ArticleeLife2021
Abstract read
In one paragraph
Article in eLife, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 40 papers, 1 of them a synthesis that pooled it.
0numbers the graph read from it
0cells of the map it votes in
40citing papers in PubMed, 1 pooled it
–field-weighted citation impact
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
40 citing papers in PubMed, 1 synthesis or guideline pooled it.
- APOE ε4 and Dietary Patterns in Relation to Cognitive Function: An Umbrella Review of Systematic Reviews.Nutrition reviews · 2025Pooled it
- Divergent biological consequences of APOE isoforms across industrialized and non-industrial environments.PLoS genetics · 2026Article
- Cross-tissue immune profiling of APOE ε4 reveals early dysregulation in Alzheimer's disease.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026Article
- Plasma proteomic signatures of cellular aging predict human disease.Nature medicine · 2026Article
- Conserved Pathways, Divergent Outcomes: A Cross-Species Genomic Perspective on the Cancer-Neurodegeneration Paradox.International journal of molecular sciences · 2026Review
- Divergent Biological Consequences of APOE Isoforms Across Industrialized and Non-Industrial Environments.bioRxiv : the preprint server for biology · 2026Article
- Cellular Aging Signatures in the Plasma Proteome Record Human Health and Disease.bioRxiv : the preprint server for biology · 2026Article
- Autophagy-lysosomal pathway in neurodegeneration.Molecular neurodegeneration advances · 2026Review
- Comorbidity sequence, sex, and APOE-genotype forecast Alzheimer's disease diagnosis.Frontiers in medicine · 2026Article
- Longitudinal associations between lipid panel and cognitive decline modified by APOE 4 carrier status in biracial community-dwelling older adults: Findings from the Chicago health and aging project.Archives of gerontology and geriatrics · 2025Article
- The First Japanese Case of Familial Hypercholesterolemia Caused by an apolipoprotein E (APOE) p.Leu167del Mutation.Internal medicine (Tokyo, Japan) · 2025Article
- APOE genotype confers context-dependent neurovascular vulnerability in immune-vascularized human forebrain organoids.bioRxiv : the preprint server for biology · 2025Article
- Article
- Is the Relationship Between Cardiovascular Disease and Alzheimer's Disease Genetic? A Scoping Review.Genes · 2024Article
- Article
- Increases in regional brain volume across two native South American male populations.GeroScience · 2024Article
- Elevated blood glucose levels are associated with the progression of brain hypometabolism, and HDL-C andmedRxiv : the preprint server for health sciences · 2024Article
- The biphasic impact of apolipoprotein E ε4 allele on age-related hearing loss.Scientific reports · 2024Article
- Apolipoprotein ɛ4 Is Associated With Increased Risk of Fall- and Fracture-Related Hospitalization: The Perth Longitudinal Study of Ageing Women.The journals of gerontology. Series A, Biological sciences and medical sciences · 2024Article
- Apolipoprotein E polymorphisms and female fertility in a transgenic mouse model of Alzheimer's disease.Scientific reports · 2024Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
15 authors.
Angela R GarciaCenter for Evolution and Medicine, Arizona State University, Tempe, United States.ORCID 0000-0002-6685-5533
Caleb FinchLeonard Davis School of Gerontology, Dornsife College, University of Southern California, Los Angeles, Los Angeles, United States.ORCID 0000-0002-7617-3958
Margaret GatzCenter for Economic and Social Research, University of Southern California, Los Angeles, Los Angeles, United States.ORCID 0000-0002-1071-9970
Thomas KraftDepartment of Anthropology, University of California, Santa Barbara, Santa Barbara, United States.
Daniel Eid RodriguezDepartment of Medicine, Universidad de San Simón, Cochabamba, Bolivia.
Daniel CummingsInstitute for Economics and Society, Chapman University, Orange, United States.
Mia CharifsonVilcek Institute of Graduate Biomedical Sciences, New York University, New York, United States.
Kenneth BuetowCenter for Evolution and Medicine, Arizona State University, Tempe, United States.
Bret A BeheimDepartment of Human Behavior, Ecology and Culture, Max Planck Institute for Evolutionary Anthropology, Leipzig, Germany.
Hooman AllayeeDepartment of Preventive Medicine and Biochemistry & Molecular Medicine, Keck School of Medicine, University of Southern California, Irvine, Irvine, United States.ORCID 0000-0002-2384-5239
Gregory S ThomasLong Beach Memorial, Long Beach and University of California Irvine, Irvine, United States.
Jonathan StieglitzInstitute for Advanced Study in Toulouse, Universite Toulouse, Toulouse, France.ORCID 0000-0001-5985-9643
Michael D Gurven *Department of Anthropology, University of California, Santa Barbara, Santa Barbara, United States.ORCID 0000-0002-5661-527X
Hillard Kaplan *Institute for Economics and Society, Chapman University, Orange, United States.
Benjamin C Trumble *School of Human Evolution and Social Change, Arizona State University, Tempe, United States.
Funding
The Human Life Course and the Biodemography of AgingR01AG024119 · NIA · UNIVERSITY OF CALIFORNIA SANTA BARBARA · PI GURVEN, MICHAEL DOUGLAS, KAPLAN, HILLARD S · 2004 to 2015
$7.4MThe Human Life Course and the Biodemography of AgingR56AG024119 · NIA · UNIVERSITY OF CALIFORNIA SANTA BARBARA · PI GURVEN, MICHAEL DOUGLAS, KAPLAN, HILLARD S · 2009 to 2015
$1.0MNIA NIH HHS R01 AG024119NIA NIH HHS R56 AG024119
Abstract
In post-industrial settings, apolipoprotein
Indexed as
Immunity, InnateIndians, South AmericanTropical ClimateApolipoprotein E4BiomarkersBody Mass IndexBoliviaDietFemaleGenotypeHumansLife StyleLipidsMaleMiddle AgedObesityApolipoprotein E4BiomarkersLipidsAlzheimer's diseaseAPOEcardiovascular diseasecholesteroldementiaevolutionary biologyhumaninflammationmedicine
Identifiers
What OpenQuestion holds
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LicenceCC BY
Read underepoch 390
Registered trials
None linked
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.