHS T32 CA009676NINDS NIH HHS R01 NS076991NINDS NIH HHS R01 NS082311NINDS NIH HHS R01 NS096756NINDS NIH HHS R01 NS105556NINDS NIH HHS R01 NS122165NINDS NIH HHS R21 NS107894NINDS NIH HHS R37 NS094804
Abstract
Mutant isocitrate-dehydrogenase 1 (
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.