Evidence map›Paper›PMID 34586408›Full record

SynthesisQJM : monthly journal of the Association of Physicians2023

Acute myocardial infarction and myocarditis following COVID-19 vaccination.

Y N Aye, A S Mai, A Zhang, O Z H Lim, N Lin, C H Ng, M Y Chan, J Yip, P-H Loh, N W S Chew

Open access · greenAbstract readSystematic Review
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in QJM : monthly journal of the Association of Physicians, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 43 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
43citing papers in PubMed, 2 pooled it
13.4field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

43 citing papers in PubMed, 2 syntheses or guidelines pooled it, 75 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 1 institution in 1 country.

Y N AyeDepartment of Cardiology, National University Heart Centre, Singapore, Singapore.
A S MaiYong Loo Lin School of Medicine. Singapore 117597.
A ZhangDepartment of Cardiology, National University Heart Centre, Singapore, Singapore.
O Z H LimYong Loo Lin School of Medicine. Singapore 117597.
N LinDepartment of Cardiology, National University Heart Centre, Singapore, Singapore.
C H NgYong Loo Lin School of Medicine. Singapore 117597.
M Y ChanDepartment of Cardiology, National University Heart Centre, Singapore, Singapore.
J YipDepartment of Cardiology, National University Heart Centre, Singapore, Singapore.
P-H LohDepartment of Cardiology, National University Heart Centre, Singapore, Singapore.
N W S ChewDepartment of Cardiology, National University Heart Centre, Singapore, Singapore.ORCID 0000-0002-0640-0430
National University Heart Centre Singapore · SG

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Emerging reports raise concerns on the potential association between the COVID-19 vaccines and cardiac manifestations. We sought to evaluate cardiac complications associated with COVID-19 vaccination in a pooled analysis from our institution's cohort study and systematic review. Consecutive patients admitted to a tertiary hospital in Singapore between 1 January 2021 and 31 March 2021, with the onset of cardiac manifestations within 14 days following COVID-19 vaccination, were studied. Furthermore, a systematic review was performed, with PubMed, Embase, Research Square, MedRxiv and LitCovid databases accessed from inception up to 29 June 2021. Relevant manuscripts reporting individual patient data on cardiac complications following COVID-19 vaccination were included. Thirty patients were included in the study cohort, with 29 diagnosed with acute myocardial infarction (AMI) and 1 with myocarditis. Five patients developed heart failure, two had cardiogenic shock, three intubated, and one had cardiovascular-related mortality. In the systematic review, 16 studies were included with 41 myocarditis and 6 AMI cases. In the pooled analysis of the study cohort and the systematic review, 35 patients had AMI and 42 had myocarditis. Majority were men, and myocarditis patients were younger than AMI patients. Myocarditis patients tended to present 72 h postvaccination, while AMI patients were older and typically presented 24 h postvaccination. Majority with AMI or myocarditis developed symptoms after the first and second vaccination dose, respectively. This pooled analysis of patients presenting with cardiac manifestations following COVID-19 vaccination highlights the differences between myocarditis and AMI presentations in temporal association with the vaccination.

Indexed as

COVID-19Myocardial InfarctionMyocarditisCohort StudiesCOVID-19 VaccinesFemaleHumansMaleVaccinationCOVID-19 Vaccines

Identifiers

PMID34586408
PMCPMC8522388
OpenAlexW3202333603

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.