ArticleScience translational medicine2021
Abstract read
In one paragraph
Article in Science translational medicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 66 papers, 1 of them a synthesis that pooled it.
0numbers the graph read from it
0cells of the map it votes in
66citing papers in PubMed, 1 pooled it
–field-weighted citation impact
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
66 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Regulation of autophagy, lipid metabolism, and neurodegenerative pathology by heparan sulfate proteoglycans.Frontiers in genetics · 2022Pooled it
- Review
- Article
- Recent advances in Alzheimer's disease: From molecular mechanisms to therapeutic strategies.Cell · 2026Review
- Understanding the genetic imperfections of Lewy body dementia.Molecular neurodegeneration · 2026Review
- Protective mutations associated with APOE in Alzheimer's disease.Molecular psychiatry · 2026Review
- Alzheimer's Disease: From Pathogenesis to Emerging Therapeutic Targets.Journal of clinical medicine · 2026Review
- Genetic Architecture of Cognitive Resilience in Alzheimer's Disease: Mechanisms, Pathways, and Therapeutic Implications.Neurology international · 2026Review
- Rapamycin Reduces Amyloid-β Plaques and Improves Behavioral Performance in a Sex-Dependent Manner in Mouse Models of Amyloidosis.CNS neuroscience & therapeutics · 2026Article
- Systems biology of Alzheimer's Disease: a scoping review of key pathways and mechanisms.Molecular neurodegeneration · 2026Article
- ApoE expression across the CNS: Who, What, Where, When, and How (much)?Molecular neurodegeneration advances · 2026Review
- Mechanistic role of APOE lipidation in Alzheimer's disease pathogenesis.Theranostics · 2026Review
- ApoE is Secreted as a Lipid Nanoparticle by Mammalian Cells: Implications for Alzheimer's Disease Pathogenesis.Biochemistry · 2025Article
- APOE deficiency inhibits amyloid-facilitated (A) tau pathology (T) and neurodegeneration (N), halting progressive ATN pathology in a preclinical model.Molecular psychiatry · 2025Article
- Review
- The R136S mutation in the APOE3 gene confers resilience against tau pathology via inhibition of the cGAS-STING-IFN pathway.Immunity · 2025Article
- APOE2 reduces risk of Alzheimer's disease by protection of lysosomes from lipid overloading.Acta pharmaceutica Sinica. B · 2025Article
- The APOE-Microglia Axis in Alzheimer's Disease: Functional Divergence and Therapeutic Perspectives-A Narrative Review.Brain sciences · 2025Review
- Protective genetic variants against Alzheimer's disease.The Lancet. Neurology · 2025Review
- Apolipoprotein E in Alzheimer's disease: molecular insights and therapeutic opportunities.Molecular neurodegeneration · 2025Review
6 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
47 authors.
Chia-Chen LiuDepartment of Neuroscience, Mayo Clinic, Jacksonville, FL 32224, USA.ORCID 0000-0001-7203-3926
Melissa E MurrayDepartment of Neuroscience, Mayo Clinic, Jacksonville, FL 32224, USA.ORCID 0000-0001-7379-2545
Xia LiDepartment of Neuroscience, Mayo Clinic, Jacksonville, FL 32224, USA.ORCID 0000-0003-3531-0861
Na ZhaoDepartment of Neuroscience, Mayo Clinic, Jacksonville, FL 32224, USA.ORCID 0000-0001-8648-9422
Na WangDepartment of Neuroscience, Mayo Clinic, Jacksonville, FL 32224, USA.
Michael G HeckmanDivision of Biomedical Statistics and Informatics, Department of Health Sciences Research, Mayo Clinic, Jacksonville, FL 32224, USA.
Francis ShueDepartment of Neuroscience, Mayo Clinic, Jacksonville, FL 32224, USA.ORCID 0000-0003-1659-1952
Yuka MartensDepartment of Neuroscience, Mayo Clinic, Jacksonville, FL 32224, USA.ORCID 0000-0002-5194-4269
Yonghe LiDepartment of Neuroscience, Mayo Clinic, Jacksonville, FL 32224, USA.
Ana-Caroline RaulinDepartment of Neuroscience, Mayo Clinic, Jacksonville, FL 32224, USA.ORCID 0000-0001-5044-9197
Cassandra L RosenbergDepartment of Neuroscience, Mayo Clinic, Jacksonville, FL 32224, USA.
