Evidence map›Paper›PMID 34586586›Full record

ArticleNeurochemical research2022

Neuropeptide α-Melanocyte-Stimulating Hormone Promotes Neurological Recovery and Repairs Cerebral Ischemia/Reperfusion Injury in Type 1 Diabetes.

Rajesh Kumar Goit, Tsz Chung Ng, Ka Cheung Tam, Jessica K W Tsang, Andrew W Taylor, Amy C Y Lo

Abstract read
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In one paragraph

Article in Neurochemical research, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.5field-weighted citation impact, top 37% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 6 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 2 countries.

Rajesh Kumar GoitDepartment of Ophthalmology, LKS Faculty of Medicine, The University of Hong Kong, Hong Kong, China.
Tsz Chung NgDepartment of Ophthalmology, LKS Faculty of Medicine, The University of Hong Kong, Hong Kong, China.
Ka Cheung TamDepartment of Ophthalmology, LKS Faculty of Medicine, The University of Hong Kong, Hong Kong, China.
Jessica K W TsangDepartment of Ophthalmology, LKS Faculty of Medicine, The University of Hong Kong, Hong Kong, China.
Andrew W TaylorDepartment of Ophthalmology, Boston University School of Medicine, Boston, MA, USA. awtaylor@bu.edu.ORCID http://orcid.org/0000-0002-0330-8591
Amy C Y LoDepartment of Ophthalmology, LKS Faculty of Medicine, The University of Hong Kong, Hong Kong, China. amylo@hku.hk.ORCID http://orcid.org/0000-0003-4239-6851
University of Hong Kong · HKBoston University · US

Funding

General Research Fund, Research Grants Council, The Government of the Hong Kong Special Administrative Region 17112919The University of Hong Kong Seed Funding Programme for Basic Research 201811159123
6 · The paper itself

Abstract

Persons with type 1 diabetes have an increased risk of stroke compared with the general population. α-Melanocyte-stimulating hormone (α-MSH) is a neuropeptide that has protective effects against ischemia/reperfusion (I/R) induced organ damages. In this study, we aimed to investigate the neuroprotective role of this peptide on I/R induced brain damage after experimental stroke associated with hyperglycemia using C57BL/6J Ins2

Indexed as

Brain IschemiaDiabetes Mellitus, Type 1Reperfusion Injuryalpha-MSHAnimalsHumansMiceMice, Inbred C57BLalpha-MSHBrainHyperglycemiaInflammationIschemiaOxidative stressReperfusion

Identifiers

PMID34586586
OpenAlexW3203630590

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.