Evidence map›Paper›PMID 34585602›Full record

ArticleEnvironmental health perspectives2021

Examining the Developmental Trajectory of an

Steen K T Ooi, Hui Jiang, Yanyuan Kang, Patrick Allard

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Environmental health perspectives, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed.

  1. Article
  2. In vitro models of the male reproductive system: applications for developmental and reproductive toxicology.Toxicological sciences : an official journal of the Society of Toxicology · 2025
    Review
  3. Article
  4. Review
  5. Article
  6. Article
  7. Article
  8. Early Gonadal Development and Sex Determination in Mammal.International journal of molecular sciences · 2022
    Review
  9. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

4 authors.

Steen K T OoiUCLA Institute for Society & Genetics, University of California, Los Angeles, Los Angeles, California, USA.
Hui JiangUCLA Institute for Society & Genetics, University of California, Los Angeles, Los Angeles, California, USA.
Yanyuan KangUCLA Institute for Society & Genetics, University of California, Los Angeles, Los Angeles, California, USA.
Patrick AllardUCLA Institute for Society & Genetics, University of California, Los Angeles, Los Angeles, California, USA.ORCID 0000-0001-7765-1547

Funding

Mechanisms of memory of environmental exposure: determining the role of histone modifications in regulating transgenerational behavior effects caused by environmental chemical exposure.R01ES027487 · NIEHS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI ALLARD, PATRICK · 2017 to 2021
$1.8M
NIEHS NIH HHS R01 ES027487
6 · The paper itself

Abstract

backgroundAnimal-based studies indicate that bisphenol A (BPA) exposure is detrimental to reproductive health, but its impact on the earliest stages of germ cell development remains poorly defined.

objectivesUsing a murine

methodsWe used an established method of

resultsExposure of EpiLCs to BPA resulted in higher numbers of cells that were associated with a higher proportion of cells in S-phase as well as a lower proportion undergoing apoptosis; this difference occurred in a concentration-dependent manner. Exposure also resulted in a greater fraction of EpiLCs showing signs of DNA damage. Remarkably, EpiLC exposure did not negatively affect PGC specification and resulted in a concentration-dependent effect on PGCLC proliferation in XX but not XY cells. PGCLC transcriptome analysis revealed an aberrant program with significant deregulation of X-linked genes and retrotransposon expression. Differential gene expression analysis also revealed the deregulation of genes associated with lipid metabolism as well as deregulated expression of genes associated with later stages of gametogenesis.

conclusionsTo the best of our knowledge our findings represent the first characterization of the consequences of early BPA exposure on a model of mammalian PGC development, highlighting altered cell behavior, altered underlying pathways, and altered molecular processes. https://doi.org/10.1289/EHP8196.

Indexed as

Gene Expression ProfilingGerm CellsAnimalsBenzhydryl CompoundsBisphenol A CompoundsCell DifferentiationMicePhenolsBenzhydryl Compoundsbisphenol ABisphenol A CompoundsPhenols

Identifiers

PMID34585602
PMCPMC8480152

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.