Evidence map›Paper›PMID 34586728›Full record

ArticleClinical and translational medicine2021

Interplay of m

Fuxi Li, Siyun Chen, Jiaming Yu, Zhuoxing Gao, Zhangyi Sun, Yang Yi, Teng Long, Chuanxia Zhang, Yuzhe Li, Yimin Pan and 4 more

Open access · goldAbstract read
In one paragraph

Article in Clinical and translational medicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 61 papers.

0numbers the graph read from it
0cells of the map it votes in
61citing papers in PubMed
4.4field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

61 citing papers in PubMed, 69 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Article
  5. Review
  6. Article
  7. Article
  8. Article
  9. Article
  10. Review
  11. Review
  12. RNA mCell investigation · 2025
    Article
  13. Article
  14. Exploring the methyl-verse: Dynamic interplay of epigenome and m6A epitranscriptome.Molecular therapy : the journal of the American Society of Gene Therapy · 2025
    Review
  15. Article
  16. Review
  17. Article
  18. Review
  19. Article
  20. Review

1 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 3 institutions in 1 country.

Fuxi LiState Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University, Guangzhou, China.
Siyun ChenKey Laboratory of Stem Cells and Tissue Engineering, Sun Yat-Sen University, Ministry of Education, Guangzhou, China.
Jiaming YuKey Laboratory of Stem Cells and Tissue Engineering, Sun Yat-Sen University, Ministry of Education, Guangzhou, China.
Zhuoxing GaoGuangdong Provincial People's Hospital, Guangdong Academy of Medical Sciences, Guangzhou, China.
Zhangyi SunKey Laboratory of Stem Cells and Tissue Engineering, Sun Yat-Sen University, Ministry of Education, Guangzhou, China.
Yang YiKey Laboratory of Stem Cells and Tissue Engineering, Sun Yat-Sen University, Ministry of Education, Guangzhou, China.
Teng LongKey Laboratory of Stem Cells and Tissue Engineering, Sun Yat-Sen University, Ministry of Education, Guangzhou, China.
Chuanxia ZhangGuangdong Provincial People's Hospital, Guangdong Academy of Medical Sciences, Guangzhou, China.
Yuzhe LiNeurosurgery Department, Xiangya Hospital, Central South University, Changsha, China.
Yimin PanNeurosurgery Department, Xiangya Hospital, Central South University, Changsha, China.
Chaoying QinNeurosurgery Department, Xiangya Hospital, Central South University, Changsha, China.
Wenyong LongNeurosurgery Department, Xiangya Hospital, Central South University, Changsha, China.
Qing LiuNeurosurgery Department, Xiangya Hospital, Central South University, Changsha, China.
Wei ZhaoGuangdong Provincial People's Hospital, Guangdong Academy of Medical Sciences, Guangzhou, China.ORCID 0000-0002-0774-2571
Sun Yat-sen University · CNCentral South University · CNGuangdong Academy of Medical Sciences · CN

Funding

Guangdong Innovative and Entrepreneurial Research Team Program 2016ZT06S029National Key Research and Development Program of China 2017YFA0103800National Natural Science Foundation of China 31771630National Natural Science Foundation of China 81702784National Natural Science Foundation of China 81802974National Natural Science Foundation of China 81972651Natural Science Foundation of Guangdong Province 2017A030312009
6 · The paper itself

Abstract

backgroundDespite the development of new treatment protocols for glioblastoma (GBM), temozolomide (TMZ) resistance remains a primary hindrance. Previous studies, including our study, have shown that aberrant N6-methyladenosine (m

methodsm

resultsWe demonstrated that TMZ treatment upregulated the expression of the m

conclusionsOur findings uncover the fundamental mechanisms underlying the interplay of m

Indexed as

Drug Resistance, NeoplasmAdenosineAnimalsAntineoplastic Agents, AlkylatingBrain NeoplasmsCell Line, TumorFemaleGlioblastomaHistone CodeHumansMiceMice, Inbred BALB CTemozolomideAdenosineAntineoplastic Agents, AlkylatingN-methyladenosineTemozolomideglioblastomahistone modificationsm6AMETTL3TMZ resistance

Identifiers

PMID34586728
PMCPMC8441140
OpenAlexW3200841564

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.