ReviewChembiochem : a European journal of chemical biology2022
"A Study in Yellow": Investigations in the Stereoselectivity of Ene-Reductases.
Review in Chembiochem : a European journal of chemical biology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 52 citations in OpenAlex.
- Asymmetric synthesis of alkyl fluoridesGreen chemistry : an international journal and green chemistry resource : GC · 2026Article
- Dynamic Enantioconvergent Desaturation of 4,5-Disubstituted γ-Lactones in Whole Cells ofJournal of the American Chemical Society · 2026Article
- Structural and functional characterization of a new thermophilic-like OYE from Aspergillus flavus.Applied microbiology and biotechnology · 2024Article
- Cooperative chemoenzymatic and biocatalytic cascades to access chiral sulfur compounds bearing C(spNature communications · 2024Article
- Deciphering the Unconventional Reduction of C=N Bonds by Old Yellow Enzymes Using QM/MM.ACS catalysis · 2024Article
- Biocatalytic reduction of alkenes in micro-aqueous organic solvent catalysed by an immobilised ene reductase.Catalysis science & technology · 2023Article
- Purification and biochemical characterization of a novel ene- reductase from Kazachstania exigua HSC6 for dihydro-β-ionone from β-ionone.Biotechnology letters · 2023Article
- Engineering of an ene-reductase for producing the key intermediate of antiepileptic drug Brivaracetam.Applied microbiology and biotechnology · 2023Article
- One-Pot Biocatalytic Synthesis of Primary, Secondary, and Tertiary Amines with Two Stereocenters from α,β-Unsaturated Ketones Using Alkyl-Ammonium Formate.ACS catalysis · 2022Article
- Chemoenzymatic Synthesis of the Most Pleasant Stereoisomer of Jessemal.The Journal of organic chemistry · 2022Article
- Stereoselective Biocatalyzed Reductions of Ginger Active Components Recovered from Industrial Wastes.Chembiochem : a European journal of chemical biology · 2022Article
- "A Study in Yellow": Investigations in the Stereoselectivity of Ene-Reductases.Chembiochem : a European journal of chemical biology · 2022Review
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Ene-reductases from the Old Yellow Enzyme (OYE) superfamily are a well-known and efficient biocatalytic alternative for the asymmetric reduction of C=C bonds. Considering the broad variety of substituents that can be tolerated, and the excellent stereoselectivities achieved, it is apparent why these enzymes are so appealing for preparative and industrial applications. Different classes of C=C bonds activated by at least one electron-withdrawing group have been shown to be accepted by these versatile biocatalysts in the last decades, affording a vast range of chiral intermediates employed in the synthesis of pharmaceuticals, agrochemicals, flavours, fragrances and fine chemicals. In order to access both enantiomers of reduced products, stereodivergent pairs of OYEs are desirable, but their natural occurrence is limited. The detailed knowledge of the stereochemical course of the reaction can uncover alternative strategies to orient the selectivity via mutagenesis, evolution, and substrate engineering. An overview of the ongoing studies on OYE-mediated bioreductions will be provided, with particular focus on stereochemical investigations by deuterium labelling.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.