ArticleBreast cancer research and treatment2021
Sleep medication use and risk of fractures in breast cancer survivors.
Article in Breast cancer research and treatment, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed, 12 citations in OpenAlex.
- Study on the Effect of Positive Psychological Intervention Based on PERMA Model on Perioperative Patients with AIDS Complicated with Breast Cancer.Computational and mathematical methods in medicine · 2022Trial
- Substance use risk and controlled substances discussions in cancer care: Observations from audio-recorded patient-clinician encounters.Palliative & supportive care · 2026Article
- Progressive Muscle Relaxation as an Alternative Therapy for Death Anxiety and Sleep Quality in End-Stage Cancer Patients: An Experimental Study.Health science reports · 2026Article
- Review
- Sleep disturbances based on patient reported outcomes in patients with breast cancer.Sleep & breathing = Schlaf & Atmung · 2024Article
- Sleep and risk of hip fracture and falls among middle-aged and older Chinese.Scientific reports · 2024Article
- Socioeconomic Status, Stress, and Cancer-related Fatigue among Chinese American Breast Cancer Survivors: The Mediating Roles of Sleep.Asian American journal of psychology · 2024Article
- Mi Sleep Coach Mobile App to Address Insomnia Symptoms Among Cancer Survivors: Single-Arm Feasibility Study.JMIR formative research · 2024Article
- Article
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeSleep problems are more common in breast cancer survivors than those without a cancer history. Our goal was to examine the risk of fractures among breast cancers survivors who used prescription sleep aids.
methodsWe conducted a retrospective cohort study of 21,346 adult women diagnosed with stage 0-III breast cancer between 2009 and 2016 and followed them through 2017. We examined person-year rates of fractures by sleep medication use and calculated adjusted hazard ratios (HR) and 95% confidence intervals (CI) with Cox proportional hazards models using time-dependent variables for sleep medications and covariate medications (antidepressants, anti-anxiety medications, and bisphosphonates) adjusted for demographics, comorbidities, and tumor characteristics and cancer treatments.
resultsThe sleep medication use was common (40%) in breast cancer survivors and was associated with a 33% increased risk of fractures (adjusted HR = 1.33, 95% CI: 1.20-1.49). Further, in a sensitivity analysis based on new use of sleep medication, the fracture risk was even stronger (adjusted HR = 1.44, 95% CI: 1.26-1.64).
conclusionGiven the high use of sleep medications and the high risk of fractures in breast cancer survivors, this study suggests that non-pharmacologic management of sleep problems might be considered as alternative therapy.
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