Evidence map›Paper›PMID 34585976›Full record

ArticleMicrobiology spectrum2021

SARS-CoV-2 Antibody Testing in Health Care Workers: A Comparison of the Clinical Performance of Three Commercially Available Antibody Assays.

Niamh Allen, Melissa Brady, Antonio Isidro Carrion Martin, Lisa Domegan, Cathal Walsh, Elaine Houlihan, Colm Kerr, Lorraine Doherty, Joanne King, Martina Doheny and 18 more

Open access · goldAbstract readComparative Study
In one paragraph

Article in Microbiology spectrum, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
1.4field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 23 citations in OpenAlex.

  1. Article
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  3. SARS-CoV-2 seropositivity among healthcare professionals in a rural state.Antimicrobial stewardship & healthcare epidemiology : ASHE · 2024
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

28 authors at 6 institutions in 3 countries.

Niamh Allen *Department of GU Medicine and Infectious Diseases, St. James's Hospital, Dublin, Ireland.ORCID 0000-0002-6638-9536
Melissa Brady *Health Service Executive-Health Protection Surveillance Centre (HPSC), Dublin, Ireland.
Antonio Isidro Carrion MartinDepartment of Public Health, University of Murcia, Murcia, Spain.
Lisa DomeganHealth Service Executive-Health Protection Surveillance Centre (HPSC), Dublin, Ireland.
Cathal WalshHealth Service Executive-Health Protection Surveillance Centre (HPSC), Dublin, Ireland.
Elaine HoulihanDepartment of Microbiology, University Hospital Galwaygrid.412440.7, Galway, Ireland.
Colm KerrDepartment of GU Medicine and Infectious Diseases, St. James's Hospital, Dublin, Ireland.
Lorraine DohertyHealth Service Executive-Health Protection Surveillance Centre (HPSC), Dublin, Ireland.
Joanne KingDepartment of Virology, University Hospital Galwaygrid.412440.7, Galway, Ireland.
Martina DohenyDepartment of Clinical Biochemistry, University Hospital Galwaygrid.412440.7, Galway, Ireland.
Damian GriffinDepartment of Clinical Biochemistry, University Hospital Galwaygrid.412440.7, Galway, Ireland.
Maria MolloyGalway University Hospital Group, Galway, Ireland.
Jean DunneDepartment of Immunology, St. James's Hospital, Dublin, Ireland.
Vivion CrowleyDepartment of Biochemistry, St. James's Hospital, Dublin, Ireland.
Philip HolmesDepartment of Biochemistry, St. James's Hospital, Dublin, Ireland.
Evan KeoghDepartment of Biochemistry, St. James's Hospital, Dublin, Ireland.
Sean NaughtonDepartment of Biochemistry, St. James's Hospital, Dublin, Ireland.
Martina KellyDepartment of Virology, St. James's Hospital, Dublin, Ireland.
Fiona O'RourkeDepartment of Virology, St. James's Hospital, Dublin, Ireland.
Yvonne LynaghDepartment of Virology, St. James's Hospital, Dublin, Ireland.
Brendan CrowleyDepartment of Virology, St. James's Hospital, Dublin, Ireland.
Cillian de GascunNational Virus Reference Laboratory, Dublin, Ireland.
Paul HolderNational Virus Reference Laboratory, Dublin, Ireland.
Colm BerginDepartment of GU Medicine and Infectious Diseases, St. James's Hospital, Dublin, Ireland.
Catherine FlemingDepartment of Infectious Diseases, University Hospital Galwaygrid.412440.7, Galway, Ireland.
Una Ni RiainDepartment of Microbiology, University Hospital Galwaygrid.412440.7, Galway, Ireland.
Niall ConlonDepartment of Immunology, St. James's Hospital, Dublin, Ireland.
PRECISE Study Steering Group
St. James's Hospital · IEUniversity Hospital Galway · IEHealth Service Executive · IETrinity College Dublin · IEUniversidad de Murcia · ESUniversity of Limerick · IE

Funding

Health Service Executive COVID-19 budgetScience Foundation Ireland (SFI) 20/SPP/3685
6 · The paper itself

Abstract

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) antibodies are an excellent indicator of past COVID-19 infection. As the COVID-19 pandemic progresses, retained sensitivity over time is an important quality in an antibody assay that is to be used for the purpose of population seroprevalence studies. We compared 5,788 health care worker (HCW) serum samples by using two serological assays (Abbott SARS-CoV-2 anti-nucleocapsid immunoglobulin G (IgG) and Roche anti-SARS-CoV-2 anti-nucleocapsid total antibody) and a subset of samples (all Abbott assay positive or grayzone,

Indexed as

AdultAntibodies, ViralCoronavirus Nucleocapsid ProteinsCOVID-19COVID-19 Serological TestingCross-Sectional StudiesEnzyme-Linked Immunosorbent AssayFemaleHealth PersonnelHumansImmunoglobulin GMaleMiddle AgedPhosphoproteinsSARS-CoV-2Sensitivity and SpecificityAntibodies, ViralCoronavirus Nucleocapsid ProteinsImmunoglobulin Gnucleocapsid phosphoprotein, SARS-CoV-2PhosphoproteinsSpike Glycoprotein, Coronavirusspike protein, SARS-CoV-2Abbott Architect SARS-CoV-2 IgGantibody assays SARS-CoV-2COVID-19 serological assaysRoche Elecsys SARS-CoV-2 panantibodySARS-CoV-2 serological assaySARS-CoV-2 seroprevalence

Identifiers

PMID34585976
PMCPMC8557912
OpenAlexW3204616488

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.