ArticleJournal of cachexia, sarcopenia and muscle2021
Geriatric Nutrition Risk Index: Prognostic factor related to inflammation in elderly patients with cancer cachexia.
Article in Journal of cachexia, sarcopenia and muscle, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 69 papers, 3 of them syntheses that pooled it.
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Who cites it
69 citing papers in PubMed, 3 syntheses or guidelines pooled it, 106 citations in OpenAlex.
- The association between geriatric nutritional risk index and mortality risk of patients after transcatheter aortic valve replacement: a meta-analysis.Frontiers in nutrition · 2026Pooled it
- Geriatric nutritional risk index as a predictor for postoperative complications in patients with solid cancers: a meta-analysis.Frontiers in oncology · 2024Pooled it
- Geriatric Nutritional Risk Index and Survival of Patients With Colorectal Cancer: A Meta-Analysis.Frontiers in oncology · 2022Pooled it
- The Geriatric Nutritional Risk Index Predicts Short- and Long-Term Outcomes in the Oldest-Old With Colorectal Cancer: A Multi-Institutional Analysis of 225 Nonagenarians.Annals of gastroenterological surgery · 2026Article
- The Geriatric Nutritional Risk Index and its association with all-cause mortality in cancer patients with sepsis: a dual-center retrospective cohort study.Frontiers in nutrition · 2026Article
- Association of TyG-BMI and malnutrition with reduced survival outcomes in patients with cancer: a prospective study.Frontiers in nutrition · 2026Article
- Impact of prognostic nutritional index and geriatric nutritional risk index on prognosis in elderly patients with early-stage prostate cancer.Frontiers in nutrition · 2026Article
- Impact of age on short-term outcomes and oncologic prognosis after radical surgery for colorectal cancer over 60.International journal of colorectal disease · 2025Article
- Predictive value of three nutritional indexes for disease activity in patients with inflammatory bowel disease.Annals of medicine · 2025Article
- Geriatric Nutritional Risk Index and In-Hospital Mortality and Costs in Older Inpatients With and Without Cancer: A Retrospective Observational Study.Journal of clinical nursing · 2025Observational
- Prognostic value of systemic inflammation-modified Patient-Generated Subjective Global Assessment in advanced cancers: A large-scale retrospective cohort study.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2025Article
- Clarifying Geriatric Nutrition Risk Index Classification in Critically Ill Patients with Severe Coronavirus Disease 2019.Tuberculosis and respiratory diseases · 2025Article
- Association between the geriatric nutritional risk index and all-cause mortality in older critically ill patients with community-acquired pneumonia.Nutrition journal · 2025Article
- Association of Systemic Inflammatory Response Index and Prognostic Nutritional Index Scores with Sarcopenia in Patients with Metastatic Gastric Cancer.Medicina (Kaunas, Lithuania) · 2025Article
- Article
- Predictive value of preoperative L3-SMI, AGR, and PNI for overall survival in patients undergoing radical gastrectomy for gastric cancer.Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences · 2025Article
- The prealbumin-CD19BMC cancer · 2025Article
- Association between geriatric nutritional risk index and clinical outcome of elderly aneurysmal subarachnoid hemorrhage patients: insights from a large cohort study.Neurosurgical review · 2025Observational
- Clinical analysis of the correlation between nutritional risk screening and prognosis of patients with chronic obstructive pulmonary disease.Pakistan journal of medical sciences · 2025Article
- Geriatric Nutritional Risk Index (GNRI) and Survival in Pancreatic Cancer: A Retrospective Study.Nutrients · 2025Article
9 more citing papers are in PubMed but not listed here.
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Authors and funding
17 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundSystemic inflammation and cachexia are associated with adverse clinical outcomes in elderly patients with cancer. The Geriatric Nutritional Risk Index (GNRI) is a simple and useful tool to assess these conditions, but its predictive ability for elderly patients with cancer cachexia (EPCC) is unknown.
methodsThis multicentre cohort study included 746 EPCC with an average age of 72.00 ± 5.24 years, of whom 489 (65.5%) were male. The patients were divided into two groups (high GNRI group ≥91.959 vs. low GNRI group <91.959) according to the optimal cut-off value of the ROC curve. The calibration curves were performed to analyse the prognostic, predictive ability of GNRI. Comprehensive survival analyses were utilized to explore the relationship between GNRI and the overall survival (OS) of EPCC. Interaction analysis was used to investigate the comprehensive effects of low GNRI and subgroup parameters on the OS of EPCC.
resultsIn this study, a total of 2560 patients were diagnosed with cancer cachexia, including 746 cases of EPCC. During the 3.6 year median follow-up, we observed 403 deaths. The overall mortality rate for EPCC at 12 months was 34.3% (95% CI: 62.3% to 69.2%), and resulting in rate of 278 events per 1000 patient-years. The GNRI score of EPCC was significantly lower than those of young patients with cancer cachexia (P < 0.001). The 1, 3, and 5 year calibration curves showed that the GNRI score had good survival prediction in the OS of EPCC. The GNRI could predict the OS of EPCC, whether as a continuous variable or a categorical variable. Particularly, we also found that low GNRI score (<91.959) of EPCC had a worse prognosis than those with a high GNRI score (≥91.959, P = 0.001, HR = 1.728, 95% CI: 1.244-2.401). Consistent results were observed in the tumour subgroups of gastric cancer and colorectal cancer. Notably, similar results were observed in the sensitivity analysis. In the subgroup analysis, the low GNRI has a combined effect with age (<70 years) on poor OS of EPCC. The results of the prognostic risk model found that the lower the GNRI score, the greater the prognostic risk score, and the greater the risk of death in EPCC.
conclusionsFor the first time, this study found that the GNRI score can serve as an independent prognostic factor for the OS of EPCC.
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