Evidence map›Paper›PMID 34586736›Full record

ArticleClinical and translational medicine2021

Metabolomic therapy response prediction in pretherapeutic tissue biopsies for trastuzumab in patients with HER2-positive advanced gastric cancer.

Thomas Kunzke, Fabian T Hölzl, Verena M Prade, Achim Buck, Katharina Huber, Annette Feuchtinger, Karolin Ebert, Gwen Zwingenberger, Robert Geffers, Stefanie M Hauck and 4 more

Abstract readLetter
In one paragraph

Article in Clinical and translational medicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
  2. Observational
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Thomas KunzkeResearch Unit Analytical Pathology, Helmholtz Zentrum München-German Research Center for Environmental Health, Neuherberg, Germany.
Fabian T HölzlResearch Unit Analytical Pathology, Helmholtz Zentrum München-German Research Center for Environmental Health, Neuherberg, Germany.
Verena M PradeResearch Unit Analytical Pathology, Helmholtz Zentrum München-German Research Center for Environmental Health, Neuherberg, Germany.
Achim BuckResearch Unit Analytical Pathology, Helmholtz Zentrum München-German Research Center for Environmental Health, Neuherberg, Germany.
Katharina HuberResearch Unit Analytical Pathology, Helmholtz Zentrum München-German Research Center for Environmental Health, Neuherberg, Germany.
Annette FeuchtingerResearch Unit Analytical Pathology, Helmholtz Zentrum München-German Research Center for Environmental Health, Neuherberg, Germany.
Karolin EbertTechnische Universität München, Fakultät für Medizin, Klinikum rechts der Isar, Institut für Allgemeine Pathologie und Pathologische Anatomie, München, Germany.
Gwen ZwingenbergerTechnische Universität München, Fakultät für Medizin, Klinikum rechts der Isar, Institut für Allgemeine Pathologie und Pathologische Anatomie, München, Germany.
Robert GeffersGenome Analytics Group, Helmholtz Center for Infection Research HZI, Braunschweig, Germany.
Stefanie M HauckResearch Unit Protein Science and Metabolomics and Proteomics Core, Helmholtz Zentrum München-German Research Center for Environmental Health, Neuherberg, Germany.
Ivonne HaffnerUniversity Cancer Center Leipzig (UCCL), Leipzig University Medical Center, Leipzig, Germany.
Birgit LuberTechnische Universität München, Fakultät für Medizin, Klinikum rechts der Isar, Institut für Allgemeine Pathologie und Pathologische Anatomie, München, Germany.
Florian LordickUniversity Cancer Center Leipzig (UCCL), Leipzig University Medical Center, Leipzig, Germany.
Axel WalchResearch Unit Analytical Pathology, Helmholtz Zentrum München-German Research Center for Environmental Health, Neuherberg, Germany.ORCID 0000-0001-5578-4023

Funding

Deutsche Forschungsgemeinschaft SFB 824TP C04Ministry of Education and Research of the Federal Republic of Germany: 01KT1615Ministry of Education and Research of the Federal Republic of Germany: 01ZX1610AMinistry of Education and Research of the Federal Republic of Germany: 01ZX1610B
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

Stomach NeoplasmsAntineoplastic Agents, ImmunologicalBiopsyDrug Resistance, NeoplasmErb-b2 Receptor Tyrosine KinasesHumansMetabolomeStomachTrastuzumabAntineoplastic Agents, ImmunologicalErb-b2 Receptor Tyrosine KinasesTrastuzumab

Identifiers

PMID34586736
PMCPMC8473480

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.