Sydney V DossDepartment of Neuroscience, Mayo Clinic, Jacksonville, FL 32224, USA.ORCID 0000-0002-3427-4654
Jing ZhaoDepartment of Neuroscience, Mayo Clinic, Jacksonville, FL 32224, USA.ORCID 0000-0002-4520-6307
Melissa C WrenDepartment of Neuroscience, Mayo Clinic, Jacksonville, FL 32224, USA.ORCID 0000-0001-9359-4941
Lin JiaDepartment of Neuroscience, Mayo Clinic, Jacksonville, FL 32224, USA.
Yingxue RenDivision of Biomedical Statistics and Informatics, Department of Health Sciences Research, Mayo Clinic, Jacksonville, FL 32224, USA.
Tadafumi C IkezuDepartment of Neuroscience, Mayo Clinic, Jacksonville, FL 32224, USA.ORCID 0000-0002-3511-6009
Wenyan LuDepartment of Neuroscience, Mayo Clinic, Jacksonville, FL 32224, USA.
Yuan FuDepartment of Neuroscience, Mayo Clinic, Jacksonville, FL 32224, USA.
Thomas CaulfieldDepartment of Neuroscience, Mayo Clinic, Jacksonville, FL 32224, USA.ORCID 0000-0002-1055-3069
Zachary A TrottierDepartment of Neuroscience, Mayo Clinic, Jacksonville, FL 32224, USA.ORCID 0000-0003-0040-4294
Joshua KnightDepartment of Neuroscience, Mayo Clinic, Jacksonville, FL 32224, USA.
Yixing ChenDepartment of Neuroscience, Mayo Clinic, Jacksonville, FL 32224, USA.
Cynthia LinaresDepartment of Neuroscience, Mayo Clinic, Jacksonville, FL 32224, USA.
Xue WangDivision of Biomedical Statistics and Informatics, Department of Health Sciences Research, Mayo Clinic, Jacksonville, FL 32224, USA.
Aishe KurtiDepartment of Neuroscience, Mayo Clinic, Jacksonville, FL 32224, USA.
Yan W AsmannDivision of Biomedical Statistics and Informatics, Department of Health Sciences Research, Mayo Clinic, Jacksonville, FL 32224, USA.
Zbigniew K WszolekDepartment of Neurology, Mayo Clinic, Jacksonville, FL 32224, USA.ORCID 0000-0001-5487-1053
Glenn E SmithDepartment of Psychiatry and Psychology, Mayo Clinic, Rochester, MN 55905, USA.
Prashanthi VemuriDepartment of Radiology, Mayo Clinic, Rochester, MN 55905, USA.ORCID 0000-0003-4286-0589
Kejal KantarciDepartment of Radiology, Mayo Clinic, Rochester, MN 55905, USA.
David S KnopmanDepartment of Neurology, Mayo Clinic, Rochester, MN 55905, USA.
Val J LoweDepartment of Radiology, Mayo Clinic, Rochester, MN 55905, USA.
Clifford R JackDepartment of Radiology, Mayo Clinic, Rochester, MN 55905, USA.ORCID 0000-0001-7916-622X
Joseph E ParisiDepartment of Neurology, Mayo Clinic, Rochester, MN 55905, USA.
Tanis J FermanDepartment of Psychiatry and Psychology, Mayo Clinic, Jacksonville, FL 32224, USA.ORCID 0000-0001-8377-6194
Bradley F BoeveDepartment of Neurology, Mayo Clinic, Rochester, MN 55905, USA.ORCID 0000-0002-4153-8187
Neill R Graff-RadfordDepartment of Neurology, Mayo Clinic, Jacksonville, FL 32224, USA.
Ronald C PetersenDepartment of Neurology, Mayo Clinic, Rochester, MN 55905, USA.ORCID 0000-0002-8178-6601
Steven G YounkinDepartment of Neuroscience, Mayo Clinic, Jacksonville, FL 32224, USA.ORCID 0000-0002-7818-3105
John D FryerDepartment of Neuroscience, Mayo Clinic, Scottsdale, AZ 85259, USA.
Hu WangBarshop Institute for Longevity and Aging Studies, San Antonio, TX 78229, USA.
Xianlin HanBarshop Institute for Longevity and Aging Studies, San Antonio, TX 78229, USA.
