Evidence map›Paper›PMID 34586534›Full record

ArticleGlycoconjugate journal2021

The interaction of folate-modified Bletilla striata polysaccharide-based micelle with bovine serum albumin.

Xinying Wang, Guangyuan Zhang, Di Yu, Ning Wang, Qingxiang Guan

Abstract read
PubMed Publisher
In one paragraph

Article in Glycoconjugate journal, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
1.0field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 7 citations in OpenAlex.

  1. Molecules (Basel, Switzerland) · 2026
    Review
  2. Recent advances inFrontiers in pharmacology · 2025
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Xinying Wang *Department of Pharmaceutics, School of Pharmacy, Jilin University, No. 1266, Fujin Road, Changchun, 130021, China.
Guangyuan Zhang *Department of Pharmaceutics, School of Pharmacy, Jilin University, No. 1266, Fujin Road, Changchun, 130021, China.
Di YuDepartment of Pharmaceutics, School of Pharmacy, Jilin University, No. 1266, Fujin Road, Changchun, 130021, China.
Ning WangDepartment of Pharmaceutics, School of Pharmacy, Jilin University, No. 1266, Fujin Road, Changchun, 130021, China.
Qingxiang GuanDepartment of Pharmaceutics, School of Pharmacy, Jilin University, No. 1266, Fujin Road, Changchun, 130021, China. guanqx@jlu.edu.cn.
Jilin University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

We fabricated an amphiphilic folate-modified Bletilla striata polysaccharide (FA-BSP-SA) copolymer that exhibited good biocompatibility and superior antitumor effects. This study investigated the affinity between FA-BSP-SA and bovine serum albumin (BSA) via multispetroscopic approaches. Changes in the morphology and particle size showed that FA-BSP-SA formed a blurry "protein corona". Stern-Volmer equation demonstrated that FA-BSP-SA micelles decreased the fluorescence of BSA via static quenching. The measurement results of thermodynamic parameters (entropy change, enthalpy change, and Gibbs free energy) suggested that the binding between FA-BSP-SA and BSA was spontaneous in which Van der Waals forces and hydrogen bonding played major roles. The results from synchronous fluorescence, circular dichroism, and UV spectra also revealed that BSA conformation was slightly altered by decreasing α-helical contents. In addition, the antitumor effects in vitro of Dox@FA-BSP-SA micelles and the cellular uptake behavior of micelles in 4T1 cells were decreased after incubating with BSA.

Indexed as

MicellesAnimalsAntibiotics, AntineoplasticAnticoagulantsAnti-Inflammatory Agents, Non-SteroidalCell Line, TumorDoxorubicinFolic AcidIbuprofenMiceModels, MolecularPolysaccharidesProtein BindingProtein ConformationProtein DomainsSerum Albumin, BovineAntibiotics, AntineoplasticAnticoagulantsAnti-Inflammatory Agents, Non-SteroidalDoxorubicinFolic AcidIbuprofenMicellespolysaccharide b, Bletilla striataPolysaccharidesSerum Albumin, BovineWarfarinAntitumor effectsBinding interactionBSAFluorescence quenchingThermodynamic parameters

Identifiers

PMID34586534
OpenAlexW3203427742

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.