Evidence map›Paper›PMID 34586605›Full record

ArticleBiological trace element research2022

Circulatory Imbalance of Essential and Toxic Trace Elements in Pre-dialysis and Hemodialysis Patients.

Aleksandar Stojsavljević, Danijela Ristić-Medić, Đurđa Krstić, Branislav Rovčanin, Slavica Radjen, Brankica Terzić, Dragan Manojlović

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Biological trace element research, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed, 1 pooled it
1.4field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 1 synthesis or guideline pooled it, 17 citations in OpenAlex.

  1. Pooled it
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 4 institutions in 2 countries.

Aleksandar StojsavljevićFaculty of Chemistry, University of Belgrade, Studentski trg 12-16, Belgrade, Serbia. aleksandars@chem.bg.ac.rs.
Danijela Ristić-MedićGroup for Nutritional Biochemistry and Dietology, Centre of Research Excellence in Nutrition and Metabolism, Institute for Medical Research, National Institute of Republic of Serbia, 11000, Belgrade, Serbia.
Đurđa KrstićFaculty of Chemistry, University of Belgrade, Studentski trg 12-16, Belgrade, Serbia.
Branislav RovčaninCenter for Endocrine Surgery, University Clinical Center of Serbia, Koste Todorovića 8, Belgrade, Serbia.
Slavica RadjenMedical Faculty of the Military Medical Academy, University of Defence, Belgrade, Serbia.
Brankica TerzićInstitute of Hygiene, Military Medical Academy, Belgrade, Serbia.
Dragan ManojlovićFaculty of Chemistry, University of Belgrade, Studentski trg 12-16, Belgrade, Serbia.
Military Medical Academy · RSUniversity of Belgrade · RSCentre of Research Excellence in Nutrition and Metabolism · RSSouth Ural State University · RU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The status of essential and toxic trace elements in patients with different stages of chronic kidney disease (CKD) is still unclear and not well characterized. The present study examined the circulatory levels of a wide panel of trace elements (Al, Cr, Mn, Co, Ni, Cu, Zn, As, Se, Rb, Sr, Cd, Pb, and U) in hemodialysis patients (HD group) and pre-dialysis patients with stage 3 CKD (PD group). Comparisons were made between groups of patients and healthy individuals from the control group (CG). The levels of Al, Mn, Co, Ni, Cu, As, Se, Sr, and Pb were higher, while the levels of Cr, Zn, Rb, Cd, and U were lower in HD patients than in our CG. Higher levels of Al and Se, as well as lower levels of As, Sr, Zn, Rb, and U were significant and distinguished HD from PD. Among other analyzed elements, Co, Se, and U are the only trace elements that did not distinguish PD from CG at a statistically significant level. The HD group had lower serum U levels than the PD group, and this could be a result of hemodialysis. This study also revealed that the Cu/Zn ratio could be used as a marker for early and late detection of renal failure. Marked changes of essential and toxic trace element levels in sera indicate additional pathophysiological events in CKD, which could additionally contribute to the preexisting increased morbidity of HD patients. Measurement of trace elements in HD patients should be performed routinely.

Indexed as

Renal Insufficiency, ChronicTrace ElementsCadmiumDialysisHumansLeadRenal DialysisCadmiumLeadTrace ElementsEssential trace elementsHemodialysis patientsPre-dialysis patientsToxic trace elements

Identifiers

PMID34586605
PMCPMC8479265
OpenAlexW3202609495

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.