Carl FriedenDepartment of Biochemistry and Molecular Biophysics, Washington University, St. Louis, MO 63110, USA.ORCID 0000-0002-4471-2427
Dennis W DicksonDepartment of Neuroscience, Mayo Clinic, Jacksonville, FL 32224, USA.ORCID 0000-0001-7189-7917
Owen A RossDepartment of Neuroscience, Mayo Clinic, Jacksonville, FL 32224, USA.ORCID 0000-0003-4813-756X
Guojun BuDepartment of Neuroscience, Mayo Clinic, Jacksonville, FL 32224, USA.ORCID 0000-0003-3491-1016
Funding
SUPPLEMENT TO ALZHEIMERS DISEASE PATIENT REGISTRYU01AG006786 · NIA · MAYO CLINIC ROCHESTER · PI GRAFF-RADFORD, JONATHAN, JACK, CLIFFORD R. · 1986 to 2023
$49.6MProject 4 (Genetic modifiers for APOE-associated Alzheimer's disease pathogenesis)U19AG069701 · NIA · MAYO CLINIC JACKSONVILLE · PI Yingxue Ren · 2021 to 2026
$42.0MResearch Education ComponentP30AG062677 · NIA · MAYO CLINIC ROCHESTER · PI Walter K. Kremers · 2019 to 2026
$33.5MSouth Texas Alzheimer's Disease Research CenterP30AG066546 · NIA · UNIVERSITY OF TEXAS HLTH SCIENCE CENTER · PI Sudha Seshadri · 2021 to 2026
$24.0MLongitudinal Imaging Biomarkers of Prodromal DLBU01NS100620 · NINDS · MAYO CLINIC ROCHESTER · PI Bradley F Boeve, KEJAL KANTARCI · 2017 to 2026
$19.2MUtilization of proteomics and lipidomics to identify modifiers of LBDU54NS110435 · NINDS · MAYO CLINIC JACKSONVILLE · PI DICKSON, DENNIS WILLIAM, MCLEAN, PAMELA J · 2019 to 2023
$14.5MViral Vectors CoreP01NS074969 · NINDS · WASHINGTON UNIVERSITY · PI SNIDER, BARBARA JOY · 2012 to 2021
$13.0MPREDICTING ALZHEIMERS DISEASE WITH MAGNETIC RESONANCER01AG011378 · NIA · MAYO CLINIC ROCHESTER · PI JACK, CLIFFORD R. · 1993 to 2017
$12.1MNeuropathology CoreP50NS072187 · NINDS · MAYO CLINIC JACKSONVILLE · PI DICKSON, DENNIS WILLIAM · 2010 to 2017
$8.7MValidating the New Criteria for Preclinical Alzheimer's diseaseR01AG041851 · NIA · MAYO CLINIC ROCHESTER · PI JACK, CLIFFORD R., KNOPMAN, DAVID S · 2012 to 2021
$6.3MMicroglial apoE in neuroinflammation and Alzheimer's diseaseRF1AG062110 · NIA · MAYO CLINIC ARIZONA · PI FRYER, JOHN DAVID · 2019 to 2019
$4.0MClinicopathologic and Neuroimaging Differences in Alzheimer's Disease VariantsR01AG054449 · NIA · MAYO CLINIC JACKSONVILLE · PI MURRAY, MELISSA ERIN · 2017 to 2021
$3.9MNIA NIH HHS P30 AG062677NIA NIH HHS P30 AG066546NIA NIH HHS R01 AG011378NIA NIH HHS R01 AG015866NIA NIH HHS R01 AG021010NIA NIH HHS R01 AG027924NIA NIH HHS R01 AG041851NIA NIH HHS R01 AG054449NIA NIH HHS R37 AG027924NIA NIH HHS RF1 AG046205NIA NIH HHS RF1 AG057181NIA NIH HHS RF1 AG061872NIA NIH HHS RF1 AG062110NIA NIH HHS U01 AG006786NIA NIH HHS U01 AG052409NIA NIH HHS U19 AG069701NINDS NIH HHS P01 NS074969NINDS NIH HHS P50 NS072187NINDS NIH HHS R01 NS076471NINDS NIH HHS R01 NS078086NINDS NIH HHS U01 NS100620NINDS NIH HHS U54 NS110435
Abstract
Apolipoprotein E (
Indexed as
DementiaApolipoprotein E3Apolipoproteins EHumansApoE protein, humanApolipoprotein E3Apolipoproteins E
Identifiers
What OpenQuestion holds
Textmetadata
LicenceTDM
Read underepoch 390
Registered trials
None linked
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.