ArticleArquivos brasileiros de oftalmologia2021
Retinal microvascular changes in patients with familial mediterranean fever: a study based on optical coherence tomography angiography.
Article in Arquivos brasileiros de oftalmologia, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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4 citing papers in PubMed.
- Severe tortuosity but not altered retinal vessel diameters in children and young adults with Familial Mediterranean Fever: a case-control study.Rheumatology international · 2026Article
- Retinal changes in children with Familial Mediterranean Fever: the effect of chronic subclinical inflammation.Pediatric research · 2026Article
- Vascular characteristics of pediatric patients with familial Mediterranean fever: a study of optical coherence tomography angiography findings.Japanese journal of ophthalmology · 2025Observational
- Update on ocular manifestations of the main monogenic and polygenic autoinflammatory diseases.Frontiers in ophthalmology · 2024Review
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8 authors.
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Abstract
purposeIn this study, we aimed to show whether a difference exists between retinal and choroidal microcirculation findings between patients with familial Mediterranean fever and healthy controls.
methodsThirty-two patients with familial Mediterranean fever and 30 healthy controls were included in the study. All the patients underwent a complete ophthalmologic examination, including best-corrected visual acuity and intraocular pressure measurement. The AngioVue optical coherence tomography angiography device (Optovue, Fremont, CA) with split-spectrum amplitude-decorrelation angiography was used to evaluate and examine the retinal microvascular structure. Three-dimensional en face Optical coherence tomography angiography images were obtained by examining the macula using the 3 x 3 mm scanning protocol in the Angio Retina mode and the optic nerve using the 3 x 3 mm scanning protocol in the Angio Disk mode. All the patients' right eyes were examined.
resultsA total of 62 subjects were included in the study, of whom 32 (53.3%) were female and 30 (46.7%) were male. No statistically significant difference was found between the two groups in terms of optic nerve head or radial peripapillary capillary vessel density. On examination, the superficial capillary plexuses were statistically similar between the two groups, but the deep capillary plexus vessel density in the parafovea, superior hemi, temporal, and superior areas were significantly lower in the patients with familial Mediterranean fever.
conclusionsWe found that the capillary plexus vessel density was significantly lower in the parafovea, superior hemi, temporal, and superior regions in the patients with familial Mediterranean fever than in the control group. Therefore, OCTA, a noninvasive study, may be useful for understanding the systemic effects of familial Mediterranean fever.